Journals / Türk Biyokimya Dergisi / 2019 / Cilt: 44 - Sayı: 2

The effect of Ramadan fasting on renal functions in patients with chronic kidney disease

Kronik Böbrek Yetmezlikli Hastalarda Oruç Açlığının Renal Fonksiyonlar Üzerine Etkisi

Pages
189–196
Publication Date
2022-11-04
DOI
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In univariate and multivariate logistic regression analysis, thepresence of diabetes mellitus and proteinuria were foundto be independent risk determinants of renal dysfunction.Conclusion: Patients with diabetes mellitus and prominent proteinuria may constitute critical patient groupsfor renal function deterioration during Ramadanfasting.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to investigate the effects of Ramadanfasting on renal functions in patients with stage 3 and 4chronic kidney disease.Materials and methods: The study was conducted inRamadan month which was between June and July.Patients were evaluated before Ramadan, the week immediately following the end of the Ramadan, and 3 and6 months after Ramadan.Results: Twenty-four fasting (mean age of 68 ± 13 years)and 55 non-fasting individuals (mean age of 69 ± 9 years)were included in this study.
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Key Findings & Data:There was no statistically significant difference for creatinine levels in the first weekafter Ramadan in both groups compared to levels beforeRamadan (p = 0.070, p = 0.470, respectively).
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Conclusion & Impact:In univariate and multivariate logistic regression analysis, thepresence of diabetes mellitus and proteinuria were foundto be independent risk determinants of renal dysfunction.Conclusion: Patients with diabetes mellitus and prominent proteinuria may constitute critical patient groupsfor renal function deterioration during Ramadanfasting.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to investigate the effects of Ramadanfasting on renal functions in patients with stage 3 and 4chronic kidney disease.Materials and methods: The study was conducted inRamadan month which was between June and July.Patients were evaluated before Ramadan, the week immediately following the end of the Ramadan, and 3 and6 months after Ramadan.Results: Twenty-four fasting (mean age of 68 ± 13 years)and 55 non-fasting individuals (mean age of 69 ± 9 years)were included in this study. There was no statistically significant difference for creatinine levels in the first weekafter Ramadan in both groups compared to levels beforeRamadan (p = 0.070, p = 0.470, respectively). The groupswere compared according to the criteria of deterioration inrenal function (reduction of 25% in GFR and 30% increasein serum creatinine levels). There were no statistically significant differences between the two groups according tothese two criteria (p = 0.452, p = 0.660, respectively). In univariate and multivariate logistic regression analysis, thepresence of diabetes mellitus and proteinuria were foundto be independent risk determinants of renal dysfunction.Conclusion: Patients with diabetes mellitus and prominent proteinuria may constitute critical patient groupsfor renal function deterioration during Ramadanfasting.

Özet

Amaç: Evre 3 ve 4 kronik böbrek hastalarında Ramazan orucunun renal fonksiyonlar üzerindeki etkisini araştırmayı amaçladık. Gereç ve yöntem: Çalışma haziran ve temmuz aylarına denk gelen Ramazan ayında yapıldı. Hastalar Ramazan öncesinde, Ramazan bitimini takip eden ilk haftada, 3. ay ve 6. ayda değerlendirildi. Bulgular: Çalışmaya oruç tutan 24 kişi (ortalama yaşları 68 ± 13 yıl) ve oruç tutmayan 55 kişi (ortalama yaşları 69 ± 9 yıl) dahil edildi. Her iki grupta da Ramazan öncesindeki ve Ramazan ayını takip eden ilk haftadaki serum kreatinin düzeyleri arasında anlamlı farklılık yoktu (sırasıyla p = 0.070, p = 0.470). Gruplar renal fonksiyonlarda bozulma kriterlerine (GFH’da % 25’in üzerinde azalma ve serum kreatinin düzeylerinde % 30’dan fazla artış) göre karşılaştırıldı. Bu iki kritere göre gruplar arasında istatistiksel olarak anlamlı farklılıklar yoktu (sırasıyla p = 0.452, p = 0.660). Univariate ve multivariate lojistik regresyon analizlerinde diabetes mellitus ve proteinürinin varlığı renal fonksiyon bozukluğunun bağımsız risk belirleyicileri olarak saptandı. Sonuç: Diabetes mellitusu ve belirgin proteinürisi olan hastalar Ramazan orucu açlığında böbrek fonksiyonlarında bozulma için riskli hasta gruplarını oluşturabilir.

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Cite This Article

ESER, B., KAYADİBİ, H., DOĞAN, İ. (2022). The effect of Ramadan fasting on renal functions in patients with chronic kidney disease. Türk Biyokimya Dergisi, Cilt: 44 - Sayı: 2, 189–196. https://ajindex.com/articles/620870

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