Journals / Türkiye Diyabet ve Obezite Dergisi / 2022 / Cilt: 6 - Sayı: 1

Evaluation of Insulin Resistance Measurement Methods in Patients with Polycystic Ovary Syndrome

Polikistik Over Sendromlu Hastalarda İnsülin Direnci Ölçüm Metodlarının Değerlendirilmesi

Pages
24–31
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The TyG index can be used as an alternative method in evaluating insulin resistance among these patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: This study aims to compare insulin resistance (IR) measurement methods in women with and without polycystic ovary syndrome (PCOS) who have the same body mass index.
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Key Findings & Data:Material and Methods: There were 84 women with PCOS and non-PCOS (n=18 normal weight and n=24 overweight/obese in both groups).
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Conclusion & Impact:The TyG index can be used as an alternative method in evaluating insulin resistance among these patients.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Polikistik over sendromu · İnsülin direnci · TyG

Abstract

Aim: This study aims to compare insulin resistance (IR) measurement methods in women with and without polycystic ovary syndrome (PCOS) who have the same body mass index. Material and Methods: There were 84 women with PCOS and non-PCOS (n=18 normal weight and n=24 overweight/obese in both groups). Triglyceride glucose index (TyG), assessment of insulin resistance with homeostasis model (HOMA-IR), visceral adiposity index (VAI) were calculated using lipid level, glucose level and anthropometric measurements. Mann-Whitney U or Student's t-test was used to compare measurements between the groups. The relationship between HOMA-IR and age was calculated with the Pearson correlation test, and the relationship between HOMA-IR and TyG was calculated with the Spearman correlation test. p3.91 (89.5% sensitivity, 76.9% specificity) predicted insulin resistance (IR). Conclusion: TyG and HOMA-IR levels are higher in women with PCOS than non-PCOS. The TyG index can be used as an alternative method in evaluating insulin resistance among these patients.

Özet

Amaç: Bu çalışmada polikistik over sendromlu (PKOS) kadınlarda insülin direnci (IR) ölçüm metodlarının, aynı beden kütle indeksine sahip PKOS olmayan kadınlarla karşılaştırılması hedeflenmiştir. Gereç ve Yöntemler: Çalışmamıza PKOS (n=18 normal kilolu ve n=24 hafif kilolu/obez) ve PKOS olmayan (n=18 normal kilolu ve n=24 hafif kilolu/obez) toplam 84 kadın dahil edildi. Lipit düzeyi, glukoz düzeyi ve antropometrik ölçümler kullanılarak trigliserid glukoz indeksi (TyG), insülin direncinin homeostaz modeliyle değerlendirmesi (HOMA-IR), visseral adipozite indeksi (VAI) hesaplandı. PKOS olan ve olmayan gruplar arasında ölçüm değerlerinin karşılaştırılmasında Mann-Whitney U test ya da Student t-test kullanıldı. HOMAIR ile yaş arasındaki ilişki Pearson korelasyon testi, HOMA-IR ile TyG arasındaki ilişki Spearman korelasyon testi ile hesaplandı. p3.91 olması (%89.5 sensivite, %76.9 spesifite) insulin rezistansını (IR) predikte etti. Sonuç: PKOS’lu kadınlarda PKOS olmayanlara göre TyG ve HOMA-IR düzeyleri yüksektir. Bu hastalarda insulin rezistansı değerlendirilmesinde TyG indeksi alternatif bir metod olarak kullanılabilir

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Cite This Article

BiLGiNER, M. C., NUHOĞLU, İ., KOÇAK, M., ÜÇÜNCÜ, Ö., TÜFEKÇİ, D., GÜNAY, Y. E., USTA, O., COŞKUN, H. (2022). Evaluation of Insulin Resistance Measurement Methods in Patients with Polycystic Ovary Syndrome. Türkiye Diyabet ve Obezite Dergisi, Cilt: 6 - Sayı: 1, 24–31. https://ajindex.com/articles/626786

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References (1)

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