Journals / Türk Geriatri Dergisi / 2014 / Cilt: 17 - Sayı: 1

GERİATRİK HASTADA AÇIK KALP AMELİYATI SIRASINDA VE SONRASINDA, PROPOFOLÜN DÜŞÜK İNFÜZYON DOZUNDA VERİLMESİNE RAĞMEN GELİŞEN PROPOFOL İNFÜZYON SENDROMU

PROPOFOL-RELATED INFUSION SYNDROME IN A GERIATRIC PATIENT FOLLOWING THE USE OF PROPOFOL IN LOW DOSES AND SHORT DURATION, DURING AND AFTER CARDIAC SURGERY: A CASE REPORT

Pages
108–111
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Lactic acidosis and clinical condition improved promptly within a few hours,following the discontinuation of propofol infusion

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Propofol, is a potent short-acting intravenous sedative-hypnotic agent used for induction andmaintenance of general anesthesia and to provide continuous sedation in the intensive careunit.
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Key Findings & Data:Hereby we present a case of propofol-related infusion syndrome which developed in 74 years of age patient, following coronary artery by-passgrafting and aortic valve replacement surgery in the early postoperative period.
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Conclusion & Impact:Lactic acidosis and clinical condition improved promptly within a few hours,following the discontinuation of propofol infusion
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Propofol, is a potent short-acting intravenous sedative-hypnotic agent used for induction andmaintenance of general anesthesia and to provide continuous sedation in the intensive careunit. Propofol-related infusion syndrome is a rare yet often fatal syndrome associated with thecontinuous infusion of propofol. It is characterized by severe metabolic acidosis, cardiac failure,bradycardia, myoglobinuria and renal failure. Hereby we present a case of propofol-related infusion syndrome which developed in 74 years of age patient, following coronary artery by-passgrafting and aortic valve replacement surgery in the early postoperative period. Low dose propofol was used both intraoperatively and in the intensive care unit postoperatively. The patientdeveloped severe lactic acidosis, oliguria and bradycardia requiring cardiac pacing in the sixthhour postoperatively. Lactic acidosis and clinical condition improved promptly within a few hours,following the discontinuation of propofol infusion

Özet

Propofol, genel anestezi indüksiyonunda ve idamesinde, ayrıca yoğun bakımda sedasyonamacıyla kullanılan, kısa etkili potent bir hipnotik-sedatif ajandır. Propofol infüzyon sendromu,propofolün devamlı infüzyonuna bağlı gelişebilen, ender, ancak sıklıkla ölümle sonuçlanabilen birdurumdur. Ağır metabolik asidoz, kalp yetersizliği, bradikardi, miyoglobinüri ve böbrek yetersizliğiile karakterizedir. Bu makalede, koroner arter bypass greftleme ve aort kapağı replasmanı uygulanan 74 yaşında bir hastada postoperative erken dönemde gelişen propofol infüzyon sendromubildirilmektedir. Hastaya anestezi sırasında ve postoperatif yoğun bakım sedasyonu sırasındadüşük doz propofol uygulandı. Hastada, postoperative altıncı saatte ağır laktik asidoz, oligüri vepacemaker gerektiren bradikardi gelişti. Propofol kesildikten sonra laktik asidoz ve hastanın geneldurumunda bir kaç saat içinde hızlı bir düzelme kaydedildi

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Cite This Article

ÖZCEM, B., DEREN, S., YAYCI, F. (2022). GERİATRİK HASTADA AÇIK KALP AMELİYATI SIRASINDA VE SONRASINDA, PROPOFOLÜN DÜŞÜK İNFÜZYON DOZUNDA VERİLMESİNE RAĞMEN GELİŞEN PROPOFOL İNFÜZYON SENDROMU. Türk Geriatri Dergisi, Cilt: 17 - Sayı: 1, 108–111. https://ajindex.com/articles/623861

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