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Journals / Türk Oftalmoloji Dergisi / 2003 / Cilt: 33 - Sayı: 1

The effect of topical antiglaucomatous treatment on conjunctival cell structure

Topikal antiglokomatöz tedavinin konjonktiva hücre yapısına etkisi

İhsan ÇAÇA
Nihal KILINÇ
Söker Sevin ÇAKMAK
Kubilay BİLEK
Kaan ÜNLÜ
Pages
22–27
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Decreased goblet cell counts and increased fibroblast cell numbers in both patient groups were detected compared to control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To detect the effect of topical antiglaucomatous drugs on conjunctiva cell profile in cases with primary open angle glaucoma.
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Key Findings & Data:Material and Method: Conjunctival biopsy was taken from 22 open angle glaucoma pati-ents using (beta-blocker + pilocarpin and from 15 control cases with similar ages.
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Conclusion & Impact:Decreased goblet cell counts and increased fibroblast cell numbers in both patient groups were detected compared to control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To detect the effect of topical antiglaucomatous drugs on conjunctiva cell profile in cases with primary open angle glaucoma. Material and Method: Conjunctival biopsy was taken from 22 open angle glaucoma pati-ents using (beta-blocker + pilocarpin and from 15 control cases with similar ages. Results: Patients taking antiglaucomatous treatment divided in to 2 groups according to treatment duration (group All cases treated over 1 year and group B 11 cases treated less thanl year). Decreased goblet cell counts and increased fibroblast cell numbers in both patient groups were detected compared to control group (p

Özet

Amaç: Primer açık açılı glokom (PAAG) tanısı ile takip edilen ve topikal antiglokomatöz ilaç kullanan olgularda topikal antiglokomatöz ilaçların konjonktiva hücre profiline etkisini araştırmak. Gereç ve Yöntem: Topikal (beta-bloker + Pilokarpin kullanan 22 PAAG'lu hastadan ve aynı yaş grubundaki 15 kontrol olgusundan alınan konjonktiva biyopsileri ışık mikroskobunda değerlendirildi. Antiglokomatöz tedavi alan olgular, bir yıldan fazla ilaç kullananlar (A grubu 11 olgu) ve bir yıldan az ilaç kullananlar (B grubu 11 olgu) olmak üzere iki gruba ayrıldı ve kontrol grubu (C grubu 15 olgu) ile karşılaştırıldı. Bulgular: Işık mikroskopisi ile konjonktiva epiteli ve substansia propria hücreleri kantitatif olarak incelendi. Goblet hücre sayısı, A grubunda daha az olmak üzere ilaç kullanan her iki grupta da kontrol grubuna göre istatistiksel olarak anlamlı derecede düşük saptandı (p

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Cite This Article

ÇAÇA, İ., KILINÇ, N., ÇAKMAK, S. S., BİLEK, K., ÜNLÜ, K. (2022). The effect of topical antiglaucomatous treatment on conjunctival cell structure. Türk Oftalmoloji Dergisi, Cilt: 33 - Sayı: 1, 22–27. https://ajindex.com/articles/638963

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References (16)

  1. Brandt JD, Wittpenn JR, Katz J, Steinmann WN, Speath GL: Conjunctival impression cytology in patients with glaucoma using long-term topical medication. Am J Ophthalmol. 1991;112:297-301
  2. Broadway DC, Grierson I, O'Brien C, Hitchings RA: Adverse effect of topical antiglaucoma medication. I.The conjunctival cell profile. Arch Ophthalmol. 1994; 112:1437-45
  3. Laibovitz R, Strahlman ER, Barber BL, Strahmaier KM: Comparison of quality of life and patient preference of dorzolamide and pilocarpine as adjunctive therapy to timolol in the treatment of glaucoma. J Glaucoma. 1995;4:306-13
  4. Scherwood MB, Grierson I, Millar L, Hitchings RA: Longterm morphologic effects of antiglaucoma drugs on the conjunctiva and Tenon's capsule in glaucomatous patients. Ophthalmology. 1989;96:327-35
  5. Baudouin C: Side effect of antiglaucomatous drugs on the ocular surface. Curr Opin Ophthalmol. 1996;7:80-86
  6. Broadway DC, Grierson I, O'Brien C, Hitchings RA: Adverse effect of topical antiglaucoma medication. II.The outcome of filtration surgery. Arch Ophthalmol. 1994; 112:1446-54
  7. Broadway D, Grierson I, Hitchings RA: Adverse effect of topical antiglaucomatous medications on the conjunctiva. Br J Ophthalmol. 1993;77:590-96
  8. Skuta GL, Parrish RK: ILWound healing in glaucoma filtering surgery. Ophthalmol. 1987;32:149-170
  9. Gerstenberger A, Marquardt R: Die Becherzelldichte unter pilocarpine influss. Fortschr Ophthalmol.1986;83:46- 50
  10. Steuhl KP, Knorr M, Frohn A, Thiel H-J: Überden Einfluss antiglaukomatöser Augentropfen auf die Zelldifferenzierung der konjunktiva. Fortschr Ophthalmol. 1991;88:865-69
  11. Smith DL, Skuta GL, Kincaid MC, Rabbani R, Cruess DF, Kao SF: The effects of glaucoma medications on Tenon's capsule and conjuctiva in the rabbit. Ophthalmic Surg. 1991;22:336-40
  12. Tseng SCG, Hirst LW, Maumence AE, Kenyon KR, Sun TT, Green WR: Possible mechanisms for the loss of goblet cells in musin-deficient disorders. Ophthalmology. 1984;91:545-52
  13. Williams DE, Nguyen KD, Shapourifar-Tehrani S, Kitada S, Lee DA: Effects of timolol, betaxolol and levobunolol on human Tenon's fibroblasts in tissue culture, invest Ophthalmol Vis Sci. 1992:2233-41
  14. Takahashi N: Cytotoxic effects of antiglaucoma agents on cultured human conjunctival cells. Acta Soc Ophthalmol Jpn. 1981; 85:1046-52
  15. Takahashi N: Cytotoxity of presevatives on cultured human conjunctival cells. Acta Soc Ophthalmol Jpn. 1980;84:l 171-76
  16. Young TC, Higginbotham EJ, Zou X, Farber M