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Journals / Türk Nöroloji Dergisi / 2007 / Cilt: 13 - Sayı: 5

The evaluation of leukoaraiosis etiopathogenesis with MR-spectroscopy

Lökaryozis etyopatogenezinin MR-spektroskopi ile değerlendirilmesi

İlknur Aydın CANTÜRK
Fatma CANDAN
Tunahan AYAZ
Nüket YILDIZ
Nihal IŞIK
Pages
305–309
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

MI/Cr value of LA was significantly increased when compared with normal white matter (0.72±0.22 to 0.59±0.15; p

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Objective & Hypothesis:OBJECTIVE: Leukoaraiosis (LA), is a radiological finding with bilateral, either patchy or diffuse areas of the cerebral white matter.We aimed to determine proton MRS findings of LA and compare to those with chronic ischemic infarcts and control subjects, in order to understand the metabolic changes in LA.
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Key Findings & Data:METHODS: We compared 25 patients with LA, 10 patients with chronic ischemic infarct and 9 control subjects without LA.
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Conclusion & Impact:MI/Cr value of LA was significantly increased when compared with normal white matter (0.72±0.22 to 0.59±0.15; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Leukoaraiosis (LA), is a radiological finding with bilateral, either patchy or diffuse areas of the cerebral white matter.We aimed to determine proton MRS findings of LA and compare to those with chronic ischemic infarcts and control subjects, in order to understand the metabolic changes in LA. METHODS: We compared 25 patients with LA, 10 patients with chronic ischemic infarct and 9 control subjects without LA. Ratios for n-acetyl aspartate (NAA)/creatine (Cr) and myoinositol (MI)/Cr were obtained from leukoaraiotic area, chronic ischemic infarct and normal white matter. For the cognitive impairment Minimental Status Examination (MMSE) was applied to all individuals. RESULTS: Between LA and normal white matter, NAA/Cr values were shown no statistically significant difference. MI/Cr value of LA was significantly increased when compared with normal white matter (0.72±0.22 to 0.59±0.15; p

Özet

AMAÇ: Lökaryozis (LA), serebral beyaz maddede bilateral, gerek yama tarzında gerekse diffüz alanlar şeklinde izlenen radyolojik bir bulgudur. Bu çalışmada, lökaryozisdeki metabolik değişiklikleri anlamak için, lökaryozisin MR-spektroskopi bulgularını tespit ederek, bu bulguları, kronik iskemik enfarkt ve kontrol grubu ile karşılaştırmayı amaçladık. YÖNTEMLER: LA tespit edilen 25 hasta, kronik iskemik enfarktı bulunan 10 hasta ve LA bulunmayan 9 kontrol hastası kıyaslandı. Lökaryotik alandan, kronik iskemik enfarkt alanından ve normal görünümlü beyaz maddeden, N-asetilaspartat (NAA)/kreatin (Cr) ve myoinositol (MI)/Cr oranlarına bakıldı. Kognitif etkilenme açısından, bütün hastalara Minimental Status Examination (MMSE) testi uygulandı. BULGULAR: LA ve normal görünümlü beyaz madde NAA/Cr değerleri arasında istatistiksel açıdan anlamlı farklılık saptanmadı. Normal görünümlü beyaz maddeye kıyasla, LA MI/Cr değeri, anlamlı olarak yüksek saptandı (0.72±0.22; 0.59±0.15; p

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Cite This Article

CANTÜRK, İ. A., CANDAN, F., AYAZ, T., YILDIZ, N., IŞIK, N. (2022). The evaluation of leukoaraiosis etiopathogenesis with MR-spectroscopy. Türk Nöroloji Dergisi, Cilt: 13 - Sayı: 5, 305–309. https://ajindex.com/articles/637106

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References (16)

  1. Helenius J, Soinne L, Salonen O, Kaste M, Tatlisumak T: Leukoaraiosis, Ischemic Stroke and normal white matter on Diffusion-Weighted MRI. Stroke 2002;33:45
  2. Pantoni L, Garcia JH: The significance of cerebral white matter abnormalities 100 years after Binswanger’s report. Stroke 1995;(26):1293-1301
  3. Briley DP, Haroon S, Sergent SM, Thomas S: Does leukoaraiosis predict morbidity and mortality? Neurology 2000;54:90-94
  4. Pantoni L, Garcia JH: Pathogenesis of Leukoaraiosis. Stroke 1997;28:652-659
  5. Federico F, Simone IL, Lucivero V: Prognostic value of proton Magnetic Resonance Spectroscopy in Ischemic Stroke. Arch neurol 1998;55:489-494
  6. Jones DK, Lytgoe D, Horsfield MA: Characterization of white matter damage in Ischemic leukoaraiosis with Diffusion Tensor MRI. Stroke 1999;30:393-397
  7. O’Sullivan M, Morris RG, Huckstep B, Jones DK: Diffusion tensor MRI correlates with executive dysfunction in patients with ischemic leukoaraiosis. J Neurol NeurosurgPsychiatry. 2004 Mar;75(3):441-7
  8. Yamauchi H, Fukuyama H, Nagahama Y: Brain arteriolosclerosis and hemodynamic disturbance may induce lekoaraiosis. Neurology 1999;53:1833-1838
  9. Ramin SL, Tognola WA, Spotti AR: Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions. Sao Paulo Medical Journal 2003;121:1516-1521
  10. Castillo M, Smith JK, Kwock L: Correlation of myo-inositol levels and grading of cerebral astrocytomas. AJNR 2000;21:1645-1649
  11. Kurumtani T, Kudo T, Ikura Y,Takeda M: White matter changes in the gerbil brain under chronic cerebral hypoperfusion. Stroke 1998;29:1058-1062
  12. Lodder Jan, Bamford J, Kappelle J, Boiten J: What causes false clinical prediction of small deep infarcts? Stroke 1994;25:86-91
  13. Huang W, Alexander GE, Daly EM: High brain myo-inositol levels in the predementia phase of Alzheimer’s disease in adults with Down’s syndrome: A H MRS Study. Am J Psychiatry 1999;156:1879-1886
  14. Kantarci K, Jack CR, Xu YC: Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease: A 1H MRS study. Neurology 2000;55(2):210-7
  15. Waldman AD, Rai GS: The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer’s disease and vascular dementia: a proton magnetic resonance spectroscopy study. Neuroradiology 2003;45(8):507-12
  16. Jones RS, Waldman AD: 1H MRS evaluation of metabolism in Alzheimer’s disease and vascular dementia. Neurol Res 2004;26(5):488-95.