Journals / Türk Oftalmoloji Dergisi / 2008 / Cilt: 38 - Sayı: 3

Correlation of serum acute phase reactants and lipid levels with retinal vascular complications of type 2 diabetes

Tip 2 diyabetin retinal vasküler komplikasyonları ile serum akut faz reaktanları ve lipid düzeyleri arasındaki ilişki

Pages
230–235
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Plasma total cholesterol and triglyceride levels were higher in study groups than the control group (p=0.02; p

📌 3 Key Takeaways

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Objective & Hypothesis:To investigate the serum acute phase reactants like fibrinogen and C-reactive protein (CRP) and serum lipid profile in association with the development of retinal vascular complications in patients with type 2 diabetes.
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Key Findings & Data:METHODS: Patients with type 2 diabetes without retinopathy (NoRP) (n=35), with nonproliferative retinopathy (NPDR) (n=35) and proliferative diabetic retinopathy (PDR) (n=35) were included in the study.
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Conclusion & Impact:Plasma total cholesterol and triglyceride levels were higher in study groups than the control group (p=0.02; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

To investigate the serum acute phase reactants like fibrinogen and C-reactive protein (CRP) and serum lipid profile in association with the development of retinal vascular complications in patients with type 2 diabetes. METHODS: Patients with type 2 diabetes without retinopathy (NoRP) (n=35), with nonproliferative retinopathy (NPDR) (n=35) and proliferative diabetic retinopathy (PDR) (n=35) were included in the study. Age and sex matched healthy persons (n=35) accepted as control group. Serum fibrinogen, CRP, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, and triglyceride levels were determined in all participants. Data obtaining from groups were compared each other.RESULTS: There was no significant difference of age and sex among groups (p>0.05). Plasma fibrinogen levels in study groups were found significantly higher than the control group (p=0.001). Plasma CRP levels in PDR group were significantly lower than the other groups (p=0.04). NPDR, NoRP and control groups were not significantly different by means of CRP levels (p=0.84). HDL and LDL concentrations were not found different among groups (p=0.16; p=0.09). Plasma total cholesterol and triglyceride levels were higher in study groups than the control group (p=0.02; p

Özet

Tip 2 diyabeti olan hastalarda gelişen retinal vasküler komplikasyonlar ile serum akut faz reaktanlarından olan fibrinojen ve C-reaktif protein (CRP) ile lipid profili arasındaki ilişkinin incelenmesi. YÖNTEM: Tip 2 diyabetli olan ancak retinopatisi olmayan (NoRP) (n=35), nonproliferatif retinopatisi (NPDR) olan (n=35) ve proliferatif diyabetik retinopatisi (PDR) olan (n=35) hastalar çalışma kapsamına alındı. Benzer yaş ve cinsiyetteki sağlıklı bireyler kontrol grubu (n=35) olarak alındı. Hastaların serum fibrinojen, C-reaktif protein, yüksek yoğunluklu lipoprotein (HDL), düşük yoğunluklu lipoprotein (LDL), total kolesterol ve trigliserit düzeyleri tespit edildi. Elde edilen veriler gruplar arasında karşılaştırıldı.BULGULAR: Gruplar arasında yaş ve cinsiyet olarak anlamlı bir fark saptanmadı (p>0,05). Çalışma gruplarında plazma fibrinojen düzeyi kontrol grubuna göre anlamlı ölçüde yüksek bulundu (p=0,001). Plazma CRP düzeyi PDR grubunda diğer gruplara göre anlamlı oranda düşük bulundu (p=0,04). NPDR, NoRP ve kontrol gruplarında CRP düzeyleri arasında anlamlı bir fark saptanmadı (p=0,84). HDL ve LDL konsantrasyonu açısından gruplar arasında anlamlı fark saptanmadı (p=0,16; p=0,09). Plazma total kolesterol ve trigliserit düzeyi çalışma gruplarında kontrol grubundan anlamlı olarak yüksek bulundu (p=0,02; p

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Cite This Article

DURMUŞ, M., YAĞCI, R., ERDURMUŞ, M., OFLU, Y., DEMİR, N., ÖRNEK, F., ÜNLÜ, N. (2022). Correlation of serum acute phase reactants and lipid levels with retinal vascular complications of type 2 diabetes. Türk Oftalmoloji Dergisi, Cilt: 38 - Sayı: 3, 230–235. https://ajindex.com/articles/638615

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