SavedAdd your journal

Journals / Türkiye Diyabet ve Obezite Dergisi / 2021 / Cilt: 5 - Sayı: 3

Vitamin D Deficiency and Microalbuminuria in Patients with Diabetes Mellitus

Diabetes Mellituslu Hastalarda Mikroalbuminüri ve D Vitamini

Yalçın HACIOĞLU
Savaş KARATAŞ
Şennur KÖSE
Pages
265–269
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Median GFR was 98 (38-136) ml/dk and median 25 (OH) D level was 17.1 (5.0- 44.2)mg/dl. 25 (OH) Vitamin D levels and GFR were found to be significantly lower in the microalbuminuria group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: As diabetes mellitus and its complications become more prevalent in the world, it is becoming an important public health problem.
📊
Key Findings & Data:Material and Methods: 52 type 1 (20.1%) and 206 (79.9%) type 2 diabetes patients who applied to the outpatient Endocrinology and Metabolic Diseases clinic between April 2019 and December 2020 were included in the study.
💡
Conclusion & Impact:Median GFR was 98 (38-136) ml/dk and median 25 (OH) D level was 17.1 (5.0- 44.2)mg/dl. 25 (OH) Vitamin D levels and GFR were found to be significantly lower in the microalbuminuria group (p
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:diyabet · mikroalbuminüri · d vitamini

Abstract

Aim: As diabetes mellitus and its complications become more prevalent in the world, it is becoming an important public health problem. Previous studies have investigated vitamin D in the context of diabetes mellitus and its complications.. Microalbuminuria is important as the initial level of diabetic nephropathy. In this context, we aimed to investigate the level and deficiency of vitamin D in diabetic patients with microalbuminuria. Material and Methods: 52 type 1 (20.1%) and 206 (79.9%) type 2 diabetes patients who applied to the outpatient Endocrinology and Metabolic Diseases clinic between April 2019 and December 2020 were included in the study. Patients were classified according to microalbuminuria. Fasting glucose, HbA1c, duration of diabetes, and 25 (OH) Vitamin D levels and mean waist circumference were compared between the groups. Finally, the groups were compared according to diabetes type and microalbuminuria. Results: Urinary albumin/creatinine rates (UAC) in 159 (42.7%) diabetic patients were in normal range, and 65 (17.5%) diabetics had UAC between 30-300 mcg. 12 (3.2%) had UAC >300 mcg. 22 (5.9%) had chronic renal failure. Vitamin D deficiency was 61.6% and vitamin D insufficiency was 28.6% in all study groups. Median GFR was 98 (38-136) ml/dk and median 25 (OH) D level was 17.1 (5.0- 44.2)mg/dl. 25 (OH) Vitamin D levels and GFR were found to be significantly lower in the microalbuminuria group (p

Özet

Amaç: Dünyada giderek artan sıklığı ile diyabet, komplikasyonları yolu ile önemli bir halk sağlığı sorunu olarak karşımıza çıkmaktadır. Önceki çalışmalar vitamin D için hem diyabet hem de komplikasyonları ile ilişkili olarak değerlendirmiştir. Mikroalbuminüri diyabetik nefropatinin başlangıç düzeyi olarak önem arz etmektedir. Bu bağlamda mikroalbuminürisi olan diyabetik hastalarda D vitamini düzeyini ve eksikliğini araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmaya Nisan 2019 ve Aralık 2020 tarihleri arasında Endokrinoloji ve Metabolizma Hastalıkları polikliniğine başvuran 52 tip 1 (%20,1) ve 206 (%79,9) tip 2 diyabet hastası dahil edildi. Hastalar mikroalbüminüriye göre sınıflandırıldı. Açlık glikozu, HbA1c, diyabet süresi, 25 (OH) Vitamin D düzeyleri ve ortalama bel çevresi gruplar arasında karşılaştırıldı. Son olarak gruplar diyabet tipi ve mikroalbüminüriye göre karşılaştırıldı. Bulgular: 159 (%42,7) hastada normal idrar albümin / kreatinin oranı (UAC) vardı. 65 (%17,5) hastada 30-300 mcg arasında UAC vardı. 12 (%3,2) UAC> 300 mcg'ye sahipti. 22'sinde (%5,9) kronik böbrek yetmezliği vardı. Tüm çalışma gruplarında D vitamini eksikliği %61,6, D vitamini yetmezliği %28.6 olarak bulundu. Mikroalbüminüri grubunda ortanca GFR 98 (38-136) ml/dk)idi ve ortanca 25 (OH) D düzeyi 17.1 (5,0-44,2)mg/dl idi. GFR ve 25 (OH) D düzeyleri anlamlı olarak düşük bulundu (p

