Journals / Türk Oftalmoloji Dergisi / 2008 / Cilt: 38 - Sayı: 4

Evaluation of ocular blood flow by color doppler ultrasonography after intravitreal triamcinolone acetonide injection

İntravitreal triamsinolon asetonid enjeksiyonu sonrası oküler kan akımının renkli doppler ultrasonografi ile değerlendirilmesi

Pages
336–341
Publication Date
2022-11-05
DOI
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CONCLUSION: Variations in ocular blood flow after IVTA injection, especially in early periods, may occur, but these changes return to normal at 1st month.

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Objective & Hypothesis:PURPOSE: To evaluate changes in ocular blood flow by color doppler ultrasonography(CDU) after intravitreal triamcinolone acetonide(IVTA) injection.
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Key Findings & Data:IVTA injection was performed for diabetic macular edema(n=9), choroidal neovascular membrane(n=5), and edema due to retinal vein occlusion(n=3).
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Conclusion & Impact:CONCLUSION: Variations in ocular blood flow after IVTA injection, especially in early periods, may occur, but these changes return to normal at 1st month.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

PURPOSE: To evaluate changes in ocular blood flow by color doppler ultrasonography(CDU) after intravitreal triamcinolone acetonide(IVTA) injection. MATERIAL-METHODS: Seventeen patients who underwent IVTA injection were included in this study. IVTA injection was performed for diabetic macular edema(n=9), choroidal neovascular membrane(n=5), and edema due to retinal vein occlusion(n=3). Ocular blood flows of all patients were evaluated by CDU before IVTA injection, 1 week, and 1 month after injection. Contralateral eyes of patients were accepted as control group. Peak systolic velocity(PSV), end diastolic velocity(EDV), and resistivity index(RI) were measured from ophthalmic artery(OA), central retinal artery(CRA), and posterior ciliary artery(PCA) of all patients. RESULTS: Mean ages of patients were 64.8±8.7 (50-79) years. Mean ocular blood flow values before injection were not statistically different than control eyes (p=0.486). PSV measured from OA at 1st week (40.5±12.4cm/s) had increased compared to that before injection (35.8±12.4cm/s), but was not statistically significant (p=0.435). Mean RI measured from OA at 1st week (0.77±0.06) had increased compared to that before injection (0.73±0.09), and difference was statistically significant (p=0.032). Mean PSV of SRA at 1st week (9.2±3.4cm/s) had decreased compared to pre-treatment values (10.9±5.6cm/s), but difference was not statistically significant (p=0.463). Change in RI values of SRA before (0.75±0.11), and 1 week after (0.76±0.07) treatment was not statistically significant (p=0.523). PSV measured over PSA at 1st week (11.4±4.4cm/s) had also decreased compared to pre-treatment values (14.1±5.4cm/s), but difference was not statistically significant (p=0.210). There was no statistically significant difference between pre-treatment (0.74±0.11), and 1st week (0.74±0.07) values of RI measured over PSA (p=0.943). None of the measurements at 1st month showed any statistically significant changes compared to pre-treatment and 1st week measurements. CONCLUSION: Variations in ocular blood flow after IVTA injection, especially in early periods, may occur, but these changes return to normal at 1st month.

Özet

AMAÇ: İntravitreal triamsinolon asetonid (İVTA) enjeksiyonu sonrası oküler kan akımındaki değişiklikleri renkli doppler ultrasonografi (RDU) ile değerlendirmek. Materyel ve METOD: Diyabetik maküla ödemi (n=9), koroid neovasküler membran (n=5) ve retinal ven tıkanıklığına bağlı maküla ödemi (n=3) nedeniyle İVTA enjeksiyonu yapılan toplam 17 hasta çalışma kapsamına alındı. Tüm hastaların İVTA enjeksiyonu öncesi, enjeksiyondan sonra 1. hafta ve 1. ayda RDU ile oküler kan akımları değerlendirildi. Hastaların enjeksiyon yapılmayan diğer gözleri kontrol grubu olarak alındı. RDU ile oftalmik arter (OA), santral retinal arter (SRA) ve posterior siliyer arterlerin (PSA) maksimum sistolik hız (MSH), diyastol sonu hız (DSH) ve rezistivite indeksleri (Rİ) ölçüldü. BULGULAR: Hastaların ortalama yaşları 64.8±8.7(50-79) yıl idi. Enjeksiyon öncesi ortalama (ort.) oküler kan akımı değerleri kontrol gözlerle karşılaştırıldığında aralarında anlamlı bir fark yoktu (p=0.486). Birinci hafta OA ort. MSH’ı (40.5±12.4cm/s) enjeksiyon öncesine göre (35.8±12.4cm/s) artmış olmasına rağmen fark istatistiksel olarak anlamlı değildi (p=0.435). Birinci hafta OA ort. Rİ (0.77±0.06) enjeksiyon öncesine göre (0.73±0.09) artmıştı, fark istatistiksel olarak anlamlı idi (p=0.032). SRA’in 1. hafta ort. MSH’ı (9.2±3.4cm/s) enjeksiyon öncesine (10.9±5.6cm/s) göre azalmıştı ancak fark istatistiksel olarak anlamlı bulunmadı (p=0.463). SRA’in Rİ’nin enjeksiyon öncesi (0.75±0.11) ve 1. haftadaki (0.76±0.07) değerleri arasında istatistiksel olarak anlamlı bir fark yoktu (p=0.523). PSA’in 1. hafta ort. MSH’ı (11.4±4.4cm/s) da enjeksiyon öncesine (14.1±5.4cm/s) göre azalmıştı ancak fark istatistiksel olarak anlamlı değildi (p=0.210). PSA’in ort. Rİ’nin enjeksiyon öncesi (0.74±0.11) ve 1. hafta (0.74±0.07) değerleri arasında istatistiksel olarak anlamlı bir fark yoktu (p=0.943). Birinci ayda yapılan ölçümlerden hiçbirinde enjeksiyon öncesi ve 1. hafta değerlerine göre farklılık gözlenmedi. SONUÇ: İVTA enjeksiyonu sonrası oküler kan akımında özellikle erken dönemde değişiklik olabileceği ancak 1. ayda bu değişikliklerin normale döndüğü sonucuna vardık.

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Cite This Article

TOKLU, Y., ŞİMŞEK, Ş., ALTINTAŞ, A. G. K., SİMAVLI, H., ANAYOL, M. A., AŞIK, E. (2022). Evaluation of ocular blood flow by color doppler ultrasonography after intravitreal triamcinolone acetonide injection. Türk Oftalmoloji Dergisi, Cilt: 38 - Sayı: 4, 336–341. https://ajindex.com/articles/638611

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