Journals / Türk Oftalmoloji Dergisi / 2006 / Cilt: 36 - Sayı: 5

Comparison of efficiency of single dose intravitreal triamcinolone for various ocular diseases causing macular edema

Tek doz intravitreal triamsinolon enjeksiyonunun maküla ödemine neden olan hastalıklardaki etkinliğinin karşılaştırılması

Pages
422–429
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Increased intraocular pressure from steroids was observed mostly in eyes with vascular occlusion.

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Objective & Hypothesis:Purpose : To evaluate the effectiveness of intravitreal triamcinolone acetonide (IVTA) with retinal vascular and inflammatory choroidal diseases causing macular edema.Methods : Twenty eyes of 16 cases with macular edema from branch retinal vein occlusion (n=4). central retinal vein occlusion (n=2). diabetes mellitus (n=9). posterior uveitis (n=2) were evaluated after single dose of IVTA.
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Key Findings & Data:All cases (mean age. 54 years) were evaluated before and at 1. 2. 4 and 6 months after treatment by visual acuity. biomicroscobic examination. intraocular pressure. indirect ophthalmoscope. color fundus photography.Results : All cases followed-up for 6 months period.
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Conclusion & Impact:Increased intraocular pressure from steroids was observed mostly in eyes with vascular occlusion.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose : To evaluate the effectiveness of intravitreal triamcinolone acetonide (IVTA) with retinal vascular and inflammatory choroidal diseases causing macular edema.Methods : Twenty eyes of 16 cases with macular edema from branch retinal vein occlusion (n=4). central retinal vein occlusion (n=2). diabetes mellitus (n=9). posterior uveitis (n=2) were evaluated after single dose of IVTA. All cases (mean age. 54 years) were evaluated before and at 1. 2. 4 and 6 months after treatment by visual acuity. biomicroscobic examination. intraocular pressure. indirect ophthalmoscope. color fundus photography.Results : All cases followed-up for 6 months period. Final visual acuity (logMAR) (1.0 ± 0.5. mean ± SD) was significantly different than that of the initial examination (P=0.001). At least 2 Snellen lines improvement in visual acuity was observed in 3 of 3 eyes with posterior uveitis (100%). in 1 of 2 eyes with central retinal vein occlusion (50%). in 2 of 4 eyes with branch retinal vein occlusion (50%). in only 1 of 13 eyes with diffuse diabetic macular edema (8%). Increased IOP secondary to steroids was found in 66% of eyes with central retinal vein occlusion. in 38% of eyes with diffuse diabetic macular edema.Conclusion : At 6 months. IVTA improved visual acuity in eyes with macular edema from retinal vein occlusion and posterior uveitis significantly more than that of diffuse diabetic macular edema. Increased intraocular pressure from steroids was observed mostly in eyes with vascular occlusion.

Özet

Amaç: İntravitreal triamsinolon asetonid (IVTA) enjeksiyonunun maküla ödemine yol açan retina vasküler ve inflamatuar koroid hastalıklarındaki etkinliğinin araştırılması. Gereç ve Yöntem: Tek doz (0.1 cc. 4 mg) İVTA enjeksiyonu yapılan retina ven dal tıkanıklığı (n=4). santral retina ven tıkanıklığı (n=2). diyabet (n=9) ve arka üveite (Behçet hastalığı. n=2) bağlı maküla ödemi bulunan 16 hastanın (5 erkek. 12 kadın) 22 gözü çalışmaya dahil edildi. Olgular (ortalama yaş. 54 yıl). tedavi öncesi ve tedaviden 1. 2. 4 ve 6 ay sonra görme keskinliği. biyomikroskobik muayene. göziçi basınç ölçümü. indirek oftalmoskopi ve renkli fundus resimleriyle değerlendirildi. Bulgular: Olgular 6 ay takip edildi. Son takipteki görmeler (logMAR) (1.0 ± 0.5. ortalama ± SD) tedavi öncesine göre (1.4 ± 0.4) anlamlı olarak farklıydı (P=0.001). En az iki Snellen sırası görme artışı ise. arka üveitli üç gözün üçünde (%100). santral retina ven tıkanıklığı olan iki gözün birinde (%50). retina ven dal tıkanıklığı bulunan dört gözün ikisinde (%50) ve yaygın diyabetik maküla ödemi bulunan 13 gözün sadece birinde (%8) saptandı. Steroide bağlı göziçi basınç artışı. retina ven tıkanıklıklarında %66. yaygın diyabetik maküla ödeminde %38 oranında gözlendi. Sonuç: Altı aylık takipte İVTA. retina ven tıkanıklıklarına veya arka üveite bağlı maküla ödeminde görmeyi yaygın diyabetik maküla ödemine göre belirgin olarak arttırdı. Steroide bağlı göziçi basınç artış oranı en fazla vasküler tıkanıklığı bulunan olgularda gözlendi.