🔖

Cite This Article

HACIOĞLU, Y., KARATAŞ, S., KÖSE, Ş. (2022). Vitamin D Deficiency and Microalbuminuria in Patients with Diabetes Mellitus. Türkiye Diyabet ve Obezite Dergisi, Cilt: 5 - Sayı: 3, 265–269. https://ajindex.com/articles/627850

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Association, A. D. (2021)
  2. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes—2021. Diabetes Care, 44(Supplement 1), S151–S167.
  3. Svensson MK, Cederholm J, Eliasson B, Zethelius B, Gudbjörnsdottir S, Register SND. Albuminuria and renal function as predictors of cardiovascular events and mortality in a general population of patients with type 2 diabetes: a nationwide observational study from the Swedish National Diabetes Register. Diab Vasc Dis Res. 2013;10(6):520–529. doi:10.1177/1479164113500798
  4. Yuyun MF, Dinneen SF, Edwards OM, Wood E, Wareham NJ. Absolute level and rate of change of albuminuria over 1 year independently predict mortality and cardiovascular events in patients with diabetic nephropathy. Diabet Med. 2003;20(4):277–282. doi:10.1046/j.1464-5491.2003.00940.x
  5. Briet, C., Piffaretti, C., Fosse, S., Denis, P., Allix, I., Campagna, A. F., & Coutant, R. (2018). [Epidemiology of type 1 diabetes and its complications]. La Revue Du Praticien, 68(6), 607–610
  6. Sana, M. A., Chaudhry, M., Malik, A., Iqbal, N., Zakiuddin, A., & Abdullah, M. (2020). Prevalence of Microalbuminuria in Type 2 Diabetes Mellitus. Cureus, 12(12), e12318.
  7. Asadujjaman, M., Kashem, A., Chowdhury, A. A., Roy, A. S., Muqueet, M. A., Fazilatunnasa, M., Ahammed, S. U., Rabbani, M. G., Rahman, M. A., Kabir, M. S., Hossain, M. B., Islam, M. S., Das, S. K., Khan, E. H., Borman, G. C., & Khatun, N. (2018). Prevalence of Microalbuminuria and Overt Proteinuria İn Diabetes Mellitus and their Association with Renal Function. Mymensingh Medical Journal: MMJ, 27(3),467–474
  8. Wimalawansa, S.J. (2016) Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. J. Steroid Biochem. Mol.Biol. pii: S0960-0760(16)30253-9. doi:10.1016/j.jsbmb.2016.09.017 8. Gulseth HL,Wium C, Angel K, Eriksen EF, Birkeland KI. Effects of vitamin D supplementation on insulin sensitivity and insulin secretion in subjects with type 2 diabetes and vitamin D deficiency:a randomized controlled trial. Diabetes Care. 2017;40(7):872–8 9. Nazarian S, St Peter JV, Boston RC, Jones SA, Mariash CN. Vitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucose. Transl Res. 2011 Nov;158(5):276–81 10. Kuhlmann, A., Haas, C. S., Gross, M.-L., Reulbach, U., Holzinger, M., Schwarz, U., Ritz, E., & Amann, K.(2004). 1,25-Dihydroxyvitamin D3 d