The aim of this study was to evaluate the effects of unfractionated heparin therapy in an older population and to determine whether there was any difference from a younger population in terms of the activated partial thromboplastin time results and complication rates when using a standard nomogram.Materials and Methods: A total of 120 patients aged
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Introduction: In elderly patients, the dosing of unfractionated heparin is difficult because of changing metabolism, which affects the determination of a therapeutic level.
📊
Key Findings & Data:Introduction: In elderly patients, the dosing of unfractionated heparin is difficult because of changing metabolism, which affects the determination of a therapeutic level.
💡
Conclusion & Impact:The aim of this study was to evaluate the effects of unfractionated heparin therapy in an older population and to determine whether there was any difference from a younger population in terms of the activated partial thromboplastin time results and complication rates when using a standard nomogram.Materials and Methods: A total of 120 patients aged
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Introduction: In elderly patients, the dosing of unfractionated heparin is difficult because of changing metabolism, which affects the determination of a therapeutic level. The aim of this study was to evaluate the effects of unfractionated heparin therapy in an older population and to determine whether there was any difference from a younger population in terms of the activated partial thromboplastin time results and complication rates when using a standard nomogram.Materials and Methods: A total of 120 patients aged
🔖
Cite This Article
MÜDERRİSOĞLU, İ. H., ACIBUCA, A. (2022). THE OUTCOMES OF USING FIXED-DOSENOMOGRAM-GUIDED UNFRACTIONATEDHEPARIN THERAPY IN ELDERLY PATIENTS INCOMPARISON WITH YOUNGER PATIENTS. Türk Geriatri Dergisi, Cilt: 23 - Sayı: 3, 308–316. https://ajindex.com/articles/623592
Hylek EM, Regan S, Henault LE, et al. Challenges to the effective use of unfractionated heparin in the hospitalized management of acute thrombosis. Arch Intern Med 2003;163:621-7. (PMID:12622610
Aymanns C, Keller F, Maus S, et al. Review on pharmacokinetics and pharmacodynamics and the aging kidney. Clin J Am Soc Nephrol 2010;5(2):314– 27. (PMID:20056753
Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 2004;57(1):6–14. (PMID:14678335
Hirsh J, Bauer KA, Donati MB, et al. Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133(6):141–59. (PMID:18574264
Campbell NR, Hull RD, Brant R, et al. Aging and heparin-related bleeding. Arch Intern Med 1996;156(8):857–60. (PMID: 8774204
Schulman S, Beyth RJ, Kearon C, et al. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133(6 Suppl):257–98. (PMID:18574268
Cossette B, Pelletier ME, Carrier N, et al. Evaluation of bleeding risk in patients exposed to therapeutic unfractionated or low-molecular-weight heparin: a cohort study in the context of a quality improvement initiative. Ann Pharmacother 2010;44(6):994-1002. (PMID:20442353
Bauer SR, Ou NN, Dreesman BJ, et al. Effect of body mass index on bleeding frequency and acti-vated partial thromboplastin time in weight-based dosing of unfractionated heparin: a retrospective cohort study. Mayo Clin Proc 2009;84(12):1073-8. (PMID:19955244
Thomas MP, Mahaffey KW, Chiswell K, et al. Activated partial thromboplastin time measurement is not associated with clinical outcomes in patients with high-risk non-ST-segment elevation acute coronary syndromes treated with unfractionated heparin. J Thromb Thrombolysis 2012;34(1):114-9. (PMID:22323092
Floroff CK, Palm NM, Steinberg DH, et al. Higher maximum doses and infusion rates compared with standard unfractionated heparin therapy are associated with adequate anticoagulation without increased bleeding in both obese and non-obese patients with cardiovascular indications. Pharmacotherapy 2017;37(4):393-400. (PMID:28107569
Holbrook A, Schulman S, Witt DM, et al. Evidencebased management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College