Dergiler / Türk Geriatri Dergisi / 2020 / Cilt: 23 - Sayı: 3

THE OUTCOMES OF USING FIXED-DOSENOMOGRAM-GUIDED UNFRACTIONATEDHEPARIN THERAPY IN ELDERLY PATIENTS INCOMPARISON WITH YOUNGER PATIENTS

Sayfa
308–316
Yayın Tarihi
2022-11-05
DOI
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The aim of this study was to evaluate the effects of unfractionated heparin therapy in an older population and to determine whether there was any difference from a younger population in terms of the activated partial thromboplastin time results and complication rates when using a standard nomogram.Materials and Methods: A total of 120 patients aged

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Amaç & Hipotez:Introduction: In elderly patients, the dosing of unfractionated heparin is difficult because of changing metabolism, which affects the determination of a therapeutic level.
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Temel Bulgular & Veri:Introduction: In elderly patients, the dosing of unfractionated heparin is difficult because of changing metabolism, which affects the determination of a therapeutic level.
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Sonuç & Katkı:The aim of this study was to evaluate the effects of unfractionated heparin therapy in an older population and to determine whether there was any difference from a younger population in terms of the activated partial thromboplastin time results and complication rates when using a standard nomogram.Materials and Methods: A total of 120 patients aged
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Introduction: In elderly patients, the dosing of unfractionated heparin is difficult because of changing metabolism, which affects the determination of a therapeutic level. The aim of this study was to evaluate the effects of unfractionated heparin therapy in an older population and to determine whether there was any difference from a younger population in terms of the activated partial thromboplastin time results and complication rates when using a standard nomogram.Materials and Methods: A total of 120 patients aged

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Bu Makaleye Atıf Yap

MÜDERRİSOĞLU, İ. H., ACIBUCA, A. (2022). THE OUTCOMES OF USING FIXED-DOSENOMOGRAM-GUIDED UNFRACTIONATEDHEPARIN THERAPY IN ELDERLY PATIENTS INCOMPARISON WITH YOUNGER PATIENTS. Türk Geriatri Dergisi, Cilt: 23 - Sayı: 3, 308–316. https://ajindex.com/articles/623592

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Kaynakça (11)

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  2. Aymanns C, Keller F, Maus S, et al. Review on pharmacokinetics and pharmacodynamics and the aging kidney. Clin J Am Soc Nephrol 2010;5(2):314– 27. (PMID:20056753
  3. Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 2004;57(1):6–14. (PMID:14678335
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  5. Campbell NR, Hull RD, Brant R, et al. Aging and heparin-related bleeding. Arch Intern Med 1996;156(8):857–60. (PMID: 8774204
  6. Schulman S, Beyth RJ, Kearon C, et al. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133(6 Suppl):257–98. (PMID:18574268
  7. Cossette B, Pelletier ME, Carrier N, et al. Evaluation of bleeding risk in patients exposed to therapeutic unfractionated or low-molecular-weight heparin: a cohort study in the context of a quality improvement initiative. Ann Pharmacother 2010;44(6):994-1002. (PMID:20442353
  8. Bauer SR, Ou NN, Dreesman BJ, et al. Effect of body mass index on bleeding frequency and acti-vated partial thromboplastin time in weight-based dosing of unfractionated heparin: a retrospective cohort study. Mayo Clin Proc 2009;84(12):1073-8. (PMID:19955244
  9. Thomas MP, Mahaffey KW, Chiswell K, et al. Activated partial thromboplastin time measurement is not associated with clinical outcomes in patients with high-risk non-ST-segment elevation acute coronary syndromes treated with unfractionated heparin. J Thromb Thrombolysis 2012;34(1):114-9. (PMID:22323092
  10. Floroff CK, Palm NM, Steinberg DH, et al. Higher maximum doses and infusion rates compared with standard unfractionated heparin therapy are associated with adequate anticoagulation without increased bleeding in both obese and non-obese patients with cardiovascular indications. Pharmacotherapy 2017;37(4):393-400. (PMID:28107569
  11. Holbrook A, Schulman S, Witt DM, et al. Evidencebased management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College