Journals / Türk Mikrobiyoloji Cemiyeti Dergisi / 2021 / Cilt: 51 - Sayı: 1

Change of the Frequency of Methicillin Resistance and Antibiogram Resistance Profile of Staphylococcus aureus within a Period of 15 Years

Staphylococcus aureus’un Onbeş Yılda Metisilin Direnç ve Antibiyogram Direnç Profilinin ve Görülme Sıklığının Değişimi

Pages
15–22
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: It was found that the rate of HA-MRSA decreased during the given period of 15 years.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this retrospective study was to evaluate the rate and antimicrobial resistance profile of community-acquired (CA) and hospital-acquired (HA) methicillin-resistant and sensitive Staphylococcus aureus (MRSA, MSSA) strains between 2004 and 2019.
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Key Findings & Data:Method: Within the scope of the research, the rate of MRSA and MSSA and the change in antimicrobial resistance profile over time were investigated using two research data of 210 Staphylococcus aureus strains isolated in 2004, and 401 in 2019.
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Conclusion & Impact:Conclusion: It was found that the rate of HA-MRSA decreased during the given period of 15 years.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this retrospective study was to evaluate the rate and antimicrobial resistance profile of community-acquired (CA) and hospital-acquired (HA) methicillin-resistant and sensitive Staphylococcus aureus (MRSA, MSSA) strains between 2004 and 2019. Method: Within the scope of the research, the rate of MRSA and MSSA and the change in antimicrobial resistance profile over time were investigated using two research data of 210 Staphylococcus aureus strains isolated in 2004, and 401 in 2019. Results: While any significant change was not seen in the rates of CA-MRSA (32.4%) and CA-MSSA (67.6%) in 2004, and of CA-MRSA (31.6%) and CA-MSSA (68.4%) in 2019, the prevalence of HA-MRSA decreased by 56.1% in 2004 and 30.7% in 2019 and of HA-MSSA increased by 43.9% in 2004 and 69.3% in 2019. No resistance to vancomycin and teikoplanin was observed in MRSA strains. Resistance of CA-MRSA against ciprofloxacin, levofloxacin, clindamycin and gentamicin decreased. In CA-MSSA an increase of penicillin resistance as well as a decrease in gentamicin resistance was observed. In resistance of HA-MRSA against ciprofloxacin, levofloxacin, erythromycin, clindamycin, gentamicin decreased. HA-Resistance of MSSA against fusidic acid increased and against ciprofloxacin and trimethoprim/sulfamethoxazole and erythromycin resistance decreased. Conclusion: It was found that the rate of HA-MRSA decreased during the given period of 15 years. Vancomycin or teicoplanin resistance was not observed in MRSA and MSSA. While against ciprofloxacin, levofloxacin, clindamycin, gentamicin decreased in both CA-MRSA and HA-MRSA. A closer follow-up of the prevalence and antimicrobial resistance profiles of these strains is of utmost importance for the successful control of the infections caused by MRSA and MSSA.

Özet

Amaç: Bu retrospektif çalışmanın amacı, 2004 ve 2019 yılları arasında toplum kaynaklı (TK) ve hastane kaynaklı (HK) metisiline dirençli ve duyarlı Staphylococcus aureus (MRSA, MSSA) suşlarının oran ve antimikrobiyal direnç profilinin değerlendirilmesidir. Yöntem: Araştırma kapsamında 2004 yılına ait 210 ve 2019 yılına ait 401 Staphyloococcus aureus suşunda iki ayrı zaman dilimi araştırma verileri kullanılarak, toplum kaynaklı ve hastane kaynaklı MRSA ve MSSA oranı ve antimikrobiyal direnç profilinin zaman içerisindeki değişimi incelendi. Bulgular: 2004 yılında toplum kaynaklı MRSA (%32.4) ve MSSA (%67.6) oranları ile 2019 yıllarındaki toplum kaynaklı MRSA (%31.6) ve MSSA (%68.4) oranları arasında anlamlı değişim gözlenmezken, HK-MRSA’nın 2004 yılında %56.1, 2019 yılı için %30.7 oranında azaldığı, 2004 yılında %43.9 olan HK-MSSA oranının, 2019 yılında %69.3 ile arttığı görüldü. MRSA’larda vankomisin ve teikoplanine karşı direnç gelişmediği gözlenmiştir. Toplum kaynaklı MRSA’ların siprofloksasin, levofloksasin, klindamisin ve gentamisin direnci azalmıştır. Toplum kaynaklı MSSA’ların penisilin direnci artarken, gentamisin direnci azalmıştır. Hastane kaynaklı MRSA’larda, siprofloksasin, levofloksasin, eritromisin, klindamisin ve gentamisin direnci düşüş gösterirken, MSSA’larda da fusidik asit direnci artmış, siprofloksasin, trimetoprim/sülfametoksazol ve eritromisin ve gentamisin direnci azalmıştır. Sonuç: Hastane kaynaklı MRSA oranlarının on beş yıllık zaman diliminde azaldığı saptanmıştır. Metisiline dirençli Staphylococcus aureus ve MSSA’da vankomisin ve teikoplanin direnci belirlenmemiştir. Toplum kaynaklı MRSA ve HK-MRSA’nın siprofloksasin, levofloksasin, klindamisin, gentamisin direnci azalmıştır. Hastanemizde enfeksiyon kontrol ve kısıtlı antibiyogram bildiriminin metisiline dirençli S. aureus ve MSSA’nın oranı ve antimikrobiyal direnç profilinin yakından izlenmesi bu enfeksiyonların kontrolünün başarısı açısından son derece önemlidir.

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Cite This Article

ŞANLI, K., ADALETİ, R., KÖMÜRCÜ, S. Z. M., KANSAK, N. (2022). Change of the Frequency of Methicillin Resistance and Antibiogram Resistance Profile of Staphylococcus aureus within a Period of 15 Years. Türk Mikrobiyoloji Cemiyeti Dergisi, Cilt: 51 - Sayı: 1, 15–22. https://ajindex.com/articles/635761

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