Journals / Tıp Araştırmaları Dergisi / 2007 / Cilt: 5 - Sayı: 3

Infective endocarditis: retrospective evaluation of 27 patients

İnfektif endokardit: retrospektif olarak 27 hastanın değerlendirilmesi

Pages
91–99
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CHF and high CRP levels predict in-hospital mortality.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Infective endocarditis (IE) is a microbial infection of the endothelial surface of the heart.
📊
Key Findings & Data:Methods: A retrospective analysis of the patients with infective endocarditis as defined by modifies Duke Criteria between March 2005 and August 2007 was performed at the Erciyes University.
💡
Conclusion & Impact:CHF and high CRP levels predict in-hospital mortality.
🔬Design:Research Article
📍Scope:2005 Verileri
⚙️Variables:Endokardit · Hastane ölüm oranı · Seyir

Abstract

Objectives: Infective endocarditis (IE) is a microbial infection of the endothelial surface of the heart. In this study, our aim was to evaluate predictors of inhospital mortality, complications and prognosis in patients with infective endocarditis. Methods: A retrospective analysis of the patients with infective endocarditis as defined by modifies Duke Criteria between March 2005 and August 2007 was performed at the Erciyes University. The clinical, echocardiographic and follow-up data were extracted from the hospital records. Results: Twenty seven patients (17 men and 10 women, mean age 47±17) with infective endocarditis were retrospectively studied. Sixteen patients hadnative valve endocarditis and eleven patients had prosthetic valve endocarditis. Coagulase negative staphylococcus 2 3 . 0% was the most common causative organism. In hospital period, 4 patients (14.8%) died. Mortality was not significantly different between native valve IE and prosthetic valve IE patients ( 1 3 % v 18%, respectively, p=0.683). Complication rate was 4 8 % in patients with IE. Congestive heart failure was the most common complication. Congestive heart failure (CHF) ( 7 5% v 17%, p=0.015), NYHA class III-IV ( 7 5 % v 17%, p=0.015) and high CRP levels (78±50 v 134±17, p=0.042) associated in-hospital mortality. Conclusion: IE not only carries a high in-hospital mortality risk but also is associated with high complications. CHF and high CRP levels predict in-hospital mortality.

Özet

Amaç: İnfektif endokardit (İE) kalbin endokardiyal yüzeyinin mikrobiyal infeksiyonudur. Bu çalışmada amacımız, infektif endokarditli hastalarda prognozu, komplikasyonları ve hastane içi ölümleri belirleyen faktörleri değerlendirmektir. Gereç ve Yöntem: Erciyes Üniversitesinde Mart 2005 ile Ağustos 2007 tarihleri arasında modifiye Duke kriterlerine uyan 27 hasta retrospektif olarak çalışmaya alındı. Hastaların klinik, ekokardiyografi ve hastane içi takip verilerine hastane kayıtlarından ulaşıldı. Bulgular: İnfektif endokardit tanısı alan 27 hasta (17'si erkek ve 10fu bayan, ortalama yaş 47±17) çalışmaya alındı. On altı hasta nativ kapak endokarditi; on bir hasta ise prostetik kapak endokarditi idi. İE'e en sık koagülaz negatif stafilokokların (%23) neden olduğu görüldü. Hastane içi dönem takibinde 4 hastada (%14.8) mortalite izlendi. Nativ ve prostetik kapak İE'li hastalar arasında mortalite açısından anlamlı fark bulunmadı (%13'e karşılık %18, p=0.683). İE'li hastalarda komplikasyon oranı %8 olarak saptandı ve en sıkgörülen komplikasyonun konjestif kalp yetmezliği olduğu belirlendi. Hastane içi ölümlerini belirleyen en önemli faktörlerin; konjestif kalp yetmezliği (%75fe karşılık %17, p=0.015), NYHA Klass III-IV (%75'e karşılık %17, p=0.015) ve yüksek CRP düzeyleri (78±50'e karşılık 134±17, p=0.042) olduğu görüldü. Sonuç: İnfektif endokardit hem hastane içi mortalitesi hem de komplikasyon oranı yüksek bir hastalıktır. Konjestif kalp yetmezliği ve CRP yüksekliği, hastane içi dönemde artmış mortalite riskini gösteren en önemli prognostik faktörlerdir.

🔖

Cite This Article

İNANÇ, T., KAYA, M. G., KAYA, E. G., DOĞAN, A., ARDIÇ, I., DOĞDU, O., AKSU, R., ÖZDOĞRU, İ. (2007). Infective endocarditis: retrospective evaluation of 27 patients. Tıp Araştırmaları Dergisi, Cilt: 5 - Sayı: 3, 91–99. https://ajindex.com/articles/356284

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Fink AM. Endocarditis after valve replacement surgery. Early recognition and treatment are essential to averting deadly complications. AJN 2006; 106 (2): 40 51
  2. Cecchi E, Forno D. New trends in the epidemiological and clinical features of infective endocarditis: results of a multicenter prospective study. Ital Heart Journal 2004; 5: 249-256
  3. Tornos P, lung B, Permanyer-Miralda G, et al. Infective endocarditis in Europe: lessons from the Euro heart survey. Heart 2005; 91:571-575
  4. Watanakunakorn C, Burkert T: Infective endocarditis at a large community teaching hospital, 1980-1990. A review of 210 episodes. Medicine (Baltimore) 1993, 72:90-102
  5. Netzer ROM, Zollinger E, Seiler C, Cerny A: Infective endocarditis: clinical spectrum, presentation and outcome. An analysis of 212 cases 1980-1995. Heart 2000, 84:25-30
  6. Hoen B, Alia F, Selton-Suty C, et al. Changing profile of infective endocarditis. Results of a 1-year survey in France. JAMA 2002, 288:75-81
  7. Baddour LM, Wilson WR, Bayer AS, et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation 2005; 111: 394-434
  8. Li JS, Sexton DJ, Mick N, et al.Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000; 30: 633-638
  9. Moreillon P, Que YA. Infective endocarditis. Lancet 2004; 363: 139-149
  10. Mylonakis E, Calderwood SB. Medical progress: Infective endocarditis in adults. N Eng J Med 2001;345: 1318-1340
  11. Netzer RO, Altwegg SC, Zollinger E, Tauber M, Carrel T, Seiler C. Infective endocarditis: determinants of long term outcome. Heart 2002; 88:61-66
  12. Habib G, Tribouilloy C, Thuny F, et al. Prosthetic valve endocarditis: who needs surgery? A multicentre study of 104 cases. Heart 2005; 91:954-959
  13. Yavuz SS, Eren M, Yavuz A, et al. İnfektif Endokardit: 58 olgunu değerlendirilmesi. Klimik dergisi 2003; 16: 55-62
  14. Koçak F, Yavuz SŞ. Brucella spp.'ye bağlı doğal ve yapay kapak endokarditi; Sekiz olgunun değerlendirilmesi. Flora dergisi 2005; 10: 38-42
  15. Karchmer AW. Infective endocarditis. In: Zipes DP, Libby P, Bonow RO, Braunwald E, et al