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Journals / Türk Biyokimya Dergisi / 2016 / Cilt: 41 - Sayı: 6

Metabolik sendromlu obez çocuklarda iskemi modifiye albumin ve koenzim Q10 düzeylerinin incelenmesi

Investigation of ischemia modified albumin and coenzyme Q10 levels in obese children with metabolic syndrome

İhsan ÇETİN
Sabahattin MUHTAROĞLU
Selda KOÇAK ÖZKAN
Didem KETİ BARLAK
Mustafa KENDİRCİ
Pages
443–449
Publication Date
2022-11-06
DOI
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Furthermore, IMA and CoQ10 levels did not significantly differ between obese children with and without MS, while glucose insulinlevelsandHOMAweresignificantlyhigher(p < 0.001) in obese children with MS than obese without MS and controls.Conclusions: Based on the high levels of IMA, low CoQ10 and association with HOMA and lipid profile; we suggest that obese children may have oxidative damage, lipid per-oxidation and cardiometabolic risk.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The aim of this study was to analyze serum ischemia modified albumin (IMA) and plasma CoQ10 levels and to evaluate their correlation with insulin resistance (homeostatic model assessment, HOMA) and lipid profile in obese children with and without metabolic syndrome (MS).Methods: Thirty-one obese with MS, 30 obese without MS and 34 healthy children aged 6-18 years were included in the study.
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Key Findings & Data:Serum IMA was measured by colorimetric method, plasma CoQ10 levels were measured by HPLC.
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Conclusion & Impact:Furthermore, IMA and CoQ10 levels did not significantly differ between obese children with and without MS, while glucose insulinlevelsandHOMAweresignificantlyhigher(p < 0.001) in obese children with MS than obese without MS and controls.Conclusions: Based on the high levels of IMA, low CoQ10 and association with HOMA and lipid profile; we suggest that obese children may have oxidative damage, lipid per-oxidation and cardiometabolic risk.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: The aim of this study was to analyze serum ischemia modified albumin (IMA) and plasma CoQ10 levels and to evaluate their correlation with insulin resistance (homeostatic model assessment, HOMA) and lipid profile in obese children with and without metabolic syndrome (MS).Methods: Thirty-one obese with MS, 30 obese without MS and 34 healthy children aged 6-18 years were included in the study. Serum IMA was measured by colorimetric method, plasma CoQ10 levels were measured by HPLC. Serum glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and insulin were analyzed.Results: IMA levels were found to be significantly higher (p < 0.001) while the CoQ10 levels were significantly lower (p < 0.001) in obese children with and without MS compared to controls. IMA and CoQ10 significantly correlated with each other and metabolic parameters. Furthermore, IMA and CoQ10 levels did not significantly differ between obese children with and without MS, while glucose insulinlevelsandHOMAweresignificantlyhigher(p < 0.001) in obese children with MS than obese without MS and controls.Conclusions: Based on the high levels of IMA, low CoQ10 and association with HOMA and lipid profile; we suggest that obese children may have oxidative damage, lipid per-oxidation and cardiometabolic risk.

