Journals / Türk Oftalmoloji Dergisi / 2019 / Cilt: 49 - Sayı: 6

Tuberculosis: A Cunning Disease Presenting with EndopericarditisAssociated Bilateral Uveitis

Tüberküloz: Endoperikarditle İlişkili Bilateral Üveit ile Belirti Veren Sinsi Bir Hastalık

Pages
361–363
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Ocular tuberculosis can masquerade as other causes of intraocular inflammation, and a medical team consisting of an ophthalmologist and an infectious disease specialist might be needed for the diagnosis and management.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Mycobacterium tuberculosis can spread through the entire body but rarely involves the eye.
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Key Findings & Data:Finally, we chose isoniazid/ethambutol combination for 18 months, and also administered short-term systemic corticosteroid.
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Conclusion & Impact:Ocular tuberculosis can masquerade as other causes of intraocular inflammation, and a medical team consisting of an ophthalmologist and an infectious disease specialist might be needed for the diagnosis and management.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Mycobacterium tuberculosis can spread through the entire body but rarely involves the eye. We report a patient with endophthalmitis in one eye and simultaneous retinal vasculitis in the fellow eye. Systemic work-up suggested infective endopericarditis. Polymerase chain reaction analyses of the vitreous and pericardial fluid were positive for M. tuberculosis. We initiated a four-drug antituberculous treatment regimen (isoniazid, ethambutol, pyrazinamide, and rifampin). After two weeks, we discontinued all the medications due to drug-induced hepatitis. We restarted isoniazid and rifampin, but hepatitis recurred. Finally, we chose isoniazid/ethambutol combination for 18 months, and also administered short-term systemic corticosteroid. His vision improved considerably with no recurrence of hepatitis or tuberculosis for 3 years after completion of treatment. Ocular tuberculosis can masquerade as other causes of intraocular inflammation, and a medical team consisting of an ophthalmologist and an infectious disease specialist might be needed for the diagnosis and management.

Özet

Mycobacterium tuberculosis tüm vücuda yayılabilir, ancak nadiren gözü tutar. Bir gözde endoftalmi ve eş zamanlı olarak diğer gözderetina vasküliti görülen bir olguyu sunuyoruz. Hastanın sistemik değerlendirmesi enfektif endoperikardite işaret etmekteydi. Vitreus veperikardiyal sıvının polimeraz zincir reaksiyonu analizlerinde M. tuberculosis pozitif bulundu. Hastaya dört ilaçtan oluşan antitüberküloztedavi rejimi (izoniazid, etambutol, pirazinamid ve rifampin) başlandı. İki hafta sonra, ilaca bağlı hepatit nedeniyle tüm ilaçlar kesildi.İzoniazid ve rifampin tekrar başlandı, ancak hepatit nüks etti. Son olarak, 18 ay boyunca izoniazid/etambutol kombinasyonu seçildive tedaviye ek olarak kısa süreli sistemik kortikosteroid verildi. Tedavi tamamlandıktan sonra 3 yıl boyunca hastada hepatit veya TBnüksü görülmedi ve görme önemli ölçüde düzeldi. Oküler TB, intraoküler enflamasyona neden olan diğer hastalıkları anımsatarakmaskelenebilir ve tanı ve tedavi için bir göz hekim ile bir enfeksiyon hastalıkları uzmanından oluşan bir ekibe ihtiyaç duyulabilir.

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Cite This Article

YAGHOUBI, G. H., ABEDI, F., ZIAEE, M., NOROUZPOUR, A. (2022). Tuberculosis: A Cunning Disease Presenting with EndopericarditisAssociated Bilateral Uveitis. Türk Oftalmoloji Dergisi, Cilt: 49 - Sayı: 6, 361–363. https://ajindex.com/articles/637714

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