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Journals / Türkiye Diyabet ve Obezite Dergisi / 2021 / Cilt: 5 - Sayı: 2

Evaluation of α-klotho, FGF-23 and Insulin Resistance in Obese Prediabetics

Obez Prediyabetiklerde α-klotho, FGF-23 ve İnsülin Direncinin Değerlendirilmesi

Taner BAYRAKTAROĞLU
Çınar SEVERCAN
Ayşe Ceylan HAMAMCIOĞLU
Pages
131–136
Publication Date
2022-11-06
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Result: According to the findings, a significant increase was detected in serum LDL-C, TC, HbA1c, glucose, insulin and HOMA-IR levels in the obese prediabetic group compared to the control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Prediabetes is a condition with hyperglycemia and risk of development type 2 diabetes mellitus (T2DM).
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Key Findings & Data:The aim of this study is to determine the concentrations of blood pressure, serum lipoproteins, glucose and insulin levels as well as the concentrations of α-klotho and FGF-23 parameters.
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Conclusion & Impact:Result: According to the findings, a significant increase was detected in serum LDL-C, TC, HbA1c, glucose, insulin and HOMA-IR levels in the obese prediabetic group compared to the control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:prediyabet · insülin direnci · α-klotho

Abstract

Aim: Prediabetes is a condition with hyperglycemia and risk of development type 2 diabetes mellitus (T2DM). The aim of this study is to determine the concentrations of blood pressure, serum lipoproteins, glucose and insulin levels as well as the concentrations of α-klotho and FGF-23 parameters. We also aim at the correlation between all these parameters in obese prediabetics and obese normoglycemics. Material methods: A total of 26 obese normoglycemic (control group) and 25 obese prediabetic individuals were included in this study. Glucose, haemoglobin A1c (HbA1c) and cholesterols levels were analyzed as part of a routine procedure in the biochemistry laboratories of our hospital using an autoanalyzer. In order to determine α-klotho and fibroblast growth factor-23 (FGF-23) levels, ELISA method was used. Result: According to the findings, a significant increase was detected in serum LDL-C, TC, HbA1c, glucose, insulin and HOMA-IR levels in the obese prediabetic group compared to the control group (p

Özet

Amaç: Prediyabet, hiperglisemi ve tip 2 diabetes mellitus (T2DM) gelişme riski olan bir durumdur. Bu çalışmanın amacı, kan basıncı, serum lipoproteinleri, glikoz ve insülin düzeylerinin yanı sıra α-klotho ve FGF-23 parametrelerinin konsantrasyonlarını belirlemektir. Ayrıca obez prediyabetiklerde ve obez normoglisemilerde tüm bu parametreler arasındaki korelasyonu belirlemeyi hedefliyoruz. Gereç yöntemler: Toplam 26 obez normoglisemik (kontrol grubu) ve 25 obez prediyabetik birey bu çalışmaya dahil edildi. Hastanemizin biyokimya laboratuvarlarında rutin prosedür kapsamında glukoz, hemoglobin A1c (HbA1c) ve kolesterol seviyeleri otoanalizör kullanılarak analiz edildi. α-klotho ve fibroblast büyüme faktörü-23 (FGF-23) düzeylerini belirlemek için ELISA yöntemi kullanıldı. Bulgular: Bulgulara göre obez prediyabetik grupta serum LDL-C, TC, HbA1c, glikoz, insülin ve HOMA-IR seviyelerinde kontrol grubuna göre anlamlı artış tespit edildi (p

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Cite This Article

BAYRAKTAROĞLU, T., SEVERCAN, Ç., HAMAMCIOĞLU, A. C. (2022). Evaluation of α-klotho, FGF-23 and Insulin Resistance in Obese Prediabetics. Türkiye Diyabet ve Obezite Dergisi, Cilt: 5 - Sayı: 2, 131–136. https://ajindex.com/articles/627877

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