SavedAdd your journal

Journals / Türk Oftalmoloji Dergisi / 2021 / Cilt: 51 - Sayı: 6

Effects of Myrtus communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats with a High Fat-Diet

Yüksek Yağlı Diyetle Beslenen Sıçanlarda Myrtus communis L. Ekstresi ve Aposinin’in Lens Oksidatif Hasarı ve Bor Seviyeleri Üzerindeki Etkileri

Feriha ERCAN
Ayşen YARAT
Rüya Kuru YAŞAR
Dilruba KURU
Göksel ŞENER
Ali ŞEN
Pages
344–350
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The HFD increased serum triglyceride (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals.
📊
Key Findings & Data:Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor.
💡
Conclusion & Impact:Results: The HFD increased serum triglyceride (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD). Materials and Methods: Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined. Results: The HFD increased serum triglyceride (p

Özet

Amaç: Diyetsel obezite, serbest radikal oluşumunu artırarak vücutta oksidan hasara ve lenste katarakt oluşumuna neden olmaktadır. Myrtus communis yaprak ekstraktlarının (Myr) antioksidan özelliklere sahip olduğu, Aposinin’in (Apo), etkili bir NADPH-oksidaz inhibitörü olduğu bilinmektedir. Doku bor seviyelerine ilişkin veriler oldukça eksiktir. Literatürde ilk kez gerçekleştirilen bu çalışmanın amacı, yüksek yağlı diyet (YYD) ile beslenen sıçanlarda Myr ve Apo tedavisinin bor seviyeleri ve oksidatif lens hasarı üzerine etkilerini araştırmaktır. Gereç ve Yöntem: Wistar albino erkek sıçanlar rastgele dört gruba ayrıldı: Kontrol Grubu; YYD Grubu; YYD + Myr Grubu ve YYD + Apo Grubu. Deney öncesinde ve sonrasında vücut ağırlığı ve kan lipid seviyeleri belirlendi. Sıçanlar dekapite edildikten sonra lensleri alındı ve homojenleştirildi. Lens homojenatlarında katalaz (KAT) ve süperoksit dismutaz (SOD) aktiviteleri, bor, malondialdehit (MDA) ve indirgenmiş glutatyon (GSH) seviyeleri belirlendi. Bulgular: YYD, sıçanların serum trigliserid (p

🔖

Cite This Article

ERCAN, F., YARAT, A., YAŞAR, R. K., KURU, D., ŞENER, G., ŞEN, A. (2022). Effects of Myrtus communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats with a High Fat-Diet. Türk Oftalmoloji Dergisi, Cilt: 51 - Sayı: 6, 344–350. https://ajindex.com/articles/637587

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res Clin Pract. 2013;7:e330-e341
  2. Nakazawa Y, Ishimori N, Oguchi J, Nagai N, Kimura M, Funakoshi-Tago M, Tamura M. Coffee brew intake can prevent the reduction of lens glutathione and ascorbic acid levels in HFD-fed animals. Exp Ther Med. 2019;17:1420-1425
  3. Umapathy A, Donaldson P, Lim J. Antioxidant delivery pathways in the anterior eye. Biomed Res Int. 2013;2013:207250
  4. Zhang J, Wang X, Vikash V, Ye Q, Wu D, Liu Y, Dong W. Ros and ROSmediated cellular signaling. Oxid Med Cell Longev. 2016;2016:4350965
  5. Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014:360438
  6. Yadav A, Kumari R, Yadav A, Mishra JP, Srivatva S, Prabha S. Antioxidants and its functions in human body-a review. Res Environ Life Sci. 2016;9:1328- 1331
  7. Zhang YJ, Gan RY, Li S, Zhou Y, Li AN, Xu DP, Li HB. Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules. 2015;20;21138-21156
  8. Lee MT, Lin WC, Yu B, Lee TT. Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals-a review. Asian-Australas J Anim Sci. 2017;30:299-308
  9. Karademir FK, Avunduk S. Antibacterial and antioxidant activity of Myrtus Communis L. growing wild in Marmaris. Gida. 2015;40:193-199
  10. Sen A, Yuksel M, Bulut G, Bitiş L, Ercan F, Ozyılmaz-Yay N, Akbulut O, Cobanoglu H, Ozkan S, Sener G. Therapeutic potential of Myrtus Communis subsp. communis extract against acetic acid-induced colonic inflammation in rats. J Food Biochem. 2017;41:e12297
  11. Hennia A, Miguel MG, Nemmiche S. Antioxidant activity of Myrtus Communis l. and Myrtus Nivellei batt. & trab. extracts: a brief review. Medicines. 2018;5:89
  12. Petrônio MS, Zeraik ML, Fonseca LM, Ximenes VF. Apocynin: chemical and biophysical properties of a NADPH oxidase inhibitor. Molecules. 2013;18:2821-2839
  13. Di PR, Mazzon E, Paterniti I, Impellizzeri D, Bramanti P, Cuzzocrea S. Apocynin, a plant-derived drug, might be useful in the treatment of myocardial ischemia reperfusion injury in rat hearts. Eur J Inflamm. 2011;9:157-168
  14. Kuru R, Yarat A. Boron and a current overview of its effects on health. Clin Exp Health Sci. 2017;7:107-114. (in Turkish)
  15. Kuru R, Mutlu EK, Cempel