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Journals / Türk Biyokimya Dergisi / 2013 / Cilt: 38 - Sayı: 1

The relationship of antioxidants with aging

Yaşlanma ile antioksidanların ilişkisi

Mehmet TARAKÇIOĞLU
İclal GEYİKLİ
Müslüm AKAN
Pages
18–24
Publication Date
2022-11-05
DOI
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The measurements were performed as follows: MDA by using thiobarbituric acid method, TAS, PON and arylesterase with spectrophotometric methods, and coenzyme Q10 with HPLC method were measured.Results: A correlation was found between age and coenzyme Q10 in our study (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, it was aimed to investigate the changing levels of antioxidants along with aging.
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Key Findings & Data:Malondialdehyde (MDA), total antioxidant (TAS) levels, and paraoxanase (PON) and arylesterase enzyme activities were examined as well as Coenzyme Q10, that has an immense role in production of ATP and, in fact, is a potent antioxidant with a lipophillic structureMethods: Research included 160 men and women whose ages differ from 20 to 70 years old and also live in Gaziantep area.
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Conclusion & Impact:The measurements were performed as follows: MDA by using thiobarbituric acid method, TAS, PON and arylesterase with spectrophotometric methods, and coenzyme Q10 with HPLC method were measured.Results: A correlation was found between age and coenzyme Q10 in our study (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, it was aimed to investigate the changing levels of antioxidants along with aging. Malondialdehyde (MDA), total antioxidant (TAS) levels, and paraoxanase (PON) and arylesterase enzyme activities were examined as well as Coenzyme Q10, that has an immense role in production of ATP and, in fact, is a potent antioxidant with a lipophillic structureMethods: Research included 160 men and women whose ages differ from 20 to 70 years old and also live in Gaziantep area. Research was done by dividing subjects into 3 age groups: 50 people belonged to 20–30, 75 people to 31–50 and 35 people to 51–70 age group. Groups were constituted from people who are non-obese and who do not have any physical complaints. In taken plasma samples coenzyme Q10, MDA and TAS levels, PON and arylesterase enzyme activities were measured. The measurements were performed as follows: MDA by using thiobarbituric acid method, TAS, PON and arylesterase with spectrophotometric methods, and coenzyme Q10 with HPLC method were measured.Results: A correlation was found between age and coenzyme Q10 in our study (p

Özet

Amaç: Bu çalışmada, vücuttaki kimyasal reaksiyonlara enerji sağlanmasında önemli rol oynayan ve aynı zamanda lipofilik yapıda güçlü bir antioksidan olan koenzim Q10, malondialdehit (MDA) ve total antioksidan (TAS) düzeyleri, paraoksanaz (PON) ve arilesteraz enzim aktiviteleri gibi antioksidanların yaşlanma ile birlikte değişimlerini incelemek amaçlanmıştır. Yöntemler: Çalışmaya Gaziantep'te ikamet eden yaşları 20-70 arasında değişen 160 sağlıklı birey dahil edildi. Bireyler; 20-30 yaş grubu 50 kişi, 31-50 yaş grubu 75 kişi ve 51-70 yaş grubu 35 kişi olmak üzere 3 gruba ayrıldı. Gruplar obez olmayan, hiçbir fiziksel yakınması bulunmayan kişiler arasından seçildi. Ayrıca bireylerin sağlıklı olup olmadıklarını araştırmak amacıyla rutin biyokimyasal parametreleri ölçüldü. Alınan kanlardan hazırlanan plazma örneklerinde koenzim Q10, MDA ve TAS düzeyleri, PON ve arilesteraz enzim aktiviteleri ölçüldü. MDA düzeyi tiyobarbitürik asit metodu ile, TAS düzeyi, PON ve arilesteraz enzim aktiviteleri spektrofotometrik yöntemle, koenzim Q10 ise HPLC yöntemi ile ölçüldü. Bulgular: Çalışmamızda, yaş ile koenzim Q10 arasında bir ilişki olduğu tespit edildi (p

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Cite This Article

TARAKÇIOĞLU, M., GEYİKLİ, İ., AKAN, M. (2022). The relationship of antioxidants with aging. Türk Biyokimya Dergisi, Cilt: 38 - Sayı: 1, 18–24. https://ajindex.com/articles/621271

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