Journals / Journal of Surgery and Medicine / 2020 / Cilt: 4 - Sayı: 10

Psoriatic arthritis is associated with myocardial repolarization dysregulation as assessed by the QTc interval and the Tp-e/QTc ratio

Psöriatik artrit, QTc aralığı ve Tp-e/QTc oranı ile değerlendirilen miyokardiyal repolarizasyon düzensizliği ile ilişkilidir

Pages
887–890
Publication Date
2020-10-01
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The median Tp-e/QTc ratio of the patients with PsA was significantly higher than the median Tp-e/QTc ratio of the control group (0.21 (0.20-0.25) vs. 0.18 (0.17-0.19, P

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: An increased risk of arrhythmia has been shown in patients with psoriatic arthritis (PsA).
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Key Findings & Data:Methods: This cross-sectional observational study included patients with psoriatic arthritis who were over 18 years of age.
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Conclusion & Impact:The median Tp-e/QTc ratio of the patients with PsA was significantly higher than the median Tp-e/QTc ratio of the control group (0.21 (0.20-0.25) vs. 0.18 (0.17-0.19, P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Psoriatik artrit · Elektrokardiyografi · Tp-e/QTc oranı

Abstract

Aim: An increased risk of arrhythmia has been shown in patients with psoriatic arthritis (PsA). Tp-e interval and Tp-e/QT ratio are considered useful markers for the assessment of myocardial repolarization heterogeneity. In present study we aim to investigate the characteristics of ventricular repolarization on the basis of QTc interval and Tp-e/QTc ratio in patients PsA. Methods: This cross-sectional observational study included patients with psoriatic arthritis who were over 18 years of age. A control group was created with healthy volunteers. The diagnosis of psoriatic arthritis were done according to the CASPAR criteria. QT interval, corrected QT (QTc), Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were measured from the 12-lead electrocardiograms(ECG) of the PsA patients and control group. Results: The study population consisted of 82 patients with PsA and 82 healthy volunteers. According to electrocardiographic parameters the heart rate was similar in both groups, but QT, QTc, Tp-e intervals; Tp-e /QT and Tp-e/ QTc ratios were significantly higher in the PsA group. The median Tp-e/QTc ratio of the patients with PsA was significantly higher than the median Tp-e/QTc ratio of the control group (0.21 (0.20-0.25) vs. 0.18 (0.17-0.19, P

Özet

Amaç: Psoriatik artritli (PsA) hastalarda aritmi riski artışı olduğu gösterilmiştir. Tp-e aralığı ve Tp-e/QT oranı, miyokardiyal repolarizasyon heterojenitesinin değerlendirilmesinde yararlı belirteçler olarak kabul edilmektedir. Bu çalışmada PsA hastalarında QTc aralığı ve Tp-e/QTc oranı temelinde ventriküler repolarizasyonun özelliklerini incelemeyi amaçladık. Yöntemler: Bu kesitsel gözlemsel çalışmaya 18 yaşın üzerinde psoriatik artritli hastalar dahil edildi. Sağlıklı gönüllülerden bir kontrol grubu oluşturuldu. Psoriatik artrit tanısı CASPAR kriterlerine göre yapıldı. PsA hastalarının ve kontrol grubunun 12 kanallı elektrokardiyogramlarından (EKG) QT aralığı, düzeltilmiş QT (QTc), Tp-e aralığı, Tp-e/QT oranı ve Tp-e/QTc oranı ölçüldü. Bulgular: Çalışma popülasyonu 82 PsA hastası ve 82 sağlıklı gönüllüden oluşuyordu. Elektrokardiyografik parametrelere göre kalp hızı her iki grupta da benzerdi, ancak QT, QTc, Tp-e aralıkları; Tp-e/QT ve Tp-e/QTc oranları PsA grubunda anlamlı olarak yüksekti. PsA'lı hastaların medyan Tp-e/QTc oranı, kontrol grubunun medyan Tp-e/QTc oranından (0,21 (0,20-0,25) ve 0,18 (0,17-0,19, P

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Cite This Article

PAMUKCU, H. E., PAMUKCU, M. (2020). Psoriatic arthritis is associated with myocardial repolarization dysregulation as assessed by the QTc interval and the Tp-e/QTc ratio. Journal of Surgery and Medicine, Cilt: 4 - Sayı: 10, 887–890. https://ajindex.com/articles/780223

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References (10)

  1. Feld J, Weiss G, Rosner I, Rozenbaum M, Laor A, Rimar D, et al. Electrocardiographic findings in psoriatic arthritis: a case-controlled study. J Rheumatol. 2008;35(12):2379-82. Epub 2008/10/10. doi: 10.3899/jrheum.080314. PubMed PMID: 18843776
  2. Shbeeb M, Uramoto KM, Gibson LE, O'Fallon WM, Gabriel SE. The epidemiology of psoriatic arthritis in Olmsted County, Minnesota, USA, 1982-1991. J Rheumatol. 2000;27(5):1247-50. Epub 2000/05/17. PubMed PMID: 10813295
  3. Wilson FC, Icen M, Crowson CS, McEvoy MT, Gabriel SE, Kremers HM. Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study. Arthritis Rheum. 2009;61(2):233-9. Epub 2009/01/30. doi: 10.1002/art.24172. PubMed PMID: 19177544; PubMed Central PMCID: PMCPMC3061343
  4. Husni ME, Mease PJ. Managing comorbid disease in patients with psoriatic arthritis. Current rheumatology reports. 2010;12(4):281-7. doi: 10.1007/s11926-010-0112-3. PubMed PMID: 20589485
  5. Horreau C, Pouplard C, Brenaut E, Barnetche T, Misery L, Cribier B, et al. Cardiovascular morbidity and mortality in psoriasis and psoriatic arthritis: a systematic literature review. Journal of the European Academy of Dermatology and Venereology: JEADV. 2013;27 Suppl 3:12-29. doi: 10.1111/jdv.12163. PubMed PMID: 23845149
  6. Jamnitski A, Symmons D, Peters MJ, Sattar N, McInnes I, Nurmohamed MT. Cardiovascular comorbidities in patients with psoriatic arthritis: a systematic review. Annals of the rheumatic diseases. 2013;72(2):211-6. doi: 10.1136/annrheumdis-2011-201194. PubMed PMID: 22532629
  7. Markuszeski L, Bissinger A, Janusz I, Narbutt J, Jedrzejowska AS, Zalewska A. Heart rate and arrhythmia in patients with psoriasis vulgaris. Arch Med Res. 2007;38(1):64-9. Epub 2006/12/19. doi: 10.1016/j.arcmed.2006.08.004. PubMed PMID: 17174725
  8. Gaydukova I, Rebrov A, Nikitina N, Poddubnyy D. Decreased heart rate variability in patients with psoriatic arthritis. Clinical rheumatology. 2012;31(9):1377-81. doi: 10.1007/s10067-012-2015-3. PubMed PMID: 22673792
  9. Arisoy A, Karaman K, Karayakali M, Demirelli S, Seckin HY, Celik A, et al. Evaluation of ventricular repolarization features with novel electrocardiographic parameters (Tp-e, Tp-e/QT) in patients with psoriasis. Anatol J Cardiol. 2017;18(6):397-401. Epub 2017/12/20. doi: 10.14744/AnatolJCardiol.2017.7901. PubMed PMID: 29256874; PubMed Central PMCID: PMCPMC6282903
  10. Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H, et al. Cl