Journals / Türk Oftalmoloji Dergisi / 2019 / Cilt: 49 - Sayı: 5

Intravitreal Dexamethasone Implant in the Treatment of Non-infectious Uveitis

Non-Enfeksiyöz Üveit Tedavisinde İntravitreal Deksametazon İmplant Uygulamaları

Pages
250–257
Publication Date
2022-11-06
DOI
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Mean BCVA was improved from 0.55 logMAR at baseline to 0.38, 0.32, and 0.35 after 1, 3, and 6 months, respectively (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To evaluate the long-term results of intravitreal dexamethasone implant (DEX) for noninfectious uveitis.
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Key Findings & Data:Materials and Methods: The study included 62 eyes of 44 patients treated with DEX implant due to noninfectious uveitis and followed up for at least a year.
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Conclusion & Impact:Mean BCVA was improved from 0.55 logMAR at baseline to 0.38, 0.32, and 0.35 after 1, 3, and 6 months, respectively (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To evaluate the long-term results of intravitreal dexamethasone implant (DEX) for noninfectious uveitis. Materials and Methods: The study included 62 eyes of 44 patients treated with DEX implant due to noninfectious uveitis and followed up for at least a year. Best-corrected visual acuity (BCVA), central foveal thickness, intraocular pressure (IOP), vitreous haze score, indications, immunomodulatory therapy and steroid usage before/after injection, number of injections, and adverse events were analyzed retrospectively. Results: Average follow-up was 20 months (range 12-64 months). The female/male ratio was 29/15. Mean age was 50 years (range 22-75 years). The most frequent uveitis etiologies were idiopathic (25 patients, 40.3%) and Behçet’s uveitis. (17 patients, 27.4%) The signedmost common indication for DEX injection was cystoid macular edema together with resistant vitreous haze (26 eyes, 41.9%). Twenty-two eyes (30%) received more than one DEX injection. Mean BCVA was improved from 0.55 logMAR at baseline to 0.38, 0.32, and 0.35 after 1, 3, and 6 months, respectively (p

Özet

Amaç: Enfeksiyöz olmayan üveit tanısı olan gözlerde intravitreal deksametazon-implant (DEX) uygulamalarının uzun dönemsonuçlarını değerlendirmektir.Gereç ve Yöntem: En az 1 yıl takibi olan erişkin grup 44 hastanın 62 gözü çalışmaya dahil edilmiştir. En iyi düzeltilmiş görmekeskinliği (EİDGK), santral foveal kalınlık (SFK), göz içi basıncı (GİB), vitreus bulanıklık skoru, enjeksiyon nedeni, enjeksiyon öncesi/sonrası immün-baskılayıcı ve steroid kullanımı, enjeksiyon sayısı ve komplikasyon sıklığı geriye dönük değerlendirilmiştir.Bulgular: Ortalama takip süresi 21±10 (12-64) ay idi. Kadın/erkek oranı 29/15 idi. Ortalama yaş 50±14,5 (22-75) idi. En sık üveitetiyolojileri idiyopatik üveit (25 olgu %40,3) ve Behçet hastalığı (17 olgu, %27,4) idi. Başlıca DEX enjeksiyonu sebepleri gözde kistoidmaküler ödem ve dirençli vitreus bulanıklığı birlikteliği (26 göz, %41,9) idi. Takip süresince 22 (%30) göze tekrarlayan enjeksiyonlar(19 göz iki enjeksiyon, 3 göz üç enjeksiyon) uygulandı. Enjeksiyon sonrası ortalama EİDGK 0,55 LogMAR’dan sırasıyla 1., 3. ve 6.ayda 0,38, 0,32 ve 0,35’e çıktı (p

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Cite This Article

ATALAY, H. T., HASANREİSOĞLU, M., ÖZDEMİR, H. B., ÖZDEK, Ş., GÜRELİK, G., ÖZKAN, K., YÜKSEL, M., AKTAŞ, Z. (2022). Intravitreal Dexamethasone Implant in the Treatment of Non-infectious Uveitis. Türk Oftalmoloji Dergisi, Cilt: 49 - Sayı: 5, 250–257. https://ajindex.com/articles/637726

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