Gilbert Sendromu: Endotel Disfonksiyonu Üzerinde Koruyucu Etkisi

In correlation analy-sis, UCB was negatively correlated with ADMA, PTX-3 and hs-CRP(r = -0.239,p = 0.034;r = -0.280,p = 0.012andr = -0.224, p = 0.047, respectively).Discussion and conclusion: The present study showed for the first time that decreased levels of ADMA, PTX-3 and hs-CRP may prove the protective effects of hyperbilirubine-mia on the endothelial dysfunction.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Gilbert's syndrome (GS), is a benign condition characterized by unconjugated hyperbilirubinemia related to a decreased hepatic glucuronidating activity without symptoms and signs of liver disease or overt hemolysis.

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Key Findings & Data:In the present study, we aimed to assess circulating levels of asymmetric dimethylarginine (ADMA), pentraxin-3 (PTX-3) and high sensitivity C-reactive protein (hs-CRP) between patients with GS and controls and determine the correlation of unconjugated bilirubin (UCB) levels with these molecules as prognostic factors for vascular risk stratification and endothelial dysfunction.Methods: Forty two patients with GS and 37 age and sex matched control subjects were enrolled in this study.

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Conclusion & Impact:In correlation analy-sis, UCB was negatively correlated with ADMA, PTX-3 and hs-CRP(r = -0.239,p = 0.034;r = -0.280,p = 0.012andr = -0.224, p = 0.047, respectively).Discussion and conclusion: The present study showed for the first time that decreased levels of ADMA, PTX-3 and hs-CRP may prove the protective effects of hyperbilirubine-mia on the endothelial dysfunction.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: Gilbert's syndrome (GS), is a benign condition characterized by unconjugated hyperbilirubinemia related to a decreased hepatic glucuronidating activity without symptoms and signs of liver disease or overt hemolysis. In the present study, we aimed to assess circulating levels of asymmetric dimethylarginine (ADMA), pentraxin-3 (PTX-3) and high sensitivity C-reactive protein (hs-CRP) between patients with GS and controls and determine the correlation of unconjugated bilirubin (UCB) levels with these molecules as prognostic factors for vascular risk stratification and endothelial dysfunction.Methods: Forty two patients with GS and 37 age and sex matched control subjects were enrolled in this study. The diagnosis of GS was made by unconjugated hyperbilirubinemia (1 mg/dL or > 17.1 ?mol/L) on at least two occasions with normal values of other liver function tests, normal hepatic imaging, and absence of hemolysisResults: Serum ADMA, PTX-3 and hs-CRP levels were sig-nificantly lower in GS than the healthy controls (p = 0.037, p = 0.025 and p = 0.040, respectively). In correlation analy-sis, UCB was negatively correlated with ADMA, PTX-3 and hs-CRP(r = -0.239,p = 0.034;r = -0.280,p = 0.012andr = -0.224, p = 0.047, respectively).Discussion and conclusion: The present study showed for the first time that decreased levels of ADMA, PTX-3 and hs-CRP may prove the protective effects of hyperbilirubine-mia on the endothelial dysfunction.

Özet

Amaç: Gilbert Sendromu (GS), karaciğer hastalığı veya aşikar hemoliz belirti ve bulguları olmaksızın, azalmış hepatik glukuronidasyon aktivitesi ile ilişkili, indirekt hiperbilirubinemi ile karakterize benign bir durumdur. Bu çalışmada, GS olan hastalar ile kontrol grubundaki hastaların dolaşımdaki asimetrik dimetilarginin (ADMA), pentraksin-3 (PTX-3) ve yüksek duyarlıklı C-reaktif protein (hs-CRP) düzeylerini değerlendirmek ve vasküler risk sınıflandırması ve endotel disfonksiyonu için prognostik faktörler olarak bu moleküller ile indirekt bilirubin (İB) düzeyleri arasındaki korelasyonunu belirlemek amaçlanmıştır.Yöntem ve Gereçler: GS olan 42 hasta ve yaş ve cinsiyet eş değer olan 37 kontrol hastası çalışmaya dahil edilmiştir. GS tanısı, diger karaciğer fonksiyon testlerinin normal değerlerde tespit edildiği, karaciğer görüntülemesinin normal olduğu ve hemoliz yokluğunda gerçekleştirilen en az iki farklı ölçümde indirekt hiperbilirubinemi (1 mg/dL veya > 17.1 ?mol/L) varlığı ile konulmuştur.Bulgular: Serum ADMA, PTX-3 ve hs-CRP düzeyleri GS hastalarında sağlıklı kontrollere göre anlamlı derecede düşük bulunmuştur (sırasıyla; p = 0.037; p = 0.025 ve p = 0.040). Korelasyon analizinde, İB'nin ADMA, PTX-3 ve hs-CRP ile negatif yönde korele olduğu tespit edilmiştir (sırasıyla; r = -0.239, p = 0.034; r = -0.280, p = 0.012 ve r = -0.224, p = 0.047).Tartışma ve Sonuç: Bu çalışmada ilk kez ADMA, PTX-3 ve hs-CRP düzeylerindeki azalma ile hiperbilirubineminin endotel disfonksiyonu üzerine olan koruyucu etkileri ortaya konulmuştur.

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Cite This Article

SERTOĞLU, E., BİLGİ, C., DOĞAN, T., DOĞRU, T., İNCE, S., TAPAN, S., ACAR, R. (2022). Gilbert Sendromu: Endotel Disfonksiyonu Üzerinde Koruyucu Etkisi. Türk Biyokimya Dergisi, Cilt: 41 - Sayı: 6, 451–458. https://ajindex.com/articles/621036

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