Özet

Amaç: Bu çalışmanın amacı; metabolik sendromu (MS) olan ve olmayan obez çocuklarda; serum iskemi modifiye albümin (İMA), plazma koenzim Q10 (CoQ10) düzeylerinin ölçülmesi ve bu parametrelerin insülin direnci (homeostatic model assessment, HOMA) ve lipid profiliyle ilişkisinin değerlendirilmesidir.Yöntem: Yaşları 6 ile 15 arasında olan 31 MS'li obez, 30 metabolik sendromu olmayan obez ve 34 sağlıklı çocuk çalışmaya dahil edildi. Serum İMA kolorimetrik yöntemle, plazma CoQ10 seviyeleri HPLC ile ölçüldü. Serum glukoz, total kolesterol (TC), trigliserid (TG), yüksek dansiteli lipoprotein kolesterol (HDL-C), düşük dansiteli lipoprotein kolesterol (LDL-C) ve insülin düzeyleri analiz edildi.Bulgular: Obez ve MS'li obez çocuklarda, kontrol grubuna göre İMA seviyeleri istatistiksel olarak anlamlı yüksek (p < 0.001), CoQ10 seviyeleri istatistiksel olarak anlamlı düşük (p < 0.001) bulundu. İMA ve CoQ10 birbirleriyle ve metabolik parametrelerle anlamlı korelasyon gösterdi. Ayrıca glukoz, insülin düzeyleri ve HOMA MS'li obez çocuklarda, MS'li olmayan obez ve kontrol grubuna göre anlamlı yüksek (p < 0.001) iken, İMA ve CoQ10 düzeyleri MS'li obez ve MS'li olmayan obez çocuklar arasında farklılık göstermedi.Sonuç: Yüksek İMA, düşük CoQ10 düzeylerine, HOMA ve lipid profiliyle ilişkisine dayanarak; MS'li obez çocukların oksidatif hasar, lipid peroksidasyonu ve kardiyometabolik açıdan risk altında olduğunu söyleyebiliriz

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Cite This Article

ÇETİN, İ., MUHTAROĞLU, S., ÖZKAN, S. K., BARLAK, D. K., KENDİRCİ, M. (2022). Metabolik sendromlu obez çocuklarda iskemi modifiye albumin ve koenzim Q10 düzeylerinin incelenmesi. Türk Biyokimya Dergisi, Cilt: 41 - Sayı: 6, 443–449. https://ajindex.com/articles/621053

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References (14)

  1. Nadeau KJ, Maahs DM, Daniels SR, Eckel RH. Childhood obesity and cardiovascular disease: links and prevention strategies. Nat Rev Cardiol 2011;8:513-25.
  2. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. J Am Med Assoc 2002;288:2709-16.
  3. Liese AD, D'Agostino RB Jr, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, et al. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics2006;118:1510-8.
  4. Beauloye V, Zech F, Tran HP, Clapuyt P, Maes M. Determinants of early atherosclerosis in obese children and adolescents. J Clin Endocrinol Metab2007;92:3025-32.
  5. Bijari B, Taheri F, Chahkandi T, Kazemi T, Namakin K, Zardast M. The relationship between serum lipids and obesity among elementary school in Birjand: a case control study. J Res Health Sci 2015;15:83-7.
  6. Bourdon E, Loreau N, Blache D. Glucose and free radicals impair the antioxidant properties of serum albumin. FASEB J 1999;13:233-44.
  7. Duarte MM, Rocha JB, Moresco RN, Duarte T, Da Cruz IB, Loro VL, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholester- olemia. Clin Biochem 2009;42:666-71. Valle Gottlieb MG, da Cruz IB, Duarte MM, Moresco RN, Wiehe M, Schwanke CH, et al. Associations among metabolic syndrome, ischemia, inflammatory, oxidatives, and lipids bio- markers. J Clin Endocrinol Metab 2010;95:586-91.
  8. Piva SJ, Tatsch E, De Carvalho JA, Bochi GV, Kober H, Duarte T, et al. Assessment of inflammatory and oxidative biomarkers in obesity and their associations with body mass index. Inflamma- tion 2013;36:226-31.
  9. Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analy- sis of the clinical trials. J Hum Hypertens 2007;21:297-306.
  10. Singh U, Devaraj S, Jialal I. Coenzyme Q10 supplementation and heart failure. Nutr Rev 2007;65:286-93.
  11. Miles MV, Morrison JA, Horn PS, Tang PH, Pesce AJ. Coenzyme Q10 changes are associated with metabolic syndrome. Clin Chim Acta 2004;344:173-9.
  12. Crane FL, Hatefi Y, Lester RL, Widmer C. Isolation of aquinone from beef heart mitochondria. Biochim Biophys Acta 1957;25:220-1.
  13. Frei B, Kim MC, Ames BN. Ubiquinol-10 is an effective lipid soluble antioxidant at physiological concentrations. Proc Natl AcadSci USA 1990;87:4879-83.
  14. Ernster L, Dallner G. Biochemical, physiological and medi-