Journals / Türk Oftalmoloji Dergisi / 2010 / Cilt: 40 - Sayı: 6

Evaluation of the relationship between retinal nerve fiber layer and ganglion cell complex measured by optical coherence tomography in glaucomatous and normal cases

Glokomlu ve normal olgularda optik koherens tomografi ile retina sinir lifi tabakası ve ganglion hücre kompleksi ilişkisinin değerlendirilmesi

Pages
338–342
Publication Date
2022-11-05
DOI
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SSI of RNFL results were statistically significantly lower compared to SSI of GCC.Discussion: The measurement of GCC by OCT was found as remarkable as the measurement of RNFL in distinguishing glaucoma patients from the normal subjects.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To compare the optical coherence tomography (OCT) measurements of retinal nerve fiber layer (RNFL) and ganglion cells complex (GCC) thickness in primary open-angle glaucoma patients and normal patients.
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Key Findings & Data:Material and Method: 274 eyes of 137 subjects were enrolled in the study: 86 glaucoma patients and 51 normal subjects as a control group.
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Conclusion & Impact:SSI of RNFL results were statistically significantly lower compared to SSI of GCC.Discussion: The measurement of GCC by OCT was found as remarkable as the measurement of RNFL in distinguishing glaucoma patients from the normal subjects.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To compare the optical coherence tomography (OCT) measurements of retinal nerve fiber layer (RNFL) and ganglion cells complex (GCC) thickness in primary open-angle glaucoma patients and normal patients. Material and Method: 274 eyes of 137 subjects were enrolled in the study: 86 glaucoma patients and 51 normal subjects as a control group. RNFL and GCC were measured by OCT. The average values of GCC and RNFL for each eye, the superior and inferior half measurements and the signal strength indicator (SSI) results were recorded. Results were statistically evaluated by correlation among the glaucoma patients and comparison between the normal and glaucoma groups.Results: There was no significant difference between the groups for age and gender distributions. The mean RNFL and GCC measurements were 97.03±13.85 mm in glaucoma patients and 113.48±9.00 mm in normal subjects. Superior half measurements were 95.83±13.71 mm in glaucoma patients and 111.49±11.14 mm in normal subjects. Inferior half measurements were 98.44±15.63 mm in glaucoma patients and 115.50±9.25 mm in normal subjects. Both GCC and RNFL averages and superior and inferior measurements were found statistically significantly lower in glaucoma group. SSI results were also statistically significantly lower in the glaucoma group. SSI of RNFL results were statistically significantly lower compared to SSI of GCC.Discussion: The measurement of GCC by OCT was found as remarkable as the measurement of RNFL in distinguishing glaucoma patients from the normal subjects.

Özet

Amaç: Primer açık açılı glokomlu olgularda Optik Koherens Tomografi (OKT) ile ölçülen retina sinir lifi tabakası ve gangliyon hücre kompleksinin kalınlıklarının normal olgular ile karşılaştırılması. Gereç ve Yöntem: Çalışmaya 86’sı glokom 51’i normal olmak üzere 137 olgunun 274 gözü alındı. OKT ile retina sinir lifi tabakası (RSLT) ve gangliyon hücre kompleksi (GHK) ölçümleri yapıldı. Her göz için RSLT ve GHK ortalama değeri, alt ve üst yarıların ölçümü ile ölçüm sırasında alet tarafından verilen Sinyal gücü göstergesi (SGG) sonuçları kaydedildi. Sonuçlar, glokom hastalarının kendi aralarında korelasyonu ve kontrol grubu ile karşılaştırılması açısından istatistiksel olarak değerlendirildi. Sonuçlar: Her iki olgu grubu arasında yaş ve cinsiyet oranları açısından anlamlı fark bulunmadı. RSLT ve GHK ortalama değerleri glokomlu ve normal olgularda sırasıyla 97,03±13,85 mm, 113,48±9,00 mm; üst yarı ölçümleri yine sırasıyla 95,83±13,71 mm, 111,49±11,14 mm; alt yarı ölçümleri ise 98,44±15,63 mm, 115,50±9,25 Ìm olarak saptandı. Tüm değerler glokom olgularında kontrol grubuna göre istatiksel olarak anlamlı düzeyde düşük bulundu. SGG sonuçları değerlendirildiğinde ise yine glokom olgularında kontrol grubuna göre istatiksel olarak anlamlı düzeyde düşük bulundu. RSLT SGG sonuçları, GHK SGG sonuçları ile karşılaştırıldığında ise RSLT sonuçları GHK sonuçlarına göre istatiksel olarak anlamlı düzeyde düşük bulundu. Tartışma: Glokom hastalarının tanı ve izleminde RSLT kadar GHK ölçümünün de önemli olduğu dikkat çekici olmuştur.

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Cite This Article

BİLEN, H., HELVACIOĞLU, F., KORKMAZ, B., TUĞCU, B., AĞAÇHAN, A., TİĞİT, U. (2022). Evaluation of the relationship between retinal nerve fiber layer and ganglion cell complex measured by optical coherence tomography in glaucomatous and normal cases. Türk Oftalmoloji Dergisi, Cilt: 40 - Sayı: 6, 338–342. https://ajindex.com/articles/638438

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