Journals / Türk Jinekoloji ve Obstetrik Derneği Dergisi / 2015 / Cilt: 12 - Sayı: 3

Efficacy of endocervical curettage and CA-125 measurement in endometrial serous carcinoma: A case series and literature review

Endometrial seröz karsinomda endoservikal küretajın ve CA-125 ölçümünün etkinliği: Olgu serisi ve literatür derlemesi

Pages
164–167
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Furthermore, pre-operative serum CA-125 levels may be important for management and counseling in the subgroup of women with ESC.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This is a case series and literature review of patients with endometrial serous carcinoma (ESC) in which endocervical curettage (ECC) and CA- 125 measurement were utilized as a diagnostic procedure in preoperative staging.
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Key Findings & Data:Materials and Methods: The patients were treated in the gynecologic oncology clinic of İstanbul University Faculty of Medicine between January 2005, and January 2015.
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Conclusion & Impact:Furthermore, pre-operative serum CA-125 levels may be important for management and counseling in the subgroup of women with ESC.
🔬Design:Review & Systematic Survey
📍Scope:2005 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: This is a case series and literature review of patients with endometrial serous carcinoma (ESC) in which endocervical curettage (ECC) and CA- 125 measurement were utilized as a diagnostic procedure in preoperative staging. Materials and Methods: The patients were treated in the gynecologic oncology clinic of İstanbul University Faculty of Medicine between January 2005, and January 2015. A total of 37 patients were included in the final analysis. Results: ECC accurately predicted ESC in 22 patients (59.5%). The mean pre-operative serum CA-125 level was 73.24±3.30 IU/mL; pre-operative serum CA-125 levels were elevated above 35 IU/mL in 25 patients (69%). Conclusion: ECC is an acceptable diagnostic tool to predict the presence or absence of cervical involvement in endometrial cancer. On the other hand, its accuracy in specific subgroups requires further analysis in carefully designed prospective studies. Furthermore, pre-operative serum CA-125 levels may be important for management and counseling in the subgroup of women with ESC.

Özet

Öz Amaç: Bu olgu serisi ve derlemede amaç endometrial seröz karsinom (ESK) hastalarında endoservikal küretajın (ESK) ve kanda CA-125 ölçümünün cerrahi yaklaşım öncesi uygulamalarında etkinliğini araştırmaktır. Gereç ve Yöntem: İstanbul Üniversitesi Tıp Fakültesi nin Jinekolojik Onkoloji Kliniği ne başvurmuş hastalar Ocak 2005 ve Ocak 2015 arası retrospektif olarak taranmış ve son çalışmaya 37 hasta dahil edilmiştir. Bulgular: Endometrial küretaj 22 hastada ESK tanısını koymuştur. Cerrahi yaklaşım öncesi kanda CA-125 seviyesi 73,24±3,30 IU/ml bulunmuştur. Yirmi beş hastanın, CA-125 seviyesi 35 IU/mL nin üzerinde çıkmıştır. Sonuç: Endometrial küretaj, endometrial kanserde servikal yayılmanın varlığının tanısında etkin bir araçtır. Öte yandan endometrial kanserlerin alt gruplarında etkinliğini ölçmede prospektif çalışmalara halen ihtiyaç vardır. Ek olarak, cerrahi yaklaşım öncesi kanda CA-125 ölçümü endometrial seröz karsinom hastalarının yönetiminde katkı sağlayabilir.

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Cite This Article

SÖZEN, H., BERKMAN, S., VATANSEVER, D., BAŞTU, E., İYİBOZKURT, A. C., TOPUZ, S., DOĞAN, M. (2022). Efficacy of endocervical curettage and CA-125 measurement in endometrial serous carcinoma: A case series and literature review. Türk Jinekoloji ve Obstetrik Derneği Dergisi, Cilt: 12 - Sayı: 3, 164–167. https://ajindex.com/articles/631447

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References (15)

  1. Gurpide E. Endometrial cancer: biochemical and clinical correlates. J Natl Cancer Inst 1991;83:405-16
  2. Christopherson WM, Alberhasky RC, Connelly PJ. Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma. Cancer 1982;49:1511-23
  3. Lauchlan SC. Tubal (serous) carcinoma of the endometrium. Arch Pathol Lab Med 1981;105:615-8
  4. Lauchlan SC. The secondary mullerian system revisited. Int J Gynecol Pathol 1994;13:73-9
  5. Fanning J, Evans MC, Peters AJ, Samuel M, Harmon ER, Bates JS. Endometrial adenocarcinoma histologic subtypes: clinical and pathologic profile. Gynecol Oncol 1989;32:288-91
  6. Hendrickson M, Ross J, Eifel P, Martinez A, Kempson R. Uterine papillary serous carcinoma: a highly malignant form of endometrial adenocarcinoma. Am J Surg Pathol 1982;6:93-108
  7. Walker AN, Mills SE. Serous papillary carcinoma of the endometrium. A clinicopathologic study of 11 cases. Diagn Gynecol Obstet 1982;4:261-7
  8. Frumovitz M, Slomovitz BM, Singh DK, Broaddus RR, Abrams J, Sun CC, et al. Frozen section analyses as predictors of lymphatic spread in patients with early-stage uterine cancer. J Am Coll Surg 2004;199:388-93
  9. Kietlinska Z, Stelmachow J, Antczak A, Timorek A, Sawicki W, Tyminska B. [Preoperative evaluation of cervical involvement in endometrial cancer]. Ginekol Pol 1998;69:247-51
  10. Leminen A, Forss M, Lehtovirta P. Endometrial adenocarcinoma with clinical evidence of cervical involvement: accuracy of diagnostic procedures, clinical course, and prognostic factors. Acta Obstet Gynecol Scand 1995;74:61-6
  11. Mannel RS, Berman ML, Walker JL, Manetta A, DiSaia PJ. Management of endometrial cancer with suspected cervical involvement. Obstet Gynecol 1990;75:1016-22
  12. Morimura Y, Soeda S, Hashimoto T, Takano Y, Ohwada M, Yamada H, et al. The value of pre-operative diagnostic procedures for cervical involvement in uterine corpus carcinoma. Fukushima J Med Sci 2000;46:1-11
  13. Pete I, Godeny M, Toth E, Rado J, Pete B, Pulay T. Prediction of cervical infiltration in Stage II endometrial cancer by different preoperative evaluation techniques (D&C, US, CT, MRI). Eur J Gynaecol Oncol 2003;24:517-22
  14. Rubin SC, Hoskins WJ, Saigo PE, Nori D, Mychalczak B, Chapman D, et al. Management of endometrial adenocarcinoma with cervical involvement. Gynecol Oncol 1992;45:294-8
  15. Niloff JM, Klug TL, Schaetzl E, Zurawski VR Jr, Knapp RC, Bast RC, Jr. Elevation of serum CA125 in carcinomas of the fallop