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Journals / Türk Kardiyoloji Derneği Arşivi / 2005 / Cilt: 33 - Sayı: 8

The relationship between endothelial nitric oxide synthase gene polymorphism (T-786 C) and coronary artery disease in a Turkish population

Endotelyal nitrik oksit sentetaz (eNOS) gen polimorfizminin (T-786 C) koroner arter hastalığı ile ilişkisi

Hüseyin AKSU
Sait TERZİ
Figen ÇİLOĞLU
Aydın ÇAĞIL
Nihat ÖZER
Yaka Hale YILMAZ
Şükrü AKSOY
Recep ASİLTÜRK
Burak TANGÜREK
Nurten SAYAR
Pages
467–472
Publication Date
2022-11-05
DOI
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Risk factors for CAD were analyzed by a multivariate logistic regression analysis.Results: Genotypical and allelic distribution significantly differed between the two groups (p

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Objective & Hypothesis:Objectives: It has been shown that mutations in the endothelial nitric oxide synthase (eNOS) gene are associated with an increased risk for coronary artery disease (CAD), myocardial infarction, and hypertension.
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Key Findings & Data:We investigated the association of eNOS gene polymorphism (T-786 C) with coronary artery disease in a Turkish population.Study design: The study included 211 patients (144 males, 67 females, mean age 59 years; range 27 to 85 years) who underwent coronary angiography.
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Conclusion & Impact:Risk factors for CAD were analyzed by a multivariate logistic regression analysis.Results: Genotypical and allelic distribution significantly differed between the two groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: It has been shown that mutations in the endothelial nitric oxide synthase (eNOS) gene are associated with an increased risk for coronary artery disease (CAD), myocardial infarction, and hypertension. We investigated the association of eNOS gene polymorphism (T-786 C) with coronary artery disease in a Turkish population.Study design: The study included 211 patients (144 males, 67 females, mean age 59 years; range 27 to 85 years) who underwent coronary angiography. While 159 patients (75.4%) had angiographically shown CAD (≥50% stenosis at least in one vessel), 52 subjects (24.6%) were free of the disease. Those with CAD were classified according to the number of vessels affected. Polymerase chain reaction was used for genotyping. Risk factors for CAD were analyzed by a multivariate logistic regression analysis.Results: Genotypical and allelic distribution significantly differed between the two groups (p

Özet

Amaç: Endotelyal nitrik oksit sentetaz (eNOS) genindeki mutasyonların koroner arter hastalığı (KAH), miyokard infarktüsü ve hipertansiyon için risk faktörü olabileceği gösterilmiştir. Çalışmamızda eNOS gen polimorfizminin (T-786 C) koroner arter hastalığı ile ilişkisi araştırıldı.Çalışma planı: Araştırmaya koroner anjiyografi yapılan 211 hasta (144 erkek, 67 kadın; ort. yaş 59; dağılım 27-85) alındı. Anjiyografide 159 olguda (%75.4) KAH saptandı (en az bir damarda %50 veya daha fazla daralma), 52’sinde (%24.6) KAH yoktu. Koroner arter hastaları, tutulan damar sayısına göre ayrıldı. Genotipleme için polimeraz zincir reaksiyonu yöntemi kullanıldı. Bağımsız risk faktörleri çokdeğişkenli lojistik regresyon analiziyle araştırıldı.Bulgular: Genotip ve allel dağılımı iki grup arasında anlamlı farklılık gösterdi (p

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Cite This Article

AKSU, H., TERZİ, S., ÇİLOĞLU, F., ÇAĞIL, A., ÖZER, N., YILMAZ, Y. H., AKSOY, Ş., ASİLTÜRK, R., TANGÜREK, B., SAYAR, N. (2022). The relationship between endothelial nitric oxide synthase gene polymorphism (T-786 C) and coronary artery disease in a Turkish population. Türk Kardiyoloji Derneği Arşivi, Cilt: 33 - Sayı: 8, 467–472. https://ajindex.com/articles/633763

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