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Cite This Article

ÇEKİÇ, O., YILDIZOĞLU, Ü., BARDAK, Y. (2022). Comparison of efficiency of single dose intravitreal triamcinolone for various ocular diseases causing macular edema. Türk Oftalmoloji Dergisi, Cilt: 36 - Sayı: 5, 422–429. https://ajindex.com/articles/638741

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References (15)

  1. Clarkson JG: Central retinal vein occlusion. In retina Schachat AP ed. St Louis. Mosby. 2001; 1368
  2. Çekiç O, Chang S, Tseng J, et al: İntravitreal triamcinolone injection for treatment of macular edema secondary to branch retinal vein occlusion. Retina 2005;25:851-855
  3. Early treatment diabetic retinopathy study research group. Photocoagulation for diabetic macular edema: early treatment diabetic retinopathy study. Report number 1. Arch Ophthalmol 1985;103:1796-1806
  4. Lee CM, Oik RJ: Modified grid laser photocoagulation for diffuse diabetic macular edema. Ophthalmology 1991;98:1594-1602
  5. The Central Vein Occlusion Study Group. Evaluation of grid pattern photocoagulation for macular edema in cent¬ral vein occlusion: The Central Vein occlusion Group M Report. Ophthalmology 1995;102: 1425-1433
  6. The Central Vein Occlusion Study Group. Natural history and clinical management of central retinal vein occlusion. Arch Ophthalmol 1997; 115:486-491
  7. Kramer M, Ehrlich R, Snir M, et al: intravitreal injections of triamcinolone acetonide for severe vitritis in patients with incomplete Behfet's disease. Am J Ophthalmol 2004;138:666-667
  8. Martidis A, Düker JS, Greenberg PB, et al: intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology 2002;109:920-927
  9. Young S, Larkin G, Branley M, et al: Safety and efficacy of intravitreal triamcinolone for cystoid macular oedema in uveitis. Clin Experiment Ophthalmol 2001;29:2-6
  10. Antcliff RJ, Spalton DJ, Stanford MR, et al: intravitreal triamcinolone for uveitic cystoid macular edema: an optical tomographic coherence study. Ophthalmology 2001;108:765-772
  11. Ip M, Kumar KS: intravitreal triamcinolone acetonide as treatment for macular edema from central retinal vein occlusion. Arch Ophthalmol 2002;120:1217-1219
  12. Jonas JB, Kreissig I, Kampetter B, Degenring RF: Intravitreal triamcinolone acetonide for the treatment of intraocular edematous and neovascular diseases. Ophthalmologe 2003;101:113-120
  13. Vinores SA, Sen H, Campochiaro PA: An adenosine agonist and prostaglandin El cause breakdown of blood-retinal barrier by opening tight junctions between vascular endothelial cells. Invest Ophthalmol Vis Sci 1992; 33: 1870-1878
  14. Ozaki H, Hayashi H, Vinores SA, et al: Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates. Exp Eye Res 1997;64: 505-517
  15. Klein ML, Finkelstein D: Macula