Journals / Türk Oftalmoloji Dergisi / 2020 / Cilt: 50 - Sayı: 4

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

Sağlıklı Çocuklarda Optik Disk ve Makülanın Optik Koherens Tomografi Anjiyografi ile Değerlendirilmesi

Pages
228–233
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Determination of normative values in children will be useful in detecting pathologic changes in tissue in patients with retinal diseases.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To perform the measurements of the optic disc and macula in healthy children using optical coherence tomography angiography (OCTA) in order to determine the normative data values and compare these by age, gender, spherical equivalent (SE), and axial length (AL).
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Key Findings & Data:Materials and Methods: A total of 146 eyes belonging to 146 healthy children (74 girls, 72 boys) aged 6 to 16 years were included in this prospective study.
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Conclusion & Impact:Determination of normative values in children will be useful in detecting pathologic changes in tissue in patients with retinal diseases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To perform the measurements of the optic disc and macula in healthy children using optical coherence tomography angiography (OCTA) in order to determine the normative data values and compare these by age, gender, spherical equivalent (SE), and axial length (AL). Materials and Methods: A total of 146 eyes belonging to 146 healthy children (74 girls, 72 boys) aged 6 to 16 years were included in this prospective study. Refraction and biometry measurements were performed. Retinal nerve fiber layer thickness (RNFLT), central macular volume, and central macular thickness (CMT) were measured by optical coherence tomography (OCT) after dilatation. Using the OCTA device, foveal avascular zone (FAZ) area, vascular density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula, and the VD of the radial peripapillary capillary plexus (RPCP) of the optic disc were recorded. Results: The mean age of the study group was 11.27±3 years, the mean AL was 23.39±1.18 mm and the mean SE was -1.31±1.61 diopters. The mean FAZ area was 0.3±0.09 mm2, the mean SCP-VD was 43.88±3.4%, the mean DCP-VD was 39.6±3.55%, and the mean RPCP-VD was 52.47±3.42%. When the relationship between the OCTA measurements and the SE and AL values were analyzed, there was no statistical significance (p>0.05). When age and OCTA measurements were compared, only DCP-VD values were found to significantly decrease with increasing age (p=0.015). There was no significant difference in OCTA measurements based on gender (p>0.05). Similarly, no statistical age-based differences were observed in RNFLT, CMV and CMT values (p>0.05). Conclusion: With its short procedure time and no dye requirement, OCTA can be safely used in the evaluation of the optic disc and macular perfusion in children. Determination of normative values in children will be useful in detecting pathologic changes in tissue in patients with retinal diseases.

Özet

Amaç: Sağlıklı çocuklarda optik koherens tomografi anjiyografi (OKTA) cihazı ile optik disk ve maküla ölçümlerinin yapılarak normatif data değerlerinin belirlenmesi ve bu değerlerin yaş, sferik ekivalan ve aksiyel uzunluk (AU) ile karşılaştırılması.Gereç ve Yöntem: Çalışmaya 6 ile 16 yaş arasında olan 146 sağlıklı çocuğun (74 kız, 72 erkek) 146 gözü dahil edildi. Katılımcıların refraksiyon ve biyometri ölçümleri yapıldı. Hastaların dilatasyon sonrası optik koherens tomografi (OKT) cihazı ile retina sinir lifi tabakası kalınlığı (RSLTK), santral makülar hacim (SMH), santral makülar kalınlık (SMK) ölçümleri yapıldı. OKTA cihazı ile foveal avasküler zon (FAZ), makülada yüzeysel ve derin tabaka kapiller pleksusta vasküler dansite (YKP-VD, DKP-VD) ölçümleri değerlendirildi. Optik diskte radiyal peripapiller kapiller pleksus vasküler dansite (RPKP-VD) ölçümleri kaydedildi.Bulgular: Yaş ortalaması 11,27±3 yıl olan çalışma grubunda AU ortalaması 23,39±1,18 mm ve sferik ekivalan değerleri ortalaması -1,31±1,61 diyoptri idi. FAZ ölçümü ortalaması 0,3±0,09 mm2 ve YKP-VD ortalaması %43,88±3,4 iken; DKP-VD ortalaması %39,6±3,55 idi. Optik diskte yapılan ölçümde RPKP-VD değerleri ortalaması %52,47±3,42 idi. OKTA ile yapılan ölçümler sferik ekivalan ve AU değerleri ile kıyaslandığında anlamlı fark tespit edilmedi (p>0,05). Yaş ile OKTA ölçümleri kıyaslandığında sadece derin retinal vasküler dansite değerinin yaş artışı ile anlamlı azaldığı saptandı (p=0,015). OKTA ölçümlerinde cinsiyet açısından anlamlı fark yoktu (p>0,05). Bunun yanında yaş ile RSLTK, SMH, SMK değerleri arasında istatistiksel fark saptanmadı (p>0,05).Sonuç: OKTA kısa çekim süresi, boya kullanımına ihtiyaç duyulmaması ile çocuklarda optik disk ve makülar perfüzyonun değerlendirilmesinde güvenle kullanılabilir. Çocuklarda normatif değerlerin belirlenmesi retinal hastalığı olan olgularda dokudaki patolojik değişiklikleri saptamak açısından yararlı olacaktır.

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Cite This Article

UÇAK, T., UĞURLU, A., İÇEL, E., YILMAZ, H., TAŞLI, N. G., KARAKURT, Y. (2022). Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography. Türk Oftalmoloji Dergisi, Cilt: 50 - Sayı: 4, 228–233. https://ajindex.com/articles/637651

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