Journals / Türk Geriatri Dergisi / 2014 / Cilt: 17 - Sayı: 2

GERİATRİK HASTADA AÇIK KALP AMELİYATI SIRASINDA VE SONRASINDA, PROPOFOLÜN DÜŞÜK İNFÜZYON DOZUNDA VERİLMESİNE RAĞMEN GELİŞEN PROPOFOL İNFÜZYON SENDROMU

PROPOFOL-RELATED INFUSION SYNDROME INA GERIATRIC PATIENT FOLLOWING THE USEOF PROPOFOL IN LOW DOSES AND SHORTDURATION, DURING AND AFTER CARDIACSURGERY

Pages
196–199
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The patient developed severe lactic acidosis, oliguria and bradycardia requiring cardiac pacing in the 6th hour postoperatively.Lactic acidosis and clinical condition improved promptly within a few hours, following the discontinuation of propofol infusion

📌 3 Key Takeaways

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Objective & Hypothesis:Propofol, is a potent short-acting intravenous sedative-hypnotic agent used for induction andmaintainance of general anesthesia and to provide continuous sedation in the intensive careunit.
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Key Findings & Data:Hereby we present a case of PRIS which developed in a geriatric patient (74y), following coronary artery by-pass grafting and aortic valvereplacement surgery in the early postoperative period.
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Conclusion & Impact:The patient developed severe lactic acidosis, oliguria and bradycardia requiring cardiac pacing in the 6th hour postoperatively.Lactic acidosis and clinical condition improved promptly within a few hours, following the discontinuation of propofol infusion
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Propofol, is a potent short-acting intravenous sedative-hypnotic agent used for induction andmaintainance of general anesthesia and to provide continuous sedation in the intensive careunit. Propofol-related infusion syndrome (PRIS) is a rare yet often fatal syndrome associated withthe continuous infusion of propofol. It is characterized by severe metabolic acidosis, cardiac failure, bradycardia, myoglobinuria and renal failure. Hereby we present a case of PRIS which developed in a geriatric patient (74y), following coronary artery by-pass grafting and aortic valvereplacement surgery in the early postoperative period. Propofol was used in low doses both intraoperatively and in the intensive care unit (ICU) postoperatively. The patient developed severe lactic acidosis, oliguria and bradycardia requiring cardiac pacing in the 6th hour postoperatively.Lactic acidosis and clinical condition improved promptly within a few hours, following the discontinuation of propofol infusion

Özet

Propofol, genel anestezi indüksiyonunda ve idamesinde, ayrıca yoğun bakımda sedasyonamacıyla kullanılan, kısa etkili potent bir hipnotik-sedatif ajandır. Propofol infüzyon sendromu,propofolün devamlı infüzyonuna bağlı gelişebilen, ender, ancak sıklıkla ölümle sonuçlanabilen birdurumdur. Ağır metabolik asidoz, kalp yetersizliği, bradikardi, miyoglobinüri ve böbrek yetersizliğiile karakterizedir. Bu makalede, koroner arter bypass greftleme ve aort kapağı replasmanı uygulanan geriatrik (74y) bir hastada postoperative erken dönemde gelişen propofol infüzyon sendromu bildirilmektedir. Hem anestezi sırasında, hem de postoperatif yoğun bakım sedasyonusırasında düşük doz propofol uygulanan hastada, postoperative altıncı saatte ağır laktik asidoz,oligüri ve pacemaker gerektiren bradikardi gelişti. Propofol kesildikten sonra laktik asidoz ve hastanın genel durumunda bir kaç saat içinde hızlı bir düzelme kaydedildi

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Cite This Article

ÖZCEM, B., DEREN, S., YAYCI, F. (2022). GERİATRİK HASTADA AÇIK KALP AMELİYATI SIRASINDA VE SONRASINDA, PROPOFOLÜN DÜŞÜK İNFÜZYON DOZUNDA VERİLMESİNE RAĞMEN GELİŞEN PROPOFOL İNFÜZYON SENDROMU. Türk Geriatri Dergisi, Cilt: 17 - Sayı: 2, 196–199. https://ajindex.com/articles/623906

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