Journals / Türk Oftalmoloji Dergisi / 2017 / Cilt: 47 - Sayı: 3

Assessment of Corneal Densitometry in Rheumatoid Arthritis Patients

Romatoid Artritli Hastalarda Kornea Dansitometre Değerlendirmesi

Pages
125–129
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Corneal densitometry as an objective measure of corneal clarity warrants further studies in order to ascertain its clinical relevance in RA patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To evaluate corneal densitometry and anterior segment parameters of rheumatoid arthritis (RA) patients and compare these results with those of age-matched healthy control subjects.
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Key Findings & Data:For densitometry analysis, the 12-mm diameter area of the cornea was subdivided into four concentric radial zones and anterior, central, and posterior layers based on corneal depth.
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Conclusion & Impact:Corneal densitometry as an objective measure of corneal clarity warrants further studies in order to ascertain its clinical relevance in RA patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To evaluate corneal densitometry and anterior segment parameters of rheumatoid arthritis (RA) patients and compare these results with those of age-matched healthy control subjects. Materials and Methods: Anterior segment parameters and corneal densitometry of patients with RA and healthy control subjects were assessed by Scheimpflug corneal topography. For densitometry analysis, the 12-mm diameter area of the cornea was subdivided into four concentric radial zones and anterior, central, and posterior layers based on corneal depth. Right eyes of subjects were used for statistical analysis. Results: Twenty-three consecutive patients with RA and 22 healthy control subjects were included in the study. There was no significant difference with regard to age (p=0.487) or gender (p=0.514). When anterior segment parameters of both groups were compared, no significant difference was found (p>0.05). Total corneal densitometry values were statistically higher in the RA group (p=0.030). In addition, when subdivisions of the cornea were evaluated, higher densitometry values were found in the RA group in 0-2 and 2-6 mm radial zones both in the anterior and total depth (p=0.001, p=0.003 for the 0-2 mm zone and p=0.002, p=0.009 for the 2-6 mm zone). Corneal densitometry measurement was not correlated with central corneal thickness or simulated keratometry value in RA patients or healthy control subjects. Conclusion: The corneal densitometry values were higher in RA patients when compared to healthy control subjects, even if they had clinically clear corneas. Corneal densitometry as an objective measure of corneal clarity warrants further studies in order to ascertain its clinical relevance in RA patients.

Özet

Amaç: Romatoid artritli (RA) hastaların kornea dansitometre ve ön segment parametrelerini incelemek ve bunları yaş uyumlu sağlıklıbireylerle karşılaştırmak amaçlanmıştır.Gereç ve Yöntem: RA’lı hastaların ve sağlıklı bireylerin ön segment parametreleri ve kornea dansitometreleri Scheimpflug korneatopografi ile değerlendirildi. Dansitometre değerlendirmesi için 12 mm’lik kornea alanı 4 halkasal zon ve derinlemesine ön, merkezi vearka olarak 3 bölgeye ayrıldı. Hastaların ve sağlıklı bireylerin sağ gözleri istatistiksel karşılaştırma için kullanıldı.Bulgular: Yirmi üç ardışık RA hastası ve 22 sağlıklı birey çalışmaya dahil edildi. İki grup arasında yaş (p=0,487) ve cinsiyet (p=0,514)bakımından istatistiksel olarak anlamlı fark yoktu. Ön segment parametreleri karşılaştırıldığında iki grup arasında istatistiksel olarakanlamlı fark tespit edilmedi (p>0,05). Total kornea dansitometresi RA grubunda sağlıklı gruba göre yüksek olarak tespit edildi(p=0,030). 0-2 mm ve 2-6 mm halkasal zonlarda hem ön hem de total kornea dansitometresinin RA grubunda yüksek olduğu saptandı(0-2 mm halkasal zonda ön p=0,001, total p=0,003; 2-6 mm halkasal zonda ön p=0,002, total p=0,009). Her iki grupta korneadansitometre değerlerinin merkezi kornea kalınlığı ve keratometri değeri ile korelasyonunun olmadığı tespit edildi.Sonuç: Klinik olarak saydam korneası olsa bile, RA’lı hastalarda kornea dansitometre değerlerinin sağlıklı bireylerden yüksek olduğunutespit ettik. Kornea saydamlığının objektif bir ölçütü olan kornea dansitometrenin RA’lı hastalarda klinik önemini tespit etmek içindaha fazla çalışmaya ihtiyaç vardır.

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Cite This Article

ŞEKEROĞLU, M. A., ŞİMŞEK, M., YILMAZBAŞ, P., ANAYOL, M. A., BOSTANCI, B., GÜNAYDIN, S. (2022). Assessment of Corneal Densitometry in Rheumatoid Arthritis Patients. Türk Oftalmoloji Dergisi, Cilt: 47 - Sayı: 3, 125–129. https://ajindex.com/articles/637877

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