Journals / Türk Klinik Biyokimya Dergisi / 2014 / Cilt: 12 - Sayı: 1

Relationship Between Obesity Indices and C-Peptide in Healthy Adult Men

Sağlıklı Yetişkin Erkeklerde Obezite İndeksleri ile C-Peptid Arasındaki İlişki

Pages
15–20
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Whereas BAI was related to insülin resistance, it wasn t related to insülin secretion.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of the present study is to investigate the relation between new obesity indices waist circumference/height (WtHR), visceral adiposity index (VAI) and body adiposity index (BAI) and homeostasis model assessment of insülin resistance (HOMA-IR) index and pancreatic beta cell function in healthy adult men.
📊
Key Findings & Data:Materials and Methods: Non-smoker and non-drinker 51 healthy adult men whose HOMA-IR index were under the 2,5 included to this study.
💡
Conclusion & Impact:Whereas BAI was related to insülin resistance, it wasn t related to insülin secretion.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the present study is to investigate the relation between new obesity indices waist circumference/height (WtHR), visceral adiposity index (VAI) and body adiposity index (BAI) and homeostasis model assessment of insülin resistance (HOMA-IR) index and pancreatic beta cell function in healthy adult men. Materials and Methods: Non-smoker and non-drinker 51 healthy adult men whose HOMA-IR index were under the 2,5 included to this study. Fasting serum glucose, triglyceride, HDL, insulin and Cpeptide levels were measured and body mass index (BMI), WtHR, BAI and VAI were calculated. Insulin resistance was considered by HOMA-IR index; beta cell function and insulin secretion were considered by serum C-peptide level. Pearson s correlation test was performed to correlation analysis. Results: WtHR showed positive correlations with serum glucose, insülin and C-peptide levels (r values were; 0,411; 0,341 and 0,451 respectively). In addition BMI showed positive correlations with serum glucose, insülin and C-peptide levels too (r values were; 0,424; 0,396 and 0,473 respectively). VAI showed positive correlations with serum glucose and C-peptide levels (r values were; 0,725 and 0,354 respectively). BAI was not correlated with any biochemical parameters excepted HOMA-IR index. There were positive correlations between the HOMA-IR index and all of the obesity indices (r values were 0,434; 0,455; 0,526 and 0,572 respectively for BAI, VAI, WHtR and BMI). Conclusion: WtHR and BMI showed the strongest relationships with beta cell activity and insülin resistance. WHtR is the most reminder of BMI in this aspect. Although some metabolic parameters were used in calculation of VAI, it showed similar results to other indices. Whereas BAI was related to insülin resistance, it wasn t related to insülin secretion.

Özet

Amaç: Bu çalışmada, sağlıklı yetişkin erkeklerde yeni obezite indeksleri olan bel çevresinin boya oranı (BBO), visseral adiposite indeksi (VAİ) ve vücut adiposite indeksi (VtAİ) ile HOMA-IR (homeostasis model assesment of insulin resistance) indeksi ve pankreas beta hücre aktivitesi arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Bu çalışmaya, HOMA-IR indeksleri 2,5un altında bulunan, sigara ve alkol kullanmayan 51 sağlıklı yetişkin erkek dahil edildi. Açlık serum glukoz, trigliserid, HDL, insülin ve C-peptid düzeyleri ölçüldü ve vücut kitle indeksi (VKİ), BBO, VtAİ ve VAİ değerleri hesaplandı. İnsülin direnci HOMA-IR indeksi ile değerlendirildi; beta hücre fonksiyonu ve insülin sekresyonu ise serum C-peptid ve insülin düzeyleri ile değerlendirildi. Korelasyon analizleri için Pearson korelasyon testi uygulandı. Bulgular: BBO serum glukoz, insülin ve C-peptid düzeyleri ile pozitif korelasyon gösterdi (sırasıyla r değerleri; 0,411; 0,341 ve 0,451). Ayrıca VKİ de, serum glukoz, insülin ve C-peptid düzeyleri ile pozitif korelasyon gösterdi (sırasıyla r değerleri; 0,424; 0,396 ve 0,473). VAİ ise serum glukoz ve C-peptid düzeyleri ile pozitif korelasyon gösterdi (sırasıyla r değerleri; 0,725 ve 0,354). VtAİ, HOMA-IR haricinde hiçbir biyokimyasal parametre ile korele değildi. Bütün obezite indeksleri HOMA-IR indeksi ile pozitif korelasyon gösterdi (VtAİ, VAİ, BBO ve VKİ için sırasıyla r değerleri; 0,434; 0,455; 0,526 ve 0,572). Sonuç: Beta hücre aktivitesi ve insülin direnci ile en çok ilişkili olan indeksler VtAİ ve VKİdir. Bu yönden VKİye en çok benzeyen obezite indeksi BBOdur. Hesaplanırken bazı metabolik parametreler kullanılmasına rağmen, VAI diğer indekslerle benzer sonuçlar göstermiştir. VtAİ, insülin direnci ile ilişkili iken insulin sekresyonu ile ilişkili değildir.

