AI Summary & Key Takeaways
AI InsightIn correlation anal- ysis, Pmax was significantly correlated with aortic strain (r= -0.30, p=0.01), aortic distensibility (r=-0.27, p=0.02), aortic stiffness index (r=0.36, p=0.004), and aortic elas- tic modulus (r=0.38, p=0.003), while PWD was correlat- ed with aortic strain (r= -0.23, p=0.05) and aortic elastic modulus (r=0.25, p=0.05).Conclusion: Our data showed that isolated BAV with- out valve dysfunction was associated with prolonged P- wave duration and increased PWD, both of which were related to aortic elasticity parameters.
📌 3 Key Takeaways
Abstract
Objectives: We evaluated P-wave duration and P-wave dispersion (PWD) in patients with isolated bicuspid aor- tic valve (BAV) without significant valve dysfunction and investigated the relationship between P-wave measure- ments and aortic elasticity.Study design: This prospective study consisted of 39 pa- tients with isolated BAV with normal ejection fraction and 29 age- and gender-matched healthy subjects. P-wave duration and P-wave dispersion were calculated on 12- lead electrocardiograms. Echocardiographic examina- tion was performed and aortic elasticity parameters were calculated including aortic strain, aortic stiffness index, aortic distensibility, and aortic elastic modulus.Results: Patients with BAV had significantly greater Pmax and PWD compared to controls (128±11 vs. 115±11 msec, p=0.006; 70±10 vs. 66±13 msec, p=0.02, respec- tively), whereas Pmin was similar. Aortic strain and disten- sibility were significantly lower and aortic stiffness index and aortic elastic modulus were significantly greater in patients with BAV (for all, p= 0.0001). In correlation anal- ysis, Pmax was significantly correlated with aortic strain (r= -0.30, p=0.01), aortic distensibility (r=-0.27, p=0.02), aortic stiffness index (r=0.36, p=0.004), and aortic elas- tic modulus (r=0.38, p=0.003), while PWD was correlat- ed with aortic strain (r= -0.23, p=0.05) and aortic elastic modulus (r=0.25, p=0.05).Conclusion: Our data showed that isolated BAV with- out valve dysfunction was associated with prolonged P- wave duration and increased PWD, both of which were related to aortic elasticity parameters.
Özet
Amaç:Bu çalışmada, kapak işlevinde önemli bozukluk olmayan izole biküspit aort kapaklı (BAK) hastalarda P dalga süresi ve P dalga dispersiyonu değerlendirildi ve P dalga ölçümleri ile aort esneklik parametreleri arasındaki ilişki araştırıldı. Çalışma planı: İleriye dönük bu çalışmaya izole BAV olan ve ejeksiyon fraksiyonu normal 39 hasta ve yaş ve cinsiyet uyumlu 29 sağlıklı birey alındı. P dalga süresi ve P dalga dispersiyonu 12 derivasyonlu elektrokardiyografi kayıtlarından hesaplandı. Tüm olgulara ayrıntılı ekokardiyografi incelemesi yapıldı ve aort gerilimi, aort sertlik indeksi, aort gerilebilirliği ve aort esneklik katsayısı gibi aort esneklik parametreleri hesaplandı. ,Bulgular: En yüksek P dalga süresi ve P dalga dispersiyonu hasta grubunda kontrol grubuna göre anlamlı derecede yüksek bulundu (sırasıyla, 128±11 ve 115±11 msn, p=0.006; 70±10 ve 66±13 msn, p=0.02); en düşük P dalga süresi ise benzerdi. Hasta grubunda aort gerilimi ve aort gerilebilirliği anlamlı derecede düşük, aort sertlik indeksi ve aort esneklik katsayısı anlamlı derecede yüksek idi (tümü için p=0.0001). Korelasyon analizinde en yüksek P dalga süresi aort gerilimi (r=-0.30, p=0.01), aort gerilebilirliği (r=-0.27, p=0.02), aort sertlik indeksi (r=0.36, p=0.004) ve aort esneklik katsayısı (r=0.38, p=0.003) ile, P dalga dispersiyonu ise aort gerilimi (r=-0.23, p=0.05) ve aort esneklik katsayısı (r=0.25, p=0.05) ile anlamlı ilişki gösterdi. Sonuç: Bulgularımız, kapak fonksiyonu normal izole BAK hastalarında P dalga süresi ve dispersiyonunda artış olduğunu, bunların her ikisinin de aort esneklik parametreleri ile ilişkili olduğunu gösterdi.