Journals / Türk Oftalmoloji Dergisi / 2021 / Cilt: 51 - Sayı: 5

Experimental Laboratory Modeling of Choroidal Vasculature: A Study of the Dynamics of Intraoperative Choroidal Hemorrhage during Pars Plana Vitrectomy

Koroidin Vasküler Yapısının Laboratuvar Modellemesi: Pars Plana Vitrektomi Esnasında İntraoperatif Koroidal Hemoraji Dinamiklerini Değerlendiren bir Çalışma

Pages
294–300
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

All correlations were statistically significant (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Choroidal hemorrhages (CH) result from rupture of choroidal vessels leading to extravasation of blood into the suprachoroidal space.
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Key Findings & Data:Materials and Methods: We modeled the choroidal vasculature using a rubber tube 10 cm in length and 1 cm in diameter that was wrapped with conductive thread to enable the measurement of stress at the walls of the tube.
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Conclusion & Impact:All correlations were statistically significant (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Choroidal hemorrhages (CH) result from rupture of choroidal vessels leading to extravasation of blood into the suprachoroidal space. In this study, we aimed to understand the hemodynamics of CH by developing a purpose-built scale model of the choroidal vasculature and calculating stress levels in the model under different conditions. Materials and Methods: We modeled the choroidal vasculature using a rubber tube 10 cm in length and 1 cm in diameter that was wrapped with conductive thread to enable the measurement of stress at the walls of the tube. Stress levels across the tube were continuously measured under different systemic intravascular blood pressure levels (IVP), intraocular pressure (IOP) levels, and distortion. Results: Stress values across the choroidal vessel model correlated negatively with IOP and positively with IVP and distortion. All correlations were statistically significant (p

Özet

Amaç: Koroid kanamaları (KK), koroid damarlarının rüptürü ve kanın supra koroid boşluğuna ekstravazasyonu ile meydana gelir. Koroid damar sistemini daha iyi şekilde anlamak için, bu çalışmada amaca yönelik olarak ölçeklendirilmiş bir model kullanıldı. Bu model aracılığıyla, koroid damar sistemindeki stres düzeyleri farklı koşullar altında ölçüldü. Gereç ve Yöntem: Koroid damar yapısı modelinde, 1 cm genişliğinde ve 10 cm uzunluğunda lastik bir tüp kullanıldı. Modeldeki stres seviye ölçümü için ise özel iletken iplik kullanıldı. Modeldeki stres seviyeleri, farklı sistemik intravasküler kan basıncı seviyeleri (İVB), farklı göz içi basınç seviyeleri (GİB) ve farklı distorsiyon seviyeleri altında ölçüldü. Bulgular: Koroid damar modelindeki stres değerleri GİB ile negatif, İVB ve distorsiyon ile pozitif korelasyon gösterdi. Tüm korelasyonlar istatistiksel olarak anlamlı idi (p

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Cite This Article

ARAS, C., ŞENTÜRK, F., DOĞRAMACI, M., DİKKAYA, F. (2022). Experimental Laboratory Modeling of Choroidal Vasculature: A Study of the Dynamics of Intraoperative Choroidal Hemorrhage during Pars Plana Vitrectomy. Türk Oftalmoloji Dergisi, Cilt: 51 - Sayı: 5, 294–300. https://ajindex.com/articles/637637

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