Journals / Türk Kardiyoloji Derneği Arşivi / 2019 / Cilt: 47 - Sayı: 8

Subclinical myocardial dysfunction in liver transplant candidates determined using speckle-tracking imaging

Karaciğer transplantasyonu adaylarında benek takibi görüntüleme ile belirlenen subklinik miyokart disfonksiyonu

Pages
638–645
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This deterioration was detected in longitudinal and radial deformation rather than circumferential deformation mechanics, which is consistent with earlystage LV myocardial dysfunction.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: There are various cardiovascular abnormalities in end-stage liver disease (ESLD).
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Key Findings & Data:In these patients, left ventricular (LV) systolic function is normal at rest but deteriorates during stress.
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Conclusion & Impact:This deterioration was detected in longitudinal and radial deformation rather than circumferential deformation mechanics, which is consistent with earlystage LV myocardial dysfunction.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: There are various cardiovascular abnormalities in end-stage liver disease (ESLD). In these patients, left ventricular (LV) systolic function is normal at rest but deteriorates during stress. This deterioration may be due to subclinical myocardial dysfunction. This study evaluated global LV and right ventricular (RV) functions using 2-dimensional (2D) speckle tracking in patients with ESLD.Methods: Forty liver transplant candidates with ESLD and 26 healthy individuals were included in the study. All of the patients underwent conventional echocardiographic measurement. Longitudinal, circumferential, and radial strain measurements, as well as apical and parasternal short-axis image recordings were obtained. All 2D strain measurements were measured with offline analysis using velocity vector imaging (VVI) software.Results: In the apical 4- and 2-chamber measurements, the LV mean longitudinal strain was significantly lower in the patient group compared with that of the control group(-16.0±3.2% versus -17.6±2.2%, -16.7±3.3% versus -18.7 ±2.1 ± 2.1 %; p=0.002, respectively). The LV mean circumferential strain did not differ between groups. The LV mean radial strain and RV longitudinal strain were significantly lower in the patient group (45.4±10.7 vs. 52.7±10.8%; p=0.01 and -19.2±3.5% versus -21.5±3.6%; p=0.03, respectively).Conclusion: Subclinical impairment of global LV and RV systolic functions was determined in liver transplantation candidates using VVI. This deterioration was detected in longitudinal and radial deformation rather than circumferential deformation mechanics, which is consistent with earlystage LV myocardial dysfunction.

Özet

Amaç: Son dönem karaciğer hastalarında (SDKH) çeşitli kardiyovasküler anormallikler olduğu bilinmektedir. Bu hastalarda istirahatte sol ventrikül (LV) sistolik fonksiyonu normal saptanmasına karşın stres sırasında bozulmaktadır. Bu bozulma subklinik miyokardiyal işlev bozukluğundan kaynaklanıyor olabilir. Bu nedenle, bu çalışmada SDKH’da global LV ve sağ ventrikül (RV) fonksiyonlarını 2 boyutlu (2B) benek takibi görüntüleme yöntemi ile değerlendirmesi amaçlandı.Yöntemler: Karaciğer nakil adayı olan 40 SDKH ile 26 sağlıklı birey çalışmaya dahil edildi. Tüm hastaların standart ekokardiyografik ölçümleri yapıldı. Uzunlamasına, sirkümferansiyel ve radyal strain ölçümleri için apikal ve parasternal kısa eksen görüntü kayıtları alındı. Tüm 2B strain ölçümleri alınan kayıtlardan, çevrim dışı analiz ile hız vektör görüntüleme (VVI) yazılım paketi kullanılarak ölçüldü.Bulgular: Apikal 4- ve 2- boşluk ölçümlerde, LV ortalama uzunlamasına strain değeri, hasta grubunda kontrol grubuna göre anlamlı olarak daha düşüktü (-16.0 %3.2 ve -17.6±%2.2, p=0.03 ve -16.2±%3.3 ve -18.7±%2.1, p=0.002). LV ortalama sirkumferansiyel strain değerlerinde gruplar arasında fark saptanmazken, LV ortalama radyal strain ve RV uzunlamasına strain değerleri hasta grubunda anlamlı derecede daha düşük saptandı (45.4±10.7 ve %52.7±10.8, p=0.01 ve -19.2±%3.5 ve -21.5±%3.6, p=0.03).Sonuç: Karaciğer nakil adaylarında, VVI yöntemi ile global LV ve RV sistolik fonksiyonlarında subklinik bozulma tespit edildi. Bu bozulma, LV’de miyokart hasarının erken evrede olmasıyla tutarlı olan sirkumferansiyel deformasyon mekaniğinden ziyade uzunlamasına ve radyal deformasyonda saptandı.

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Cite This Article

PAMUKCU, H. E., ALTIN, C., YILMAZ, S., İNCİ, S. D., MÜDERRİSOĞLU, H., PİRAT, B., SADE, L. E. (2022). Subclinical myocardial dysfunction in liver transplant candidates determined using speckle-tracking imaging. Türk Kardiyoloji Derneği Arşivi, Cilt: 47 - Sayı: 8, 638–645. https://ajindex.com/articles/632085

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