Journals / Türk Kardiyoloji Derneği Arşivi / 2004 / Cilt: 32 - Sayı: 4

5-Florourasil tedavisine bağlı akut geçici diyastolik disfonksiyonu: Olgu bildirisi

Acute transient diastolic dysfunction induced by 5-Fluorouracil treatment: A case report

Pages
262–265
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

On the 15th day, diastolic dysfunction parameters returned to pre-treatment values.

📌 3 Key Takeaways

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Objective & Hypothesis:Cardiac toxicity of 5-fluorouracil has been described in several medical reportsincluding arrhythmias, angina pectoris, and myocardial infarction.
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Key Findings & Data:Themonitorization of the cardiac changes only by means of clinical signs, ECG andblood pressure leads to underestimation of 5-fluorouracil relatedcardiotoxicity.
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Conclusion & Impact:On the 15th day, diastolic dysfunction parameters returned to pre-treatment values.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Cardiac toxicity of 5-fluorouracil has been described in several medical reportsincluding arrhythmias, angina pectoris, and myocardial infarction. Themonitorization of the cardiac changes only by means of clinical signs, ECG andblood pressure leads to underestimation of 5-fluorouracil relatedcardiotoxicity. We report a cancer patient receiving 5-fluorouracil treatmentwith echocardiographic findings of reversible diastolic dysfunction. Serialechocardiographic evaluation of mitral inflow velocity patterns demonstratedabnormal relaxation pattern at baseline changing to restrictive type diastolicdysfunction at 48 hours after treatment with no symptoms or ECG changes. On the 15th day, diastolic dysfunction parameters returned to pre-treatment values.

Özet

5-Florourasilin kardiyak toksisitesine bağlı olarak gelişen aritmi, anginapektoris ve miyokard infarktüsü gibi birçok tıbbi sunum bildirilmiştir.5-Florourasil’e bağlı kardiyak toksisitenin takibinin, sadece klinik bulgular,kan basıncı ve EKG ile yapılması bu durumun olduğundan daha az saptanmasınaneden olabilmektedir. Biz 5-Florourasil tedavisi alan bir kanser hastasında,ekokardiyografik geçici diyastolik disfonksiyonun bulgularını bildirmekteyiz.Mitral akım hızı örneklerinin seri ekokardiyografik değerlendirilmesinde,başlangıçtaki anormal relaksasyon örneğinin tedaviden 48 saat sonra, semptomve EKG bulgusu olmaksızın, restiriktif tip diyastolik disfonksiyona değişmesigösterilmiştir. Onbeşinci günde diyastolik disfonksiyon parametreleri, tedaviöncesi değerlere dönmüştür.

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Cite This Article

ÖZTÜRK, B., CEYHAN, C., BARUTCA, S., MEYDAN, N., ONBAŞILI, A. O., TEKTEN, T. (2022). 5-Florourasil tedavisine bağlı akut geçici diyastolik disfonksiyonu: Olgu bildirisi. Türk Kardiyoloji Derneği Arşivi, Cilt: 32 - Sayı: 4, 262–265. https://ajindex.com/articles/633808

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References (1)

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