SavedAdd your journal

Journals / Türk Kardiyoloji Derneği Arşivi / 2017 / Cilt: 45 - Sayı: 1

Relationship between serum osteopontin level and atrial fibrillation recurrence in patients undergoing cryoballoon catheter ablation

Kriyobalon kateter ablasyonu uygulanan hastalarda serum osteopontin seviyeleri ile atriyum fibrilasyonu nüksü arasındaki ilişki

Mehmet Onur OMAYGENÇ
Hacı Murat GÜNEŞ
Ayşe İstanbullu TOSUN
Bilal BOZTOSUN
Gültekin Günhan DEMİR
Fethi KILIÇARSLAN
Gamze Babur GÜLER
Taylan AKGÜN
Filiz Kızılırmak YILMAZ
Ekrem GÜLER
Pages
26–32
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Postprocedure osteopontin level was significantly higher compared with preprocedure value (32.18 ng/mL vs 15.58 ng/mL; p=

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with increased morbidity and mortality.
📊
Key Findings & Data:Atrial fibrosis augments recurrence rate following AF catheter ablation.
💡
Conclusion & Impact:Postprocedure osteopontin level was significantly higher compared with preprocedure value (32.18 ng/mL vs 15.58 ng/mL; p=
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with increased morbidity and mortality. Atrial fibrosis augments recurrence rate following AF catheter ablation. Osteopontin is a multifunctional molecule involved in several pathophysiological pathways, including fibrosis. Presently described is investigation of relationship between serum osteopontin level and AF recurrence after AF cryoablation.Methods: The study was designed to be prospective and observational; 60 patients with paroxysmal (n=47) and persistent (n=13) AF were included. Osteopontin level was measured both before and 6 months after AF ablation with cryoballoon.Results: Preprocedure and postprocedure osteopontin level did not differ between the 2 groups of AF patients (p=0.286, p=0.493, respectively). Postprocedure osteopontin level was significantly higher compared with preprocedure value (32.18 ng/mL vs 15.58 ng/mL; p=

Özet

Amaç: Atriyum fibrilasyonu (AF) mortalite ve morbidite artışı ile ilişkili en sık rastlanan ritm bozukluğudur. Atriyum fibrozu, AF'nin kateter ablasyonu sonrası nüks oranını artırır. Osteopontin, fibrozu da içeren çeşitli fizyopatololojik süreçlerde görev alan çok fonksiyonlu bir moleküldür. Atriyum fibrilasyonu kriyoablasyonu sonrasında serum osteopontin seviyeleri ile AF nüksü arasındaki ilişkiyi araştırdık.Yöntemler: Çalışmamız ileriye dönük ve gözlemsel olarak tasarlandı; nöbetli (n=47) ve sürekli (n=13) AF'si olan 60 hasta çalışmaya dahil edildi. Serum osteopontin seviyeleri AF kriyoablasyonu işlem öncesi ve işleminden altı ay sonra ölçüldü.Bulgular: İki AF hasta grubuna göre işlem öncesi ve sonrası osteopontin seviyeleri arasında farklılık saptanmadı (sırasıyla, p=0.286, p=0.493). İşlem sonrası osteopontin seviyeleri, işlem öncesi seviye ile kıyaslandığında anlamlı olarak yüksekti (32.18 ng/mL ve 15.58 ng/mL; p=

🔖

Cite This Article

OMAYGENÇ, M. O., GÜNEŞ, H. M., TOSUN, A. İ., BOZTOSUN, B., DEMİR, G. G., KILIÇARSLAN, F., GÜLER, G. B., AKGÜN, T., YILMAZ, F. K., GÜLER, E. (2022). Relationship between serum osteopontin level and atrial fibrillation recurrence in patients undergoing cryoballoon catheter ablation. Türk Kardiyoloji Derneği Arşivi, Cilt: 45 - Sayı: 1, 26–32. https://ajindex.com/articles/632315

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Ryder KM, Benjamin EJ. Epidemiology and significance of atrial fibrillation. Am J Cardiology 1998;84:131-8
  2. Wang TJ, Larson MG, Levy D, Vasan RS, Leip EP, Wolf PA, et al. Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation 2003;107:2920-5
  3. Evranos B, Aytemir K, Oto A, Okutucu S, Karakulak U, Şahiner L, et al. Predictors of atrial fibrillation recurrence after atrial fibrillation ablation with cryoballoon. Cardiol J 2013;20:294-303
  4. Güler E, Güler GB, Demir GG, Kizilirmak F, Güneş HM, Barutçu I, et al. Effect of Pulmonary Vein Anatomy and Pulmonary Vein Diameters on Outcome of Cryoballoon Catheter Ablation for Atrial Fibrillation. Pacing Clin Electrophysiol 2015;38:989-96
  5. Dewire J, Khurram IM, Pashakhanloo F, Spragg D, Marine JE, Berger RD, et al. The association of pre-existing left atrial fibrosis with clinical variables in patients referred for catheter ablation of atrial fibrillation. Clin Med Insights Cardiol 2014;8(Suppl 1):25-30
  6. Ausma J, Wijffels M, Thoné F, Wouters L, Allessie M, Borgers M. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation 1997;96:3157-63
  7. Cho HJ, Cho HJ, Kim HS. Osteopontin: a multifunctional protein at the crossroads of inflammation, atherosclerosis, and vascular calcification. Curr Atheroscler Rep 2009;11:206-13
  8. Gunes HM, Guler GB, Guler E, Demir GG, Hatipoglu S, Zehir R, et al. Impact of valve surgery on serum osteopontin levels in patients with mitral regurgitation. Cardiology 2015;130:82-6
  9. Grammer JB, Böhm J, Dufour A, Benz M, Lange R, Bauernschmitt R. Atrial fibrosis in heart surgery patients Decreased collagen III/I ratio in postoperative atrial fibrillation. Basic Res Cardiol 2005;100:288-94
  10. Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, et al. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace 2012;14:528-606
  11. Boos CJ, Anderson RA, Lip GY. Is atrial fibrillation an inflammatory disorder? Eur Heart J 2006;27:136-49
  12. Verma A, Wazni OM, Marrouche NF, Martin DO, Kilicaslan F, Minor S, et al. Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: an independent predictor of procedural