Risk factors for osteoporosis in renal transplant recipients

Objective & Hypothesis:OBJECTIVE: The aim of our study was to determine the frequency and risk factors of osteoporosis in patients who had undergone renal transplantation in our clinic and had a functional graft.MATERIAL and METHODS: This study included 92 patients who had undergone renal transplantation between 1997 and 2010 and whose bone mineral density was measured after transplantation.

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Key Findings & Data:RESULTS: Our study included 92 patients. 57 patients (62%) were male and 35 (38%) were female.

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Conclusion & Impact:These fi ndings show that bone mineral density is not a good parameter in the follow-up of bone disease after renal transplantation.

🔬Design:Research Article

📍Scope:2010 Verileri

⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: The aim of our study was to determine the frequency and risk factors of osteoporosis in patients who had undergone renal transplantation in our clinic and had a functional graft.MATERIAL and METHODS: This study included 92 patients who had undergone renal transplantation between 1997 and 2010 and whose bone mineral density was measured after transplantation. RESULTS: Our study included 92 patients. 57 patients (62%) were male and 35 (38%) were female. The mean age of the patients was 36 years (range: 19-62 years). According to the bone mineral density in the femur and/or lumbar vertebrae, 39 (42.4%) patients were normal, 39 (42.4%) had osteopenia and 14 (15.2%) had osteoporosis. There was no statistical relationship between the patients' age, gender, body mass index, history of parathyroidectomy, total steroid and immunosuppressive drug dose, creatininecalcium- phosphorus-alkaline phosphatase level at the time of the bone mineral density measurement and bone mineral density (p>0,05). CONCLUSION: We did not fi nd any relationship between the above risk factors and bone mineral density. These fi ndings show that bone mineral density is not a good parameter in the follow-up of bone disease after renal transplantation.

Özet

AMAÇ: Çalışmamızın amacı, böbrek nakli yaptığımız işlevsel grefti olan hastalarda osteoporoz sıklığını ve risk etmenlerini belirlemektir.GEREÇ ve YÖNTEMLER: 1997-2010 yılları arasında böbrek nakli yapılan, nakil sonrası kemik mineral yoğunluğu (KMY) ölçümü olan 92 hasta ile çalışmamız yapıldı. BULGULAR: 92 hastamızın 57'si (%62) erkek, 35'i (%38) kadın idi. Hastaların yaş ortalaması 36 yıldı (19-62 yıl). Femur ve/veya lomber vertebra KMY sonuçlarına göre; 39 (%42,4) hasta normal, 39 (%42,4) hastada osteopeni ve 14 (%15,2) hastada osteoporoz vardı. KMY sonuçları ile yaşın, cinsiyetin, vücut kitle indeksinin, paratiroidektomi durumunun, toplam steroid ve bağışıklığı baskılayıcı ilaç dozunun, KMY ölçümü sırasındaki serum kreatinin, kalsiyum, fosfor, alkalen fosfataz düzeylerinin arasında anlamlı ilişki yoktu (p>0,05). SONUÇ: Bizim çalışmamızda, risk faktörlerin hiçbirisi ile KMY arasında anlamlı bir ilişki saptanmadı. Bu bulgular; tek başına KMY ölçümünün böbrek naklinden sonra gelişmesi olası kemik hastalığını izlemede iyi bir gösterge olmadığını göstermektedir. Bu konuda pratik yeni yöntemlere gereksinim vardır.

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Cite This Article

KARATAŞ, A., YAKUPOĞLU, Y. K., ERDEM, E., KAYA, C., AKPOLAT, T., CENGİZ, K., ARIK, N., DİLEK, M., ÖZDEN, E. (2022). Risk factors for osteoporosis in renal transplant recipients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 21 - Sayı: 3, 267–272. https://ajindex.com/articles/636395

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