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Journals / Türk Nefroloji Diyaliz ve Transplantasyon Dergisi / 2018 / Cilt: 27 - Sayı: 1

Relationship of Serum Asymmetric Dimethylarginine Levels with Inflammation and Cardiac Functions in Autosomal Dominant Polycystic Kidney Disease

Otozomal Dominant Polikistik Böbrek Hastalığında Serum Asimetrik Dimetilarginin Düzeyi ile İnflamasyon ve Kardiyak Fonksiyonlar Arasındaki İlişki

Barış ESER
Serdar KAHVECİOĞLU
Özlem YAYAR
Ahmet HÜNÜK
Hakan BAYOL
Şakir ALTUNER
İbrahim DOĞAN
Ünal KURTOĞLU
Pages
68–75
Publication Date
2022-11-05
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

In the patient group, left ventricular mass (LVM), left ventricular massindex (LVMI), left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) valueswere higher (p

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Objective & Hypothesis:OBJECTIVE: Most deaths in autosomal dominant polycystic kidney disease (ADPKD) are attributableto cardiovascular disease (CVD).
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Key Findings & Data:We aimed to search the relationship between serum ADMA,atherosclerosis, inflammation and cardiac functions in ADPKD.MATERIAL and METHODS: Fifty-seven ADPKD patients and 23 healthy control subjects wereenrolled.
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Conclusion & Impact:In the patient group, left ventricular mass (LVM), left ventricular massindex (LVMI), left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) valueswere higher (p
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Most deaths in autosomal dominant polycystic kidney disease (ADPKD) are attributableto cardiovascular disease (CVD). The relationship between serum asymmetric dimethylarginine(ADMA) and CVD has been investigated. We aimed to search the relationship between serum ADMA,atherosclerosis, inflammation and cardiac functions in ADPKD.MATERIAL and METHODS: Fifty-seven ADPKD patients and 23 healthy control subjects wereenrolled. Carotid artery intima-media thickness (CIMT) and echocardiographic measurementswere performed. ADMA, inflammatory markers, Neutrophil Count/Lymphocyte Count (NLR),echocardiographic findings and CIMT values were compared between the groups. Correlation analyseswere performed.RESULTS: ADMA levels were lower in patients compared to controls [10106 ng/L (2010-60000) vs.20161 ng/L (2902-60000), p=0.006]. CIMT was 0.67±0.03 mm in the patient group and 0.62±0.03 mmin the control group (p>0.05). In the patient group, left ventricular mass (LVM), left ventricular massindex (LVMI), left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) valueswere higher (p

Özet

AMAÇ: Otozomal Dominant Polikistik Böbrek Hastalığı (ODPBH)’nda en önemli mortalite nedeni kardiyovasküler (KV) hastalıklardır. Birçok çalışmada, serum asimetrik dimetilarjinin (ADMA) ile KV hastalıkların ilişkisi araştırılmıştır. Çalışmamızda erken evre ODPBH’da serum ADMA düzeyi ile inflamasyon ve atheroskleroz arasındaki ilişkiyi araştırmayı amaçladık. GEREÇ ve YÖNTEMLER: Çalışmaya ODPBH’lı 57 hasta ve 23 sağlıklı kontrol grubu alındı. Katılımcıların karotis arter intima-media kalınlığı (KIMK) ve ekokardiyografik (EKO) ölçümleri alındı. Gruplar arasında serum ADMA, inflamasyon belirteçleri, Nötrofil/Lenfosit oranı (NLO), EKO bulgular ve KİMK değerleri karşılaştırıldı. Korelasyon analizleri yapıldı. BULGULAR: Serum ADMA düzeyi hasta grubunda kontrol grubuna göre daha düşük saptandı [10106 ng/L (2010-60000) vs 20161 ng/L (2902-60000), p=0,006]. KIMK hasta grubunda 0,67±0,03mm, kontrol grubunda ise 0,62±0,03mm olarak saptandı (p>0,05). Hasta grubunda, sol ventrikül kitlesi (p

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Cite This Article

ESER, B., KAHVECİOĞLU, S., YAYAR, Ö., HÜNÜK, A., BAYOL, H., ALTUNER, Ş., DOĞAN, İ., KURTOĞLU, Ü. (2022). Relationship of Serum Asymmetric Dimethylarginine Levels with Inflammation and Cardiac Functions in Autosomal Dominant Polycystic Kidney Disease. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 27 - Sayı: 1, 68–75. https://ajindex.com/articles/636029

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