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Journals / Türk Kardiyoloji Derneği Arşivi / 2008 / Cilt: 36 - Sayı: 8

Romatizmal ve dejeneratif kalp kapak hastalarında doku ve plazma oksidatif stres indeksi

Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease

Ali YILDIZ
Özcan EREL
Rahmi ZEYBEK
Yusuf SEZEN
Murat RABUS
Oğuz KONUKOĞLU
Cevat YAKUT
Recep DEMİRBAĞ
Pages
536–540
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our data show that plasma and tissue OSI levels are similar in patients with rheumatic and degenerative HVD.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We investigated whether patients with rheumatic and degenerative heart valve disease (HVD) differed with regard to plasma and tissue oxidative stress index (OSI).
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Key Findings & Data:Study design: The study included 56 patients who underwent valve replacement due to rheumatic (n=32; 15 males; mean age 47±10 years) and degenerative (n=24; 13 males; mean age 55±12 years) HVD.
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Conclusion & Impact:Conclusion: Our data show that plasma and tissue OSI levels are similar in patients with rheumatic and degenerative HVD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We investigated whether patients with rheumatic and degenerative heart valve disease (HVD) differed with regard to plasma and tissue oxidative stress index (OSI). Study design: The study included 56 patients who underwent valve replacement due to rheumatic (n=32; 15 males; mean age 47±10 years) and degenerative (n=24; 13 males; mean age 55±12 years) HVD. Plasma and tissue total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and OSI was calculated. Results: Patients with degenerative HVD had significantly higher age, increased interventricular septum thickness, and higher frequency of aortic stenosis, whereas the incidence of mitral stenosis was higher in patients with rheumatic HVD (p0.05). Tissue TAC was significantly lower in patients with rheumatic HVD (p=0.027), whereas tissue TOS and OSI were similar between the two HVD groups (p>0.05). In bivariate analysis, plasma OSI did not show any correlation with clinical, laboratory, and echocardiographic variables (p>0.05). Conclusion: Our data show that plasma and tissue OSI levels are similar in patients with rheumatic and degenerative HVD.

Özet

Amaç: Bu çalışmada, romatizmal ve dejeneratif kalp kapak hastalığında (KKH) plazma ve doku oksidatif stres indeksi (OSİ) açısından farklılık olup olmadığı araştırıldı. Ça lış ma pla nı: Çalışmaya kapak replasmanı yapılan 56 hasta alındı. Bunların 32’sinde (15 erkek; ort. yaş 47±10) romatizmal, 24’ünde (13 erkek; ort. yaş 55±12) dejeneratif KKH vardı. Plazma ve dokuda total oksidatif durum (TOD) ve total antioksidan kapasite (TAK) seviyeleri ölçüldü ve OSİ hesaplandı. Bul gu lar: Dejeneratif KKH grubunda yaş, interventriküler septum kalınlığı ve aort darlığının sıklığı anlamlı derecede fazlaydı; romatizmal KKH grubunda ise mitral darlığı sıklığı daha yüksek bulundu (p0.05). Doku örneklerinde ise, romatizmal KKH grubunda TAK anlamlı derecede daha düşük bulunurken (p=0.027), TOD ve OSİ değerleri iki grupta benzerdi (p>0.05). İkili korelasyon analizinde, incelenen hiçbir klinik, laboratuvar ve ekokardiyografik parametre OSİ ile anlamlı ilişki göstermedi (p>0.05). So nuç: Bulgularımız, plazma ve doku OSİ seviyelerinin romatizmal ve dejeneratif KKH’de benzer olduğunu göstermektedir.

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Cite This Article

YILDIZ, A., EREL, Ö., ZEYBEK, R., SEZEN, Y., RABUS, M., KONUKOĞLU, O., YAKUT, C., DEMİRBAĞ, R. (2022). Romatizmal ve dejeneratif kalp kapak hastalarında doku ve plazma oksidatif stres indeksi. Türk Kardiyoloji Derneği Arşivi, Cilt: 36 - Sayı: 8, 536–540. https://ajindex.com/articles/633491

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