Journals / Türk Kardiyoloji Derneği Arşivi / 2009 / Cilt: 37 - Sayı: 6

İntihar amaçlı propafenon ve trimetoprim/sulfametoksazol alımı ile akut zehirlenme

Acute intoxication with propafenone and trimethoprim-sulfamethoxazole in a case of suicide attempt

Pages
410–413
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

He was discharged with an appropriate hemodynamic balance on the third day with normal ECG findings.

📌 3 Key Takeaways

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Objective & Hypothesis:A 17-year-old male ingested about 20 tablets of propafenone (total 6,000 mg) and 24 tablets of trimethoprim (total 1,920 mg) - sulfamethoxazole (total 9,600 mg) with suicidal intent.
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Key Findings & Data:On admission, his heart rate was regular with 55 beats/min and blood pressure was 70/45 mmHg.
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Conclusion & Impact:He was discharged with an appropriate hemodynamic balance on the third day with normal ECG findings.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A 17-year-old male ingested about 20 tablets of propafenone (total 6,000 mg) and 24 tablets of trimethoprim (total 1,920 mg) - sulfamethoxazole (total 9,600 mg) with suicidal intent. Within one hour, he was brought to a hospital with vomiting, nausea, and loss of consciousness, where he developed cyanosis and mild acidosis, and eventually cardiorespiratory arrest, despite bicarbonate, saline infusion, and inotropic support. Fortunately, he was fully resuscitated and ventilated, and sinus rhythm was restored. He was then transported to our center. On admission, his heart rate was regular with 55 beats/min and blood pressure was 70/45 mmHg. The 12-lead electrocardiogram (ECG) showed sinus bradycardia, extreme widening of the QRS complex (260 msec) with a right bundle branch block pattern. Intravenous saline, bicarbonate, and dopamine were administered, and respiration was supported mechanically, which resulted in rapid restoration of sinus rhythm and improvement in hemodynamic parameters and acidosis. A subsequent ECG showed shortening of the QRS duration (230 msec). He was discharged with an appropriate hemodynamic balance on the third day with normal ECG findings.

Özet

On yedi yaşındaki bir erkek hasta, intihar amacıyla yaklaşık 20 tablet (toplam 6000 mgr) propafenon ve 24 tablet trimetoprim (toplam 1920 mgr)-sulfametoksazol (toplam 9600 mgr) içtikten sonra bir saat içinde, kusma, bulantı ve bilinç kaybıyla başka bir merkeze getirildi. Burada, uygulanan bikarbonat, salin infüzyonu ve inotropik desteğe rağmen hastada siyanoz, orta derecede asidoz ve sonuçta kardiyorespiratuvar arest gelişti. Hasta başarılı resüsitasyon ve ventilasyon girişimleriyle yaşama döndürüldükten ve sinüs ritmine döndükten sonra merkezimize sevk edildi. İlk muayenede kalp hızı düzenli ve 55 atım/dk, kan basıncı 70/45 mmHg olan hastanın 12 derivasyonlu elektrokardiyografisinde sinüs bradikardi, aşırı derecede genişlemiş QRS kompleksi (260 msn) ve sağ dal bloku paterni izlendi. İntravenöz salin, bikarbonat ve dopamin tedavisi ve mekanik solunum desteğiyle hastanın sinüs ritmi, hemodinamik parametreleri ve asidozu hızla düzeldi. Elektrokardiyogramda QRS süresinin azaldığı (230 msn) görüldü. Üçüncü günde yeterli hemodinamik dengesi sağlanan hasta normal elektrokardiyografik bulgularla taburcu edildi.

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Cite This Article

ARDIÇ, İ., YARLIOGLIES, M., KAYA, M. G., GÜNEBAKMAZ, Ö. (2022). İntihar amaçlı propafenon ve trimetoprim/sulfametoksazol alımı ile akut zehirlenme. Türk Kardiyoloji Derneği Arşivi, Cilt: 37 - Sayı: 6, 410–413. https://ajindex.com/articles/633399

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