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Journals / Türk Jinekoloji ve Obstetrik Derneği Dergisi / 2014 / Cilt: 11 - Sayı: 3

Kontrollü ovaryan hiperstimülasyon ve in vitro fertilizasyon işlemi sırasında ovaryan hiperstimülasyon sendromunu önlemek için yapılan coasting tedavi stratejisini takiben olan serum E2 seviyesi değişikliği siklus sonuçlarını etkiler mi?

Does the serum E2 level change following coasting treatment strategy to prevent ovarian hyperstimulation syndrome impact cycle outcomes during controlled ovarian hyperstimulation and in vitro fertilization procedure?

Nafiye YILMAZ
Serkan KAHYAOĞLU
Yaprak ÜSTÜN ENGİN
Saynur YILMAZ
Ayşe Seval ERDİNÇ ÖZGÜ
Ömer Hamdi YUMUŞAK
Pages
159–164
Publication Date
2022-11-05
DOI
—
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J Turk Soc Obstet Gynecol 2014;3:159-64 Key Words: Ovarian hyperstimulation syndrome, coasting, cycle outcome, in vitro fertilization

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Ovarian hyperstimulation syndrome (OHSS) remains as a clinical problem for hyperresponder patients during controlled ovarian hyperstimulation and in vitro fertilization (COH-IVF) procedure.
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Key Findings & Data:Herein, we aimed to evaluate the COH-IVF outcomes in hyperresponder patients managed with coasting treatment strategy for OHSS prevention regarding the establishment of clinical pregnancy as an endpoint of the treatment cycle.
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Conclusion & Impact:J Turk Soc Obstet Gynecol 2014;3:159-64 Key Words: Ovarian hyperstimulation syndrome, coasting, cycle outcome, in vitro fertilization
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Ovarian hyperstimulation syndrome (OHSS) remains as a clinical problem for hyperresponder patients during controlled ovarian hyperstimulation and in vitro fertilization (COH-IVF) procedure. Herein, we aimed to evaluate the COH-IVF outcomes in hyperresponder patients managed with coasting treatment strategy for OHSS prevention regarding the establishment of clinical pregnancy as an endpoint of the treatment cycle. Materials and Methods: The medical records related to the COH-IVF outcome in 119 hyperresponder patients who have exhibited a serum estradiol level greater than or equal to 3000 pg/mL were evaluated. The study was conducted on a total of 119 patients, 98 of whom have been treated by coasting or coasting with GnRH antagonist co-treatment strategies, while the remaining 21 women (control group) have not been managed with coasting treatment. The COH and IVF-ET outcomes in the 119 patients were compared based on the coasting treatment situation. Results: Among the women who received coasting treatment, the number of patients demonstrating E2 level decrement and also E2 level decrement rate after coasting were similar between patients with and without clinical pregnancy. Total gonadotropin dose, 2PN number, embryo number, and fertilization rate were significantly higher in the patients with a clinical pregnancy. Conclusion: The coasting treatment is a clinically useful preventive strategy for OHSS avoidance. GnRH antagonist co-treatment decreases the duration of coasting although any detrimental or ameliorating impact of this effect on pregnancy rates have not been seen. The E2 level decrement or increment following coasting treatment seems not to be related to cycle outcomes. J Turk Soc Obstet Gynecol 2014;3:159-64 Key Words: Ovarian hyperstimulation syndrome, coasting, cycle outcome, in vitro fertilization

Özet

Amaç: Ovaryan hiperstimülasyon sendromu (OHSS), kontrollü ovaryan hiperstimülasyon (KOH) ve in vitro fertilizasyon (KOH-IVF) prosedür uygulamalarında halen klinik bir problem olarak yerini korumaktadır. Aşırı cevaplı hastalarda OHSS önleme stratejisi olarak coasting uygulanarak, KOH- IVF siklus sonuçları klinik gebelik oranları esas alınarak değerlendirildi. Gereç ve Yöntemler: Serum E2 seviyesi 3000 pg/ml ve üzeri olan 119 aşırı cevaplı hastanın KOH-IVF siklus sonuçları değerlendirildi. Toplam 119 hastanın 98ine coasting veya coasting ile beraber GnRH antagonist uygulanırken, coasting uygulaması yapılmayan 21 hasta da kontrol grubu olarak dahil edildi. Coasting uygulanan 119 hastanın KOH ve IVF-ET sonuçları karşılaştırıldı. Bulgular: Coasting sonrası klinik gebelik gerçekleşip gerçekleşmeyen hastalar arasında E2 düşüş seviyesi ve E2 seviyesi düşüş oranları benzer olarak izlendi. Klinik gebeliği olan hastalarda total gonadotropin dozu, 2PN sayısı, embryo sayısı ve fertilizasyon oranları anlamlı bir biçimde daha fazla olduğu saptandı. Sonuç: Coasting OHSS gelişimini engellemek için klinik olarak kullanılan faydalı bir önleme statejisidir. GnRH antagonist ile beraber kullanımı gebelik üzerine zararlı yada iyileştirici etkisi gözlenmeden, coasting uygulama süresini azaltmaktadır. Coasting uygulamasını takiben E2 oranlarındaki düşüş ve yükselişlerin siklus sonuçlarını etkilemediği gözlenmiştir. J Turk Soc Obstet Gynecol 2014;3:159-64 Anahtar Kelimeler: Ovaryan hiperstimülasyon sendromu, coasting, siklus sonuçları, in vitro fertilizasyon

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Cite This Article

YILMAZ, N., KAHYAOĞLU, S., ENGİN, Y. Ü., YILMAZ, S., ÖZGÜ, A. S. E., YUMUŞAK, Ö. H. (2022). Kontrollü ovaryan hiperstimülasyon ve in vitro fertilizasyon işlemi sırasında ovaryan hiperstimülasyon sendromunu önlemek için yapılan coasting tedavi stratejisini takiben olan serum E2 seviyesi değişikliği siklus sonuçlarını etkiler mi?. Türk Jinekoloji ve Obstetrik Derneği Dergisi, Cilt: 11 - Sayı: 3, 159–164. https://ajindex.com/articles/631469

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