Journals / Türk Oftalmoloji Dergisi / 2020 / Cilt: 50 - Sayı: 1

The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population

Beyaz Irkta Gangliyon Hücre Kompleksi Kalınlığının Total Retinal Kalınlığa Oranının Glokom Tanısındaki Yeri

Pages
26–30
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Unpaired t test was used to compare the measured values between the healthy subjects and the different patient groups.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To evaluate the diagnostic accuracy of the macular ganglion cell complex-to-total retinal thickness (G/T) ratio in a Caucasian population.
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Key Findings & Data:Materials and Methods: A total of 86 patients were enrolled in this cross-sectional study.
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Conclusion & Impact:Unpaired t test was used to compare the measured values between the healthy subjects and the different patient groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To evaluate the diagnostic accuracy of the macular ganglion cell complex-to-total retinal thickness (G/T) ratio in a Caucasian population. Materials and Methods: A total of 86 patients were enrolled in this cross-sectional study. Patients were divided into 4 groups: healthy; ocular hypertension; preperimetric glaucoma; and early glaucoma. Macular ganglion cell complex (mGCC) thickness, total retinal thickness, and retinal nerve fiber layer thickness (RNFLT) in one randomly selected eye of each patient were measured with measured with Heidelberg HD spectral domain optical coherence tomography (Heidelberg Engineering, Inc., Heidelberg, Germany). G/T ratio (%) was calculated as (mGCC thickness / total retinal thickness) ×100. The ability of each parameter to diagnose glaucoma was examined by area under the receiver operating characteristic curve (AUROC) analysis and sensitivity evaluation at a fixed level of specificity. Unpaired t test was used to compare the measured values between the healthy subjects and the different patient groups.

Özet

Amaç: Beyaz ırkta maküler gangliyon hücre kompleksinin total retinal kalınlığa oranının glokom için tanısal değerinin belirlenmesi.Gereç ve Yöntem: Bu kesitsel çalışmaya toplam 86 hasta dahil edilmiştir. Hastalar sağlam, oküler hipertansiyon, preperimetrik glokom ve erken glokom olmak üzere 4 gruba ayrılarak incelenmiştir. Her hastanın rastgele seçilen bir gözünde maküler gangliyon hücre kompleksi (GHK) kalınlığı, total retinal kalınlık ve retinal sinir lifi kalınlığı parametreleri Heidelberg HD spektral domain optikkoherens tomografi (Heidelberg Engineering, Inc., Heidelberg, Almanya) ile ölçülmüştür. Gangliyon hücre kompleksi/total retinal kalınlık (G/T) oranı belirtilen formül ile hesaplanmıştır: G/T oranı (%) = (maküler GHK kalınlığı/total retinal kalınlık)x100. Her bir parametrenin glokom tanısı koymadaki yeterliliği alıcı işlem karakteristikleri eğrisi altında kalan alan (AUROC) analizi ve sabit spesifitede sensitivite değerlendirilmesi ile belirlenmiştir. Sağlam olgular ve seçilmiş hasta gruplarının ölçülen değerleri eşlenmemiş t-test kullanılarak karşılaştırılmıştır.Bulgular: Dokuz sağlam olgu, 18 oküler hipertansiyon hastası, 28 preperimetrik glokom ve 31 erken glokom hastası incelenmiştir. Maküler gangliyon hücre kompleksi, total retinal kalınlık, retinal sinir lifi tabakası kalınlığı ve G/T oranının sağlıklı hastalar, oküler hipertansiyon hastaları, preperimetrik glokom hastaları ve erken glokom hastalarında sırayla gittikçe azaldığı görülmüştür ve gruplar arasındaki fark istatistiksel olarak anlamlıdır (p

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Cite This Article

ÇOLAK, M., ÖZTÜRK, C., AKMAN, A., AKSOY, M., SEZENÖZ, A. S., GÜNGÖR, S. G., CEZAİRLİOĞLU, Ş. (2022). The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population. Türk Oftalmoloji Dergisi, Cilt: 50 - Sayı: 1, 26–30. https://ajindex.com/articles/637638

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