SavedAdd your journal

Journals / Türk Oftalmoloji Dergisi / 2017 / Cilt: 47 - Sayı: 5

Correlation of Corneal Endothelial Cell Density with Corneal Tomographic Parameters in Eyes with Keratoconus

Banu BOZKURT
Bengü EKİNCİ KÖKTEKİR
Süleyman OKUDAN
Mevlüt YILMAZ
Ali MEŞEN
Ümit KAMIŞ
Pages
255–260
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Mean ECD values were 2628±262 cells/mm2, 2541.9±260.4 cells/mm2, and 2414.6±384.3 cells/mm2 in mild,moderate, and severe keratoconus, respectively (p450 µm, 400-450 µm, and

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: To examine changes in corneal endothelial cell density (ECD) in different stages of keratoconus and evaluate its correlationwith corneal tomographic parameters.Materials and Methods: Two hundred six patients with keratoconus were enrolled in the study.
📊
Key Findings & Data:Automatic endothelial analysis was donewith the non-contact endothelial microscope (20x probe) of Confoscan-4 (NIDEK, Japan).
💡
Conclusion & Impact:Mean ECD values were 2628±262 cells/mm2, 2541.9±260.4 cells/mm2, and 2414.6±384.3 cells/mm2 in mild,moderate, and severe keratoconus, respectively (p450 µm, 400-450 µm, and
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To examine changes in corneal endothelial cell density (ECD) in different stages of keratoconus and evaluate its correlationwith corneal tomographic parameters.Materials and Methods: Two hundred six patients with keratoconus were enrolled in the study. Corneal topography was performedby Sirius (CSO, Italy), which has a rotating Scheimpflug camera and a Placido disc topographer. Automatic endothelial analysis was donewith the non-contact endothelial microscope (20x probe) of Confoscan-4 (NIDEK, Japan). The eyes were classified into stages basedon steepest keratometric value as follows: mild 52 D and according to thinnest cornea thickness(TCT) as 450 µm. Tomographic and endothelial cell parameters were compared among the groups usingKruskal-Wallis test and the correlations between them were analyzed using Spearman correlation.Results: The study included 391 eyes of 100 male (24.29±7.7 years, range 11-47 years) and 106 female (26.26±7.5 years, range 13-45years) patients (p=0.07). Mean ECD values were 2628±262 cells/mm2, 2541.9±260.4 cells/mm2, and 2414.6±384.3 cells/mm2 in mild,moderate, and severe keratoconus, respectively (p450 µm, 400-450 µm, and

🔖

Cite This Article

BOZKURT, B., KÖKTEKİR, B. E., OKUDAN, S., YILMAZ, M., MEŞEN, A., KAMIŞ, Ü. (2022). Correlation of Corneal Endothelial Cell Density with Corneal Tomographic Parameters in Eyes with Keratoconus. Türk Oftalmoloji Dergisi, Cilt: 47 - Sayı: 5, 255–260. https://ajindex.com/articles/637865

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Edmonds CR, Wung SF, Husz MJ, Pemberton B. Corneal endothelial cell count in keratoconus patients after contact lens wear. Eye Contact Lens. 2004;30:54-58.
  2. Zadnik K, Barr JT, Gordon MO, Edrington TB. Biomicroscopic signs and disease severity in keratoconus. Collaborative longitudinal evaluation of keratoconus (CLEK) Study Group. Cornea. 1996;15:139-146.
  3. El-Agha MS, El Sayed YM, Harhara RM, Essam HM. Correlation of Corneal Endothelial Changes With Different Stages of Keratoconus. Cornea. 2014;33:707-711.
  4. Laing RA, Sandstrom MM, Berrospi AR, Leibowitz HM. The human corneal endothelium in keratoconus: a specular microscopic study. Arch Ophthalmol. 1979;97:1867-1869.
  5. Matsuda M, Suda T, Manabe R. Quantitative analysis of endothelial mosaic pattern changes in anterior keratoconus. Am J Ophthalmol. 1984;98:43-49.
  6. Hollingsworth JG, Efron N, Tullo AB. In vivo corneal confocal microscopy in keratoconus. Ophthalmic Physiol Opt. 2005;25:254-260.
  7. Ozgurhan EB, Kara N, Yildirim A, Bozkurt E, Uslu H, Demirok A. Evaluation of corneal microstructure in keratoconus: a confocal microscopy study. Am J Ophthalmol. 2013;156:885-893.
  8. Timucin OB, Karadag MF, Cinal A, Asker M, Asker S, Timucin D. Assessment of corneal endothelial cell density in patients with keratoconus not using contact lenses. Cont Lens Anterior Eye. 2013;36:80-85.
  9. Yeniad B, Yilmaz S, Bilgin LK. Evaluation of the microstructure of cornea by in vivo confocal microscopy in contact lens wearing and non-contact lens wearing keratoconus patients. Cont Lens Anterior Eye. 2010;33:167-170.
  10. Weed KH, MacEwen CJ, Cox A, McGhee CN. Quantitative analysis of corneal microstructure in keratoconus utilising in vivo confocal microscopy. Eye (Lond). 2007;21:614-623.
  11. Bitirgen G, Ozkagnici A, Bozkurt B, Malik RA. In vivo corneal confocal microscopic analysis in patients with keratoconus. Int J Ophthalmol. 2015;8:534-539.
  12. Niederer RL, Perumal D, Sherwin T, McGhee CN. Laser scanning in vivo confocal microscopy reveals reduced innervation and reduction in cell density in all layers of the keratoconic cornea. Invest Ophthalmol Vis Sci. 2008;49: 2964-2970.
  13. Mocan MC, Yilmaz PT, Irkec M, Orhan M. In vivo confocal microscopy for the evaluation of corneal microstructure in keratoconus. Curr Eye Res. 2008;33:933-939.
  14. Uçakhan O, Kanpolat A, Ylmaz N, Ozkan M. In vivo confocal microscopy findings in keratoconus. Eye Contact Lens. 2006;32:183-191.
  15. Sturbaum CW, Peiffer RL Jr. Pathology of corneal endothelium in keratoconus. Ophthalmologica. 1993;