SavedAdd your journal

Journals / Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi / 2017 / Cilt: 63 - Sayı: 3

Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis

Tunay SARPEL
İlke Coşkun BENLİDAYI
Neslihan GÖKÇEN
Pages
249–252
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Serum Mg level was not found to be correlated with either inflammatory biomarkers.Conclusion: Although serum Mg is associated with the radiological severity of knee OA, it is not associated with inflammatory biomarkers including ESR and CRP

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: In this study, we aimed to evaluate the relationship of serum magnesium (Mg) with the radiological severity and inflammation in the patients with knee osteoarthritis (OA).Patients and methods: A total of 75 patients (61 females, 14 males; mean age 67.5±9.9 years; range 44 to 92 years) with the Kellgren-Lawrence Grade 1-4 knee OA were included in the study.
📊
Key Findings & Data:Serum Mg levels (mg/dL) and inflammatory markers including erythrocyte sedimentation rate (ESR; mm/h) and C-reactive protein (CRP; mg/dL) were recorded.
💡
Conclusion & Impact:Serum Mg level was not found to be correlated with either inflammatory biomarkers.Conclusion: Although serum Mg is associated with the radiological severity of knee OA, it is not associated with inflammatory biomarkers including ESR and CRP
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: In this study, we aimed to evaluate the relationship of serum magnesium (Mg) with the radiological severity and inflammation in the patients with knee osteoarthritis (OA).Patients and methods: A total of 75 patients (61 females, 14 males; mean age 67.5±9.9 years; range 44 to 92 years) with the Kellgren-Lawrence Grade 1-4 knee OA were included in the study. Serum Mg levels (mg/dL) and inflammatory markers including erythrocyte sedimentation rate (ESR; mm/h) and C-reactive protein (CRP; mg/dL) were recorded. Serum Mg levels of the patients with mild OA and severe OA were compared. The correlation between Mg and both inflammatory markers was analyzed.Results: Severe OA group had significantly lower Mg levels than the mild OA group (p=0.044). Serum Mg level was not found to be correlated with either inflammatory biomarkers.Conclusion: Although serum Mg is associated with the radiological severity of knee OA, it is not associated with inflammatory biomarkers including ESR and CRP

🔖

Cite This Article

SARPEL, T., BENLİDAYI, İ. C., GÖKÇEN, N. (2022). Serum magnesium level is not associated with inflammation in patients with knee osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, Cilt: 63 - Sayı: 3, 249–252. https://ajindex.com/articles/628614

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Goggs R, Vaughan-Thomas A, Clegg PD, Carter SD, Innes JF, Mobasheri A, et al. Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr 2005;45:145-64
  2. Nielsen FH. Magnesium, inflammation, and obesity in chronic disease. Nutr Rev 2010;68:333-40
  3. Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, et al. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 2003;24:39-52
  4. Touyz RM. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med 2003;24:107-36
  5. Abbott RD, Ando F, Masaki KH, Tung KH, Rodriguez BL, Petrovitch H, et al. Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program). Am J Cardiol 2003;92:665-9
  6. Dai Q, Shrubsole MJ, Ness RM, Schlundt D, Cai Q, Smalley WE, et al. The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. Am J Clin Nutr 2007;86:743-51
  7. Leone N, Courbon D, Ducimetiere P, Zureik M. Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology 2006;17:308-14
  8. Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, et al. Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis. PLoS One 2015;10: 127666
  9. Zeng C, Wei J, Li H, Yang T, Zhang FJ, Pan D, et al. Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis. J Rheumatol 2015;42:1231-6
  10. Qin B, Shi X, Samai PS, Renner JB, Jordan JM, He K. Association of dietary magnesium intake with radiographic knee osteoarthritis: results from a population-based study. Arthritis Care Res (Hoboken) 2012;64:1306-11
  11. Hunter DJ, Hart D, Snieder H, Bettica P, Swaminathan R, Spector TD. Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins. Rheumatology (Oxford) 2003;42:1311-6
  12. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957;16:494-502
  13. Baker JF, Byrne DP, Walsh PM, Mulhall KJ. Human chondrocyte viability after treatment with local anesthetic and/or magnesium: results from an in vitro study. Arthroscopy 2011;27:213-7
  14. Feyerabend F, Witte F, Kammal M, Willumeit R. Unphysiologically high magnesium concentrations support chondrocyte proliferation and redifferentiation. Tissue Eng 2006;12:3545-56
  15. Vormann J, Förster C, Zippel U, Lozo E, Günther T, Mer