Journals / Van Tıp Dergisi / 2000 / Cilt: 7 - Sayı: 3

Diagnostic value of reactive oxygen metabolities (Rom) in malignant and nonmalignant pleural effusions

Malign ve nonmalign plevra sıvılarında serbest oksijen radikallerinin tanısal değeri

Pages
102–105
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings indicate patients with pleural effusions are under high influence of free radicals.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, we have measured reactive oxygen metabolities (ROM) in serum and pleural fluids of 75 hospitalized patients with pleural effusions and 21 healthy individuals choosen as control group.
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Key Findings & Data:The etiology of pleural effusions was malignancy in 25 and nonmalignant diseases in 50 cases.
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Conclusion & Impact:These findings indicate patients with pleural effusions are under high influence of free radicals.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tanı teknik ve işlemleri · Plevra hastalıkları · Plevral efüzyon

Abstract

In this study, we have measured reactive oxygen metabolities (ROM) in serum and pleural fluids of 75 hospitalized patients with pleural effusions and 21 healthy individuals choosen as control group. The etiology of pleural effusions was malignancy in 25 and nonmalignant diseases in 50 cases. The mean serum ROM levels of the malignant, nonmalignant, and control groups were 423±180 IU/L, 531±240 IU/L, and 24±789 IU/L, respectively. The levels of serum ROM in the patient groups were higher than that of control group. But, there was not significantly difference between each patient groups. The mean pleural fluid ROM levels of malignant and nonmalignant effusions were 358±127 IU/L and 497±234 IU/L, respectively. In the malignant cases, ROM level of pleural fluid was not significantly higher than that of other group. These findings indicate patients with pleural effusions are under high influence of free radicals. These points should be considered during treatment. Also, ROM level in pleural fluids seems to have no diagnostic value in malignant pleural effusions.

Özet

Bu çalışmada 75 plörezili olgunun plevra sıvısı ve serumunda reaktif oksijen metabolitleri (ROM) ile kontrol grubu olarak seçilen sağlıklı 21 kişinin serum ROM düzeyleri araştırılarak malign-nonmalign plevra sıvılarında tanısal değeri araştırıldı. Olgularımızın 25'inde plörezinin malignite kaynaklı olduğu 50'sinde ise malignite dışı hastalıklara bağlı olduğu saptandı. Ortalama serum ROM düzeyi maligniteli grupta 423±180IU/L olup malignite dışı olgularda 531±240 IU/L ve kontrol grubunda 247±89IU/L idi. Buna göre her iki hastalık grubunda ROM değerleri kontrol grubundan anlamlı yüksek olmasına rağmen kendi aralarında istatiksel anlamlılık yoktu. Çalışmamızda elde edilen ortalama plevra sıvısı ROM düzeyi ise maligniteli olgularda 358±127, malignite dışı olgularda 497±234 olup aralarında istatiksel anlamlılık yoktu. Bu bulgular plörezili hastalarda serum ROM düzeylerinin kontrollere göre oldukça artmış olduğunu ve bunun tedavide dikkate alınması gerektiğini, ancak plevra sıvısı ROM düzeylerinin malignite ve malignite dışı sebebli plörezinin ayırıcı tanısında faydalı olamıyacağını göstermektedir.

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Cite This Article

ÖZBAY, B., DÜLGER, H., GENCER, M., UZUN, K., TARAKÇIOĞLU, M. (2000). Diagnostic value of reactive oxygen metabolities (Rom) in malignant and nonmalignant pleural effusions. Van Tıp Dergisi, Cilt: 7 - Sayı: 3, 102–105. https://ajindex.com/articles/334825

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