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Journals / Türk Geriatri Dergisi / 2011 / Cilt: 14 - Sayı: 1

Postmenapozal sağlıklı kadınlarda kombine hormon tedavisi ve tibolon'un glukoz ve lipid metabolizmasına etkisi

The effect of hormone therapy and tibolone on glucose and lipid metabolism in healthy postmenopausal women

Esen AKBAY
Ramazan GEN
Saffet DİLEK
Filiz ÇAYAN
Umut DİLEK
Pages
19–25
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Before and after 12 weeks of treatment, glucose metabolism, insulin resistance (HOMA-IR) and lipid metabolism parameters were compared.Results: CEE/MPA treatment significantly decreased fasting glucose levels, fasting insulin levels, 2 h glucose levels, 2 h insulin levels, and HOMA-IR and LDL levels while increasing triglyceride and HDL levels (p

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Objective & Hypothesis:Introduction: To evaluate the effects of tibolone and conventional hormone therapy on insulin sensitivity and lipid metabolism in healthy postmenopausal women.Materials and Method: The study included 85 normoinsulinemic healthy postmenopausal Turkish women.
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Key Findings & Data:The participants were assigned to one of three groups: 26 women received 0.625 mg of CEE+ MPA daily, 32 received 2.5 mg of tibolone daily, and 27 had no treatment and served as a control group.
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Conclusion & Impact:Before and after 12 weeks of treatment, glucose metabolism, insulin resistance (HOMA-IR) and lipid metabolism parameters were compared.Results: CEE/MPA treatment significantly decreased fasting glucose levels, fasting insulin levels, 2 h glucose levels, 2 h insulin levels, and HOMA-IR and LDL levels while increasing triglyceride and HDL levels (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: To evaluate the effects of tibolone and conventional hormone therapy on insulin sensitivity and lipid metabolism in healthy postmenopausal women.Materials and Method: The study included 85 normoinsulinemic healthy postmenopausal Turkish women. The participants were assigned to one of three groups: 26 women received 0.625 mg of CEE+ MPA daily, 32 received 2.5 mg of tibolone daily, and 27 had no treatment and served as a control group. Before and after 12 weeks of treatment, glucose metabolism, insulin resistance (HOMA-IR) and lipid metabolism parameters were compared.Results: CEE/MPA treatment significantly decreased fasting glucose levels, fasting insulin levels, 2 h glucose levels, 2 h insulin levels, and HOMA-IR and LDL levels while increasing triglyceride and HDL levels (p

Özet

Giriş: Menapozla birlikte gelişen insülin direncinde artma ve lipid metabolizmasında kötüleşme, metabolik sendromun komponentleridir. Hormon tedavisi almayan kadınlarda, bu süreçin hızlandığı bilinmektedir. Bu çalışmada postmenapozal dönemde sık kullanılan oral östrojen ve progesteron kombine hormon preparatı ile tibolon tedavisinin glukoz intoleransı ve lipid metabolizması üzerine olan etkisinin araştırılması.Gereç ve Yöntem: 85 normoglisemik sağlıklı postmenopozal hasta randomize olarak 3 gruba ayrıldı. Grup 1'e (n=26) konjuge equine östrojen (CEE) + medroksiprogesteron asetat (MPA), Grup 2'ye (n=32) ise tibolon tedavisi başlandı. Grup 3 (n=27) ise kontrol grubu olarak belirlendi ve hiçbir tedavi verilmedi. Hastaların tedavi öncesi ve 12. haftada karbonhidrat metabolizması, insülin direnci (homeostaz modeli-HOMA-IR ) ve lipid parametreleri karşılaştırıldı.Bulgular: CEE/MPA tedavisinin, açlık glukoz ve insülin, postgrandial 2. saat glukoz ve insülin, HOMA- IR, total kolesterol ve LDL değerlerini istatiksel anlamlı derecede azaltığı, ancak trigliserid ve HDL değerlerini artırdığı görüldü (p

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Cite This Article

AKBAY, E., GEN, R., DİLEK, S., ÇAYAN, F., DİLEK, U. (2022). Postmenapozal sağlıklı kadınlarda kombine hormon tedavisi ve tibolon'un glukoz ve lipid metabolizmasına etkisi. Türk Geriatri Dergisi, Cilt: 14 - Sayı: 1, 19–25. https://ajindex.com/articles/624059

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References (14)

  1. Proudler AJ, Felton CV, Stevenson JC. Ageing and the response of plasma insulin, glucose, and C-peptide concentrations to intravenous glucose in postmenopausal women. Clin Sci 1992; 83:489–94
  2. Walton C, Godsland IF, Proudler AJ, Wynn V, Stevenson JC. The effects of the menopause on insulin sensitivity, secretion, and elimination in nonobese, healthy women. Eur J Clin Invest 1993;23:466–73
  3. Stevenson JC, Crook DC, Godsland IF. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis 1993;98:83–90
  4. Ley CJ, Lees B, Stevenson JC. Sex and menopause-associated changes in body fat distribution. Am J Clin Nutr 1992;55: 950–4
  5. Otsuki M, Kasayama S, Morita S, et al. Menopause, but not age, is an independent risk factor for fasting plasma glucose levels in nondiabetic women. Menopause 2007;14:404–7
  6. Kahn SE, Prigeon RL, Schwartz RS, et al. Obesity, body fat distribution, insulin sensitivity and islet-cell function as explanations for metabolic diversity. J Nutr 2001;131:354–60
  7. Ryan AS, Nicklas BJ, Berman DM. Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women. Diabetes Care 2002;25(1):127-33
  8. Soranna L, Cucinelli F, Perri C, Muzj G, Giuliani M, Villa P, Lanzone A. Individual effect of E2 and dydrogesterone on insulin sensitivity in post-menopausal women. J Endocrinol Invest 2002;25(6):547-50
  9. Munoz J, Derstine A, Gower BA. Fat distribution and insulin sensitivity in postmenopausal women: influence of hormone replacement. Obes Resm 2002;10(6):424-31
  10. Manassiev NA, Godsland IF, Crook D, Proudler AJ, Whitehead MI, Stevenson JC. Effect of postmenopausal oestradiol and dydrogesterone therapy on lipoproteins and insulin sensitivity, secretion and elimination in hysterectomised women. Maturitas 2002;42(3):233-42
  11. Lobo RA. Effects of hormonal replacement on lipids and lipoproteins in postmenopausal women. Clin Endocrinol 1991;73: 925–30
  12. Odmark IS, Carlström K, Jonsson B, Jonasson AF. Conjugated estrogen/progestagen versus tibolone hormone replacement therapy in postmenopausal women: Effects on carbohydrate metabolism and serum sex hormone-binding globulin. Maturitas 2006;53:89-96
  13. Morin-Papunen LC, Vauhkonen I, Roukonen A, Tapanainen JS, Raudaskoski T. Effects of tibolone and cyclic therapy on glucose metabolism in non-diabetic obese postmenopausal women: a randomized study. Eur J Endocrinol 2004;150:705-14
  14. Matthews DR, Hosker JP, Rudenski AS