🔖

Cite This Article

ÇIKIM, G., ŞAHİN, E., SARIÇİÇEK, E., KILINÇ, M., ÇELİK, A. (2022). Relationship Between Obesity Indices and C-Peptide in Healthy Adult Men. Türk Klinik Biyokimya Dergisi, Cilt: 12 - Sayı: 1, 15–20. https://ajindex.com/articles/634453

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Steiner DF, Cunningham D, Spigelman L, Aten B. Insulin Biosynthesis: Evidence for a Precursor. Science 1967; 157(3789):697–700
  2. Li Y, Meng L, Li Y, Sato Y. Associations of Serum CPeptide Level with Body Fat Distribution and Ever Stroke in Nondiabetic Subjects. J Stroke Cerebrovasc Dis 2013;23(3):e163-9 3. Bergstrom RW, Newell-Morris LL, Leonetti DL, Shuman WP, Wahl PW, Fujimoto WY. Association of elevated fasting C-peptide level and increased intraabdominal fat distribution with development of NIDDM in Japanese-American men. Diabetes 1990; 39(1):104-11
  3. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004; 363(9412):157–63
  4. Bozorgmanesh M, Hadaegh F, Khalili D, Azizi F. Prognostic Significance of the Complex "Visceral Adiposity Index" vs. Simple Anthropometric Measures. Cardiovasc Diabetol 2012;11(20):1-10
  5. Bergman RN, Stefanovski D, Buchanan TA, Sumner AE, Reynolds JC, Sebring NG, et al. A better index of body adiposity. Obesity (Silver Spring) 2011; 19(5): 1083-9
  6. Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, et al. Visceral adiposity index. a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care 2010; 33(4):920-2
  7. Du T, Sun X, Huo R, Yu X. Visceral adiposity index, hypertriglyceridemic waist and risk of diabetes: the China Health and Nutrition Survey 2009, International Journal of Obesity (Lond) 2013; doi: 10. 1038/ijo.2013.181
  8. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28(7): 412-9
  9. Schulze MB, Thorand B, Fritsche A, et al. Body adiposity index, body fat content and incidence of type 2 diabetes. Diabetologia 2012;55(6):1660-7
  10. Stepien M, Stepien A, Wlazel RN, Paradowski M, Rizzo M, Banach M, et al. Predictors of Insulin Resistance in Patients With Obesity: A Pilot Study. Angiology 2014; 65(1):22-30
  11. Vinknes KJ, Elshorbagy AK, Drevon CA, Gjesdal CG, Tell GS, Nygård O, et al. Evaluation of the Body Adiposity Index in a Caucasian Population: The Hordaland Health Study. Am J Epidemiol 2013; 177(6):586-92
  12. McCarthy HD. Body fat measurements in children as predictors for the metabolic syndrome: focus on waist circumference. Proc Nutr Soc 2006; 65(4):385– 92
  13. Meseri R, Ucku R, Un