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Journals / Türk Biyokimya Dergisi / 2021 / Cilt: 46 - Sayı: 3

The cytotoxic and apoptotic effects of Ferulago W. Koch extracts on various cancer cell lines

Ferulago W. Koch Türlerinin Çeşitli Kanser Hücre Hatlarında Sitotoksik ve Apoptotik Etkinlikleri

Tuğba GÜNBATAN
Filiz BAKAR ATEŞ
Ceyda Sibel KILIÇ
İlhan GÜRBÜZ
Berna HOTİ
Hayri DUMAN
Pages
281–291
Publication Date
2022-11-06
DOI
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Results: All examined species except F. setifolia inhibited cell viability in PC3 and SW480 cells at 0.01 mg/mL and higher concentrations (p

📌 3 Key Takeaways

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Objective & Hypothesis:Background: The studies investigating the anticancer activities of natural products have accelerated to produce new solutions in the face of increasing cancer cases.
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Key Findings & Data:Material and methods: HPLC analyses were performed by HP Agilent 1,100.
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Conclusion & Impact:Results: All examined species except F. setifolia inhibited cell viability in PC3 and SW480 cells at 0.01 mg/mL and higher concentrations (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: The studies investigating the anticancer activities of natural products have accelerated to produce new solutions in the face of increasing cancer cases. Various Ferulago species are reported to exhibit antioxi dant, antiulcer and antimicrobial activities. Objective: This study aimed to evaluate the cytotoxic and apoptotic activities of ethanolic extracts of roots of five Ferulago species on various human cancer cell lines. Material and methods: HPLC analyses were performed by HP Agilent 1,100. The cytotoxicity were determined by MTT assay. The cell cycle arrest and Annexin V binding analyses were performed by Muse Cell Analyzer (Millipore). Results: All examined species except F. setifolia inhibited cell viability in PC3 and SW480 cells at 0.01 mg/mL and higher concentrations (p

Özet

Amaç: Doğal ürünlerin antikanser aktivitelerini araştıran çalışmalar, artan kanser vakaları karşısında yeni çözümler üretmek için giderek hız kazanmıştır. Çeşitli Ferulago tür lerinin antioksidan, antiülser ve antimikrobiyal aktiviteler sergilediği bildirilmiştir. Bu çalışmada, beş Ferulago türünün köklerinin etanolik ekstraktlarının çeşitli insan kanser hücre hatları üzerindeki sitotoksik ve apoptotik aktivitelerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: HPLC analizleri, HP Agilent 1,100 ile yapıldı. Sitotoksisite, MTT testi ile belirlendi. Hücre döngüsü tutulumu ve Annexin V bağlanma analizleri, Muse Cell Analyzer (Millipore) ile gerçekleştirildi. Bulgular: Elde edilen bulgulara göre, F. setifolia dışında incelenen tüm türler, PC3 ve SW480 hücrelerinde 0,01 mg/mL ve daha yüksek konsantrasyonlarda hücre canlılığını inhibe etmiştir (p

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Cite This Article

GÜNBATAN, T., ATEŞ, F. B., KILIÇ, C. S., GÜRBÜZ, İ., HOTİ, B., DUMAN, H. (2022). The cytotoxic and apoptotic effects of Ferulago W. Koch extracts on various cancer cell lines. Türk Biyokimya Dergisi, Cilt: 46 - Sayı: 3, 281–291. https://ajindex.com/articles/620695

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