Journals / Türk Oftalmoloji Dergisi / 2008 / Cilt: 38 - Sayı: 2

A new diagnostic tool for the detection of choroidal neovascularization secondary to age-related macular degeneration: preferential hyperacuity perimetry

Yaşa bağlı makula dejenerasyonuna bağlı gelişen koroid neovaskülarizasyonu tanısında yeni bir yöntem: preferential hyperacuity perimetri

Pages
139–143
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

PHP seems to be mostly effective for identifying central macular dysfunction in CNV secondary to AMD.

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Objective & Hypothesis:PURPOSE: To evaluate the efficacy of a new diagnostic tool for the diagnosis of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) known as preferential hyperacuity perimetry (PHP) to detect and localize the lesion.
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Key Findings & Data:Central 14°x14° visual field were tested PHP (Foresee PHP, Notalvision).
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Conclusion & Impact:PHP seems to be mostly effective for identifying central macular dysfunction in CNV secondary to AMD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

PURPOSE: To evaluate the efficacy of a new diagnostic tool for the diagnosis of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) known as preferential hyperacuity perimetry (PHP) to detect and localize the lesion. MATERIALS-METHODS: Patients diagnosed to have CNV related to AMD were enrolled in the study. All participants were evaluated by fundus fluorescein angiography (FFA) after a detailed ophthalmic examination. Central 14°x14° visual field were tested PHP (Foresee PHP, Notalvision). Hyperacuity deviation map and hyperacuity defect maps were recorded by PHP. Patients having high false positive or false negative ratios were excluded. The correlation between the localization of CNV detected by FFA and the possible retinal localization determined by PHP was investigated. RESULTS: Twenty eyes of 15 patients with a mean age of 70.6±7.1 years and a mean visual acuity of 0.3±0.2 were recruited in the study. In 7 eyes classic, in 3 eyes predominantly classic, in 3 eyes minimally classic, in 5 eyes occult CNV were detected by FFA. Only in 2 eyes pigment epithelium detachment (PED) was found. The estimated retinal localization demonstrated in hyperacuity defect map by PHP was found to be correlated with CNV localization by FFA in 18 eyes.CONCLUSION: In the majority of cases estimated retinal localization detected by PHP was correlated to CNV localization by FFA. PHP seems to be mostly effective for identifying central macular dysfunction in CNV secondary to AMD.

Özet

AMAÇ: Yaşa bağlı makula dejenerasyonuna (YBMD) bağlı gelişen koroid neovaskülarizasyonu (KNV) tanısında yeni bir yöntem olan ‘preferential hyperacuity perimetri’nin (PHP) lezyonu saptamada ve lokalizasyonunu belirlemedeki etkinliğinin değerlendirilmesi. YÖNTEM: Klinik olarak YBMD’na bağlı KNV tanısı konulan hastalar çalışma kapsamına alındı. Olgular detaylı oftalmolojik muayene sonrasında fundus floresan anjiografi (FFA) ile değerlendirildi. Tüm olgularda santral 14°x14°’lik görme alanı PHP (Foresee PHP, Notalvision) ile incelendi. PHP ile hyperacuity deviasyon haritası ve hyperacuity defekt haritaları kaydedildi. Yanlış pozitif ve yanlış negatif yüzdeleri güvenilir olmayan olgular çalışma dışında bırakıldı. FFA’de saptanan KNV yerleşimi ile PHP’de belirlenen tahmini retina lokalizasyonu arasındaki korelasyon incelendi. BULGULAR: Ortalama yaşları 70.6±7.1 yıl ve ortalama görme keskinliği 0.3±0.2 olan toplam 15 hastanın 20 gözü çalışma kapsamına alındı. FFA ile olguların 7’sinde klasik, 3’ünde baskın klasik, 3’ünde minimal klasik, 5’inde gizli KNV saptanırken 2 gözde sadece pigment epitel dekolmanı (PED) bulundu. PHP’de hyperacuity defekt haritasında belirlenen tahmini retina lokalizasyonunun 18 gözde FFA’de saptanan KNV yerleşimi ile uyumlu olduğu bulundu. SONUÇ: PHP’de saptanan tahmini retina lokalizasyonları ile FFA’deki membran lokalizasyonlarının büyük oranda örtüştüğü izlenmiştir. PHP, YBMD’na bağlı KNV olgularında gelişen santral makula fonksiyon bozukluğunu çoğunlukla belirliyebilmektedir. Anahtar kelimeler: Yaşa bağlı makula dejenerasyonu, koroid neovaskülarizasyonu, preferential hyperacuity perimetri.

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Cite This Article

ÖNCEL, M., BAŞAR, D., YENEREL, M., DİNÇ, U. A., GÖRGÜN, E. (2022). A new diagnostic tool for the detection of choroidal neovascularization secondary to age-related macular degeneration: preferential hyperacuity perimetry. Türk Oftalmoloji Dergisi, Cilt: 38 - Sayı: 2, 139–143. https://ajindex.com/articles/638581

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References (13)

  1. Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study (AREDS): Design impli cations. AREDS report no
  2. Control Clin Trials 1999; 20(6):573-600
  3. Erdem Ü, Bayraktar MZ, Uysal Y. Yaşa bağlı makula de jenerasyonunda antioksidan tedavinin etkinliği-1. Retina Vitreus 2004; 12:26-29
  4. Ferris FLIII, Fine SL, Hyman L. Age-related macular de generation and blindness due to neovascular maculo pathy. Arch Ophthalmol 1984; 102:1640-1642
  5. Verteporfin Roundtable Participants. Guidelines for using verteporfin (Visudyne) in photodynamic therapy to treat choroidal neovascularization due to age-related macular degeneration and other causes: update. Retina 2005;25:119-134
  6. Gragoudas ES, Adamis Ap, Cunningham ET Jr, Feinsod M, Guyer DR. VEGF Inhibition study in ocular neovas cularization clinical trial group. Pegaptanib for neovascu lar age-related macular degeneration. New Eng J Med 2004;351:2805-2816
  7. Emerson MW, Lauer AK, Flaxel CJ, Wilson DJ, Francis PJ, Stout JT, Emerson GG, Schlesinger TK, Nolte SK, Klein ML. Intravitreal bevacizumab (Avastin) treatment of age-related macular degeneration. Retina 2007;27:439-444
  8. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY; MARINA Study Group. Rani bizumab for noevascular age-related macular degenerati on. N Eng J Med 2006 Oct 5;355(14): 1419-1431
  9. Submacular Surgery Trials (SST) Research Group. Sur gery for hemorrhagic choroidal neovascular lesions of age-related macular degeneration: ophthalmic findings. SST report no
  10. Ophthalmology 2004; 111:1993-2006
  11. Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group. Photodyna mic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two years results of 2 randomized clinical trials-TAP report 2. Arch Ophthalmol 2001;119:198-207
  12. Verteporfin in Photodynamic Therapy Study Group. Ver teporfin theraphy of subfoveal choroidal neovascularizati on in age-related macular degeneration: two-years results of a randomized clinical trial including lesions with oc cult but no classic neovascularization-Verteporfin in Pho todynamic Therapy report 2. Am J Ophthalmol 2001; 131:541-560
  13. Treatment of Age-Related Macular Degeneration wit Photodynamic Therapy Study Group, Verteporfin in Pho todynamic Therapy Study Group. Effect of lesion size, vi sual acuity, and lesion composition on visual acuity chan ge with and without verteporfin th