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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2017 / Cilt: 26 - Sayı: 1

Epigenetics and Nephrology

Epigenetik ve Nefroloji

Murat KARAMAN
Mahmut İlker YILMAZ
Hilmi Umut ÜNAL
Pages
11–17
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review summarizes recent research and the current status of epigenetic risk factors influencing AKI and CKD.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Acute kidney injury (AKI) is a risk factor for chronic kidney disease and death.
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Key Findings & Data:Despite progress made in understanding the cellular and molecular basis of kidney diseases pathogenesis there has been no improvement in the high mortality rate from these diseases.
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Conclusion & Impact:This review summarizes recent research and the current status of epigenetic risk factors influencing AKI and CKD.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Acute kidney injury (AKI) is a risk factor for chronic kidney disease and death. Chronic kidney disease (CKD) has become a serious public health problem because of its associated morbidity, mortality, and health care costs. Despite progress made in understanding the cellular and molecular basis of kidney diseases pathogenesis there has been no improvement in the high mortality rate from these diseases. Epigenetics is one of the most intensively studied fields of biology today and represents a new approach for understanding the pathophysiology of diseases. Epigenetics refers to functionally relevant modifications of the genome that do not involve a change in the nucleotide sequence. These modifications include acetylation, methylation, ubiquitylation, phosphorylation. These modifications serve to regulate gene expression without altering the underlying DNA sequence. Nutrient availability and other environmental factors cause changes in the epigenome. In chronic kidney disease (CKD), several features of uraemia, such as inflammation, may contribute to changes in epigenetic gene regulation. This review summarizes recent research and the current status of epigenetic risk factors influencing AKI and CKD.

Özet

Akut böbrek yetmezliği, kronik böbrek yetmezliği ve ölümle sonuçlanabilir. Kronik böbrek hastalığı da mortalite, morbitide ve sağlık masrafları açısından ciddi bir halk sağlığı problemidir. Bu hastalıklara yönelik hücresel ve moleküler birçok çalışma yapılsa da bu hastalıklardan dolayı yüksek mortalite oranlarında bir gelişme olmamıştır. DNA diziliminde bir değişiklik olmadan fonksiyonel modifikasyonları içeren epigenetik çalışmalar günümüzde biyolojinin ve genetiğin önemli bir kolu olup, böbrek hastalıklarının anlaşılmasında önemli bilgiler sunmuştur. Bu modifikasyonlar asetilasyon, metilasyon, fosforilasyon vb. şekilde olabilir. Kronik böbrek yetmezliğinde beslenme vb. çevresel birçok faktör de epigenom üzerinde değişikliğe neden olabilir. KBY hastalarında üreminin eşlik ettiği inflamasyon da bu değişikliklerde rol oynayabilir. Bu derlemede akut ve kronik böbrek yetmezliğinde epigenetik risk faktörleri, son çalışmalar ışığında özetlenmiştir.

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Cite This Article

KARAMAN, M., YILMAZ, M. İ., ÜNAL, H. U. (2022). Epigenetics and Nephrology. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 26 - Sayı: 1, 11–17. https://ajindex.com/articles/636090

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References (19)

  1. Reddy MA, Natarajan R: Recent developments in epigenetics of acute and chronic kidney diseases. Kidney Int 2015
  2. 261 2. Jain N, Reilly RF: Effects of dietary interventions on incidence and progression of CKD. Nat Rev Nephrol 2014
  3. 724 3. Leung KC, Tonelli M, James MT: Chronic kidney disease following acute kidney injury-risk and outcomes. Nat Rev Nephrol 2013
  4. 85 4. Kato M, Natarajan R: Diabetic nephropathy-emerging epigenetic mechanisms. Nat Rev Nephrol 2014
  5. 530 5. Villeneuve LM, Natarajan R: The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol 2010
  6. 25 6. McKnight AJ, McKay GJ, Maxwell A: Genetic and epigenetic risk factors for diabetic kidney disease. Adv Chronic Kidney Dis 2014
  7. 296 7. Kouzarides T: Chromatin modifications and their function. Cell 2007
  8. 705 8. Murrell A, Hurd PJ, Wood IC: Epigenetic mechanisms in development and disease. Biochem Soc Trans 2013
  9. 699 9. Meagher RB, Müssar KJ: The influence of DNA sequence on epigenome-induced pathologies. Epigenetics Chromatin 2012
  10. 11 10. Peschansky VJ, Wahlestedt C: Non-coding RNAs as direct and indirect modulators of epigenetic regulation. Epigenetics 2014
  11. 12 11. Mattick JS, Amaral PP, Dinger ME, Mercer TR, Mehler MF: RNA regulation of epigenetic processes. Bioessays 2009
  12. 59 12. ENCODE Project Consortium: An integrated encyclopedia of DNA elements in the human genome. Nature 2012
  13. 74 13. Mundade R, Ozer HG, Wei H, Prabhu L, Lu T: Role of ChIP-seq in the discovery of transcription factor binding sites, differential gene regulation mechanism, epigenetic marks and beyond. Cell Cycle 2014
  14. 2852 14. Metzker ML: Sequencing technologies--the next generation. Nat Rev Genet 2010
  15. 46 15.Jin M, Zhu S, Hu P, Liu D, Li Q, Li Z, Zhang X, Xie Y, Chen X: Genomic and epigenomic analyses of monozygotic twins discordant for congenital renal agenesis. Am J Kidney Dis 2014
  16. 122 16. O'Sullivan L, Combes AN, Moritz KM: Epigenetics and developmental programming of adult onset diseases. Pediatr Nephrol 2012
  17. 2182 17. Beckerman P, Ko YA, Susztak K: Epigenetics: A new way to look at kidney diseases. Nephrol Dial Transplant 2014
  18. 1827 18. Zhou VW, Goren A, Bernstein BE: Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 2011
  19. 18 19. Reddy MA, Tak Park J, Natarajan R: Epigenetic modifications in the pathogenesis of diabetic