Journals / Türk Kardiyoloji Derneği Arşivi / 2005 / Cilt: 33 - Sayı: 2

The prevalence of coronary artery disease, distribution of lesions, and associated risk factors in patients with chronic renal failure

Kronik böbrek yetmezlikli koroner arter lezyonlarının sıklığı, dağılımı ve risk faktörleri

Pages
90–95
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Treatment should not be delayed especially in the presence of risk factors.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We retrospectively investigated the prevalence of coronary artery disease (CAD), distribution of lesions, and associated risk factors in patients who underwent coronary angiography during treatment of chronic renal failure (CRF).
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Key Findings & Data:Study design: A total of 112 chronic hemodialysis patients (33 women, 79 men; mean age 55.7 years) were examined by coronary angiography for angina or angina-like symptoms, ischemic findings, or for further evaluation before renal transplantation.
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Conclusion & Impact:Treatment should not be delayed especially in the presence of risk factors.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We retrospectively investigated the prevalence of coronary artery disease (CAD), distribution of lesions, and associated risk factors in patients who underwent coronary angiography during treatment of chronic renal failure (CRF). Study design: A total of 112 chronic hemodialysis patients (33 women, 79 men; mean age 55.7 years) were examined by coronary angiography for angina or angina-like symptoms, ischemic findings, or for further evaluation before renal transplantation. Angiographically, significant CAD was defined as the detection of narrowing (50% or more) in at least one coronary artery. Results: Coronary artery disease was detected in 80 patients (71.4%). Patients with CAD exhibited significant differences with regard to age (p=0.002), male gender and the presence of angina (p=0.03), triglyceride level (p=0.02), and diabetes mellitus (p=0.04). Isolated stenosis of the left main coronary artery was detected in one patient (1.3%); 17 (21.3%), 20 (25%), and 42 patients (52.5%) had one-, two-, and three-vessel disease, respectively. The left main coronary artery was involved in four patients (5%), the left anterior descending artery in 70 (87.5%), the circumflex artery in 56 (70%), and the right coronary artery in 57 (71.3%) patients. Though not significant, systolic and diastolic dysfunction of the left ventricle was more common in CAD patients, whereas two groups had a similar left ventricular ejection fraction (p>0.05). Multivariate logistic regression analysis showed that age (p=0.01) and male gender (p=0.02) were independent predictors for CAD. Treatment consisted of monitoring in 21 (26.3%), percutaneous coronary intervention in 15 (18.8%), and coronary artery bypass surgery in 44 (55%) patients. Conclusion: The occurrence of CAD is frequent in patients with CRF, with the lesions showing diffuse involvement. Treatment should not be delayed especially in the presence of risk factors.

Özet

Amaç: Kronik böbrek yetmezliği (KBY) nedeniyle tedavi sırasında koroner anjiyografi yapılan olgularda koroner arter hastalığı (KAH) sıklığı, lezyonların dağılımı ve risk faktörleri geriye dönük olarak araştırıldı.Çalışma planı: Kronik böbrek yetmezliği nedeniyle diyaliz uygulanmakta olan 112 hastaya (33 kadın, 79 erkek; ort. yaş 55.7) angina veya angina benzeri yakınmalar, iskemi bulguları veya böbrek nakli öncesi değerlendirme nedeniyle koroner anjiyografi yapıldı. Anjiyografik olarak anlamlı KAH, en az bir koroner arterde %50 veya üzerinde darlık görülmesi şeklinde tanımlandı. Bulgular: Seksen hastada (%71.4) KAH saptandı; 32 hastada (%28.6) koroner arterler normal bulundu. Koroner arter hastalığı görülen grupta ortalama yaş (p=0.002), erkek cinsiyet ve angina varlığı (p=0.03); lipid parametrelerinden sadece trigliserid düzeyi (p=0.02); aterosklerotik risk faktörlerinden sadece diyabetes mellitus anlamlı farklılık gösterdi (p=0.04). Bir olguda (%1.3) izole sol ana koroner darlığı, 17’sinde (%21.3) tek damar, 20’sinde (%25) iki damar, 42’sinde (%52.5) üç damar lezyonu saptandı. Dört olguda (%5) sol ana koroner, 70 olguda (%87.5) sol ön inen arter, 56 olguda (%70) sirkumfleks arter, 57 olguda (%71.3) sağ koroner arter tutulumu görüldü. Sol ventrikül sistolik ve diyastolik işlev bozuklukları KAH grubunda daha fazla görülürken, sol ventrikül ejeksiyon fraksiyonu iki grupta benzer bulundu (p>0.05). Çok değişkenli lojistik regresyon analizinde yaş (p=0.01) ve erkek cinsiyetin (p=0.02) en önemli KAH belirteçleri olduğu görüldü. Bulgular ışığında, 21 hastanın (%26.3) tıbbi izlemine; 15’inde (%18.8) perkütan koroner girişim, 44’ünde (%55) koroner arter bypas ameliyatı yapılmasına karar verildi.Sonuç: Kronik böbrek yetmezliği olan hastalarda KAH sık görülmekte ve lezyonlar yaygın tutulum göstermektedir. Özellikle risk faktörlerinin varlığında tedavide geç kalınmamalıdır.

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Cite This Article

YILDIRIR, A., ÖZİN, B., ATAR, İ., ELDEM, H. O., AYDINALP, A., MÜDERRİSOĞLU, H., BOZBAŞ, H., KÜÇÜK, M. A., ULUS, T. (2022). The prevalence of coronary artery disease, distribution of lesions, and associated risk factors in patients with chronic renal failure. Türk Kardiyoloji Derneği Arşivi, Cilt: 33 - Sayı: 2, 90–95. https://ajindex.com/articles/633752

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