Serum total sialic acid levels and sialic acid acetyl esterase gene variation

Objective & Hypothesis:Objective: To evaluate the role of serum total sialic acid (SA) levels and sialic acid acetyl esterase (SIAE) gene variation in etiopathogenesis of preeclampsia (PE).

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Key Findings & Data:Design: Prospective study Setting: Gaziantep Üniversity, Medical School, Department of Obstetrics and Gynecology Patients: This study was performed with 57 preeclamptic pregnant women and 50 pregnant women having no medical problems who has admitted to the Department of Obstetrics and Gynecology of Gaziantep University Medical Faculty between January 2008 and June 2008 Main outcome measures: Serum total SA levels were measured by Denny's colorimetric method and analysis of SIAE gene variation was performed by polymerase chain reaction -single stranded conformational polymorphism (PCR-SSCP).

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Conclusion & Impact:Statistical analyses were achieved using the SPSS 13.0 software.

🔬Design:Research Article

📍Scope:2008 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: To evaluate the role of serum total sialic acid (SA) levels and sialic acid acetyl esterase (SIAE) gene variation in etiopathogenesis of preeclampsia (PE). Design: Prospective study Setting: Gaziantep Üniversity, Medical School, Department of Obstetrics and Gynecology Patients: This study was performed with 57 preeclamptic pregnant women and 50 pregnant women having no medical problems who has admitted to the Department of Obstetrics and Gynecology of Gaziantep University Medical Faculty between January 2008 and June 2008 Main outcome measures: Serum total SA levels were measured by Denny's colorimetric method and analysis of SIAE gene variation was performed by polymerase chain reaction -single stranded conformational polymorphism (PCR-SSCP). Statistical analyses were achieved using the SPSS 13.0 software. P

Özet

Objektif: Preeklampsi (PE) etiyopatogenezinde serum sialik asit (SA) seviyesi ve sialik asit esteraz (SiAE) gen varyasyonunun yerinin ortaya konulması Planlama: Prospektif Ortam: Gaziantep Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı Hastalar: Çalıﬂmaya Ocak-Haziaran 2008 tarihleri arasında kliniğimize baﬂvuran, 28-40 hafta arası 57 preeklamptik gebe ile herhangi bir medikal problemi olmayan 50 sağlıklı gebe dahil edimiﬂtir Değerlendirme parametreleri: Serum total SA seviyesi Denny'nin kolorimetrik metodu kullanılarak değerlendirilmiﬂtir. SiAE gen varyasyon analizi, ilgili genin promotor bölgesi için tarafımızdan dizayn edilen primerler kullanılarak polymerase chain reaction -single stranded conformational polymorphism (PCR-SSCP) yöntemi ile gerçekleﬂtirilmiﬂtir. Çalıﬂmada elde edilen veriler SPSS 13.0 programı kullanılarak % 95'lik güven aralığında ve anlamlılık p

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Cite This Article

Kurtul, N., ÖZTÜRK, E., PEHLiVAN, S., PENÇE, S., GÜL, Ö., BALAT, Ö., CEBESOY, F. B., UĞUR, M. G. (2022). Serum total sialic acid levels and sialic acid acetyl esterase gene variation. Türk Jinekoloji ve Obstetrik Derneği Dergisi, Cilt: 9 - Sayı: 2, 99–105. https://ajindex.com/articles/631547

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