SavedAdd your journal

Journals / Türk Oftalmoloji Dergisi / 2016 / Cilt: 46 - Sayı: 2

Ophthalmologic Findings in Children with Leukemia: A Single-Center Study

Lösemili Çocuklarda Oftalmolojik Bulgular: Tek Merkezli Bir Çalışma

Sezin AKÇA BAYAR
Namık ÖZBEK
Bülent ALİOĞLU
Zekai AVCI
Betül ORHAN
Barış MALBORA
Pages
62–67
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

To more clearly determine the effect of ophthalmologic manifestations on the prognosis of leukemia, larger scale and multi-center studies are needed

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Ophthalmologic disease in patients with acute leukemia occurs due to primary leukemic infiltration (involvement), or secondary to the disease and its treatment.
📊
Key Findings & Data:In recent years the life expectancy of acute leukemia patients has increased with the advent of modern therapies.
💡
Conclusion & Impact:To more clearly determine the effect of ophthalmologic manifestations on the prognosis of leukemia, larger scale and multi-center studies are needed
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: Ophthalmologic disease in patients with acute leukemia occurs due to primary leukemic infiltration (involvement), or secondary to the disease and its treatment. In recent years the life expectancy of acute leukemia patients has increased with the advent of modern therapies. The present study aimed to determine the incidence of ocular manifestations in children with acute leukemia.Materials and Methods: The study included 120 patients diagnosed with acute leukemia at Başkent University Hospital, Pediatric Hematology Department between 1995 and 2010. All the patients were examined by an ophthalmologist via direct and indirect ophthalmoscopy.Results: Among the patients, 83 (69.2%) were diagnosed with acute lymphoblastic leukemia, 35 (29.1%) with acute myeloblastic leukemia, and 2 (1.7%) with mixed-lineage leukemia. In all, 58 ophthalmic manifestations were noted in 41 patients (34.2%). In our patients, 12 ophthalmologic involvements were present at admission and 46 ocular findings occurred during follow-up. The incidence of these manifestations increased with age.Conclusion: Ophthalmologic manifestations were not correlated with gender, hematological parameters at disease onset, type of leukemia, or the frequency of relapse and survival. To more clearly determine the effect of ophthalmologic manifestations on the prognosis of leukemia, larger scale and multi-center studies are needed

Özet

Amaç: Akut lösemili hastalarda oftalmolojik bulgular primer lösemik infiltrasyon veya hastalık ve tedaviye sekonder olarak gelişebilir. Akut lösemili hastaların yaşam beklentisi, son yıllarda modern tedavi yöntemleri ile birlikte artmıştır. Bu çalışma akut lösemili çocuklarda oküler bulguların insidansını saptamayı amaçlamıştır.Gereç ve Yöntem: Bu çalışma, Başkent Üniversitesi Tıp Fakültesi Çocuk Hematoloji Bölümü'nde 1995-2010 yılları arasında akut lösemi tanısı alan 120 hastayı içermektedir. Tüm hastalar direkt ve indirekt oftalmoskopi ile bir göz hekimi tarafından muayene edilmiştir.Bulgular: Hastaların 83'ü (%69,2) akut lenfoblastik lösemi (ALL), 35'i (%29,1) akut miyeloblastik lösemi (AML), ikisi (%1,7) mikst lösemi idi. Tüm hastalar arasında 41 hastada (%34,2) 58 oftalmolojik bulgu tespit edildi. Oftalmolojik bulguların 12'si tanı esnasında, 46'sı ise tedavi ve takip sırasında saptandı. Bu bulguların oranı yaş ile birlikte artmaktaydı.Sonuç: Oftalmolojik bulgular, yaş, tanı esnasındaki hematolojik parametreler, lösemi tipi, relaps sıklığı veya sağkalım ile ilişkili bulunmadı. Lösemi prognozunda oftalmolojik bulguların etkinliğini daha iyi tanımlayabimek için çok merkezli ve daha büyük sayıda çalışmalara gereksinim vardır

🔖

Cite This Article

BAYAR, S. A., ÖZBEK, N., ALİOĞLU, B., AVCI, Z., ORHAN, B., MALBORA, B. (2022). Ophthalmologic Findings in Children with Leukemia: A Single-Center Study. Türk Oftalmoloji Dergisi, Cilt: 46 - Sayı: 2, 62–67. https://ajindex.com/articles/637950

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Poplack DG, Morgolin JF. Management of common cancers of childhood. In: Poplack DG, ed. Principles and practice of pediatric oncology I. Philadelphia; Saunders; 1997:409-504.
  2. Guyer DR, Schachat AP, Vitale S, Markowitz JA, Braine H, Burke PJ, Karp JE, Graham M. Leukemic retinopathy. Relationship between fundus lesions and hematologic parameters at diagnosis. Ophthalmology. 1989;96:860-864.
  3. Kincaid MC, Green WR. Ocular and orbital involvement in leukemia. Surv Opthalmol. 1983;27:211-232.
  4. Primack JD, Smith ME, Tychsen L. Retinal detachment in a child as the first sign of leukemic relapse: histopathology, MRI findings, treatment, and tumor- free follow up. J Pediatr Ophthalmol Strabismus. 1995;32:253-256.
  5. Ozyurek E, Alioglu B, Coskun M, Ozbek N. Successful use of short-course high-dose methylprednisolone in a child with acute myeloblastic leukemia (FAB M2) and myeloid tumor. Leuk Lymphoma. 2006;5:923-925.
  6. Ohkoski K, Tsiaras WG. Prognostic importance of ophthalmic manifestations in childhood leukaemia. Br J Ophthalmol. 1992;76:651-655. Redner A. Leukemias. In: Lanzkowsky P, ed. Manual of pediatric hematology and oncololgy. 5th ed. Elsevier, San Diego; USA; 2011;518-566.
  7. Russo V, Scott IU, Querques G, Stella A, Barone A, Delle Noci N. Orbital and ocular manifestations of acute childhood leukemia: clinical and statistical analysis of 180 patients. Eur J Ophthalmol. 2008;4:619-623.
  8. Rubnitz JE, Razzouk BI, Riberio RC. Acute myeloid leukemia. In: Pui CH, ed. Childhood leukemia. 2th ed.USA; 2006;19:499-540.
  9. Ridgway EW, Jaffe N, Walton DS. Leukemic ophthalmopathy in children. Cancer. 1976;38:1744-1749.
  10. Curto ML, Zingone A, Acquaviva A, Bagnulo S, Calculli L, Cristiani L, Dini G, Di Tullio MT, Guazzelli C, Jancovic M, et al. Leukemic infiltration of the eye: results of therapy in a retrospective multicentric study. Med Pediatr Oncol. 1989;17:134-139.
  11. Garrido Colino C, Mateos González M, Torres Valdivieso M, López Pérez J, Melero Moreno C, Vivanco Martínez J. Ocular infiltration in the anterior chamber in a female infant with acute non-lymphoblastic leukaemia. An Esp Pediatr. 2001;55:69-72.
  12. Reinhardt D, Pekrun A, Lakomek M, Zimmermann M, Ritter J, Creutzig U. Primary myelosarcomas are associated with a high rate of relapse, report on 34 children from the acute myeloid leukaemia-Berlin-Frankfurt-Münster studies. Br J Haematol. 2000;4:863-866.
  13. Sharma T, Grewal J, Gupta S, Murray PI. Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role. Eye (Lond). 200