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Journals / Türk Nöroşirürji Dergsi / 1999 / Cilt: 9 - Sayı: 2

CRH stimulation test and petrosal sinus sampling for the diagnosis of Cushing's disease: Case report

Cushing hastalığı tanısında kortikotropin salıcı hormon (CRH) stimülasyon testi ve petrozal venöz örnekleme: Olgu sunumu

Selçuk PALAOĞLU
Başar ATALAY
Olcay GEDİK
Bülent Okan YILDIZ
Pages
39–42
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This report presents a patient with Cushing's disease diagnosed by inferior petrosal sinus sampling and CRH stimulation, and treated surgically.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The clinical, biochemical, and radiographic features of ACTH-dependent hypercortisolism (Cushing's disease) are often indistinguishable from those of ectopic ACTH-dependent Cushing's syndrome.
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Key Findings & Data:Bilateral inferior petrosal sinus ACTH sampling with CRH stimulation is a useful test for differential diagnosis and preoperative location of pituitary microadenomas.
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Conclusion & Impact:This report presents a patient with Cushing's disease diagnosed by inferior petrosal sinus sampling and CRH stimulation, and treated surgically.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The clinical, biochemical, and radiographic features of ACTH-dependent hypercortisolism (Cushing's disease) are often indistinguishable from those of ectopic ACTH-dependent Cushing's syndrome. Bilateral inferior petrosal sinus ACTH sampling with CRH stimulation is a useful test for differential diagnosis and preoperative location of pituitary microadenomas. This report presents a patient with Cushing's disease diagnosed by inferior petrosal sinus sampling and CRH stimulation, and treated surgically.

Özet

ACTH'ya bağlı hiperkortizolizm (Cushing hastalığı) ile ektopik ACTH salınımına bağlı Cushing sendromunun klinik, biyokimyasal ve radyolojik bulguları genellikle birbirinden ayırt edilememektedir. CRH stimülasyon testi ile birlikte bilateral inferior petrozal sinüs örneklemesi, ayırıcı tanıda ve hipofiz mikroadenomlarının cerrahi öncesi lokalizasyonunda yararlı bir testtir. Bu olgu sunumunda, CRH stimulasyon testi beraberinde inferior petrozal sinüs örneklemesi yapılarak Cushing hastalığı tanısı koyulup, cerrahi olarak tedavi edilen bir hastadan ve konuyla ilgili literatürden bahsedildi.

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Cite This Article

PALAOĞLU, S., ATALAY, B., GEDİK, O., YILDIZ, B. O. (2022). CRH stimulation test and petrosal sinus sampling for the diagnosis of Cushing's disease: Case report. Türk Nöroşirürji Dergsi, Cilt: 9 - Sayı: 2, 39–42. https://ajindex.com/articles/637